GlpBio

HDAC

HDAC(组蛋白去乙酰化酶)

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

HDAC 相关产品(200)

  • GC12074 structure
    GC12074BG45
    CAS: 926259-99-6
    纯度: >99.50%

    A selective HDAC3 inhibitor

  • GC12115 structure
    GC12115CUDC-907
    CAS: 1339928-25-4
    纯度: >99.50%

    CUDC 是一种口服生物可利用的小分子 PI3K 和 HDAC 双重抑制剂，作用于 PI3K α 和 HDAC1 / 2 / 3 / 10，IC50 分别为 19 nm 和 1.7 nm / 5 nm / 1.8 nm / 2.8 nm .在 WSU DLCL2 细胞中评估了双功能 HDAC 和 PI3K 抑制剂 CUDC-907 的抗肿瘤活性。

  • GC12484 structure
    GC12484BRD73954
    CAS: 1440209-96-0
    纯度: >98.00%

    A dual inhibitor of HDAC6 and HDAC8

  • GC12822 structure
    GC12822BML-210(CAY10433)
    CAS: 537034-17-6

    A potent, synthetic HDAC inhibitor

  • GC12971 structure
    GC12971CAY10603
    CAS: 1045792-66-2
    纯度: >99.50%

    An exceptionally potent inhibitor of HDAC6

  • GC12976 structure
    GC12976Suberohydroxamic Acid
    CAS: 38937-66-5

    HDAC inhibitor

  • GC13088 structure
    GC13088BRD6688
    CAS: 1404562-17-9

    A kinetically selective HDAC2 inhibitor

  • GC13435 structure
    GC13435KD 5170
    CAS: 940943-37-3

    An inhibitor of class I and II HDACs

  • GC13706 structure
    GC13706Droxinostat
    CAS: 99873-43-5
    纯度: >99.50%

    An inhibitor of HDAC3, HDAC6, and HDAC8

  • GC14016 structure
    GC14016Sulforaphane
    CAS: 4478-93-7
    纯度: >98.00% / >99.00% / >97.00%

    萝卜硫素 (SFN) 称为 [1-isothiocyanato-4-(methylsulfinyl)butane]。

  • GC14285 structure
    GC14285RGFP966
    CAS: 1357389-11-7
    纯度: >99.50% / >98.00%

    RGFP966是一种N-(o-aminophenyl)carboxamide HDAC抑制剂，对HDAC3的IC50为0.08 μM，是一类针对HDAC3的慢开/慢关竞争性紧密结合抑制剂。

  • GC14367 structure
    GC14367UF 010
    CAS: 537672-41-6
    纯度: >99.50%

    A class I HDAC inhibitor

  • GC14439 structure
    GC14439Santacruzamate A (CAY10683)
    CAS: 1477949-42-0
    纯度: >99.00%

    Santacruzamate A (CAY10683)是一种天然氨基甲酸酯衍生物，可抑制HDAC2和HDAC6活性，IC 50 值分别为0.119nM和434nM。

  • GC14597 structure
    GC14597ITSA-1 (ITSA1)
    CAS: 200626-61-5
    纯度: >98.00%

    ITSA-1 (ITSA1)是一种组蛋白去乙酰化酶（HDAC）激活剂，可以防止动脉层流剪切力诱导的内皮细胞脱落，并降低血管内皮细胞（vECs）中VCAM-1的表达。

  • GC14998 structure
    GC14998Rocilinostat (ACY-1215)
    CAS: 1316214-52-4
    纯度: >98.00%

    A selective inhibitor of HDAC6

  • GC15410 structure
    GC15410Bufexamac
    CAS: 2438-72-4
    纯度: >98.00%

    An NSAID and a class IIb HDAC inhibitor

  • GC15857 structure
    GC15857Sodium butyrate
    CAS: 156-54-7
    纯度: >99.00%

    A short-chain fatty acid and HDAC inhibitor

  • GC17005 structure
    GC170054-iodo-SAHA
    CAS: 1219807-87-0

    A potent SAHA analog

  • GC17472 structure
    GC17472Oxamflatin
    CAS: 151720-43-3
    纯度: >98.00%

    Inhibitor of histone deacetylases

  • GC17703 structure
    GC17703TMP269
    CAS: 1314890-29-3
    纯度: >98.00%

    A selective class IIa HDAC inhibitor

  • GC18206 structure
    GC18206WT161
    CAS: 1206731-57-8
    纯度: >98.50%

    A potent inhibitor of HDAC6

  • GC18402 structure
    GC18402GSK3117391
    CAS: 1018673-42-1
    纯度: >98.50%

    An HDAC inhibitor

  • GC18915 structure
    GC18915Trapoxin A
    CAS: 133155-89-2

    Trapoxin A is a cyclotetrapeptide histone deacetylase (HDAC) inhibitor.

  • GC19020 structure
    GC19020ACY-738
    CAS: 1375465-91-0
    纯度: >98.50%

    ACY-738是一种具有口服活性的选择性组蛋白去乙酰化酶6（HDAC6；IC 50 =1.7nM）抑制剂。