GlpBio

Sirtuin

Sirtuin(Sirtuin蛋白)

Silent information regulator 2 (Sir2) proteins, also known as sirtuins, are a family of nicotine adenine dinucleotide (NAD) dependent protein deacetylases in organisms ranging from bacteria to humans that are characterized by the presence of a unique and highly conserved catalytic domain of approximately 260 amino acids. Sirtuins are divided into 5 classes, including Class I (subclasses Ia, Ib and Ic), Class II, Class III, Class IV (subclasses IVa and IVb) and Class U (Gram-positive bacteria specific). The catalytic domain of sirtuins is comprised of two bilobed globular domains, the large domain containing the NAD-binding pocket and the small domain binding the acetyl-lysine substrate.

Sirtuin 相关产品(74)

  • GC10635 structure
    GC10635EX 527 (SEN0014196)
    CAS: 49843-98-3
    纯度: >98.00%

    EX 527 (SEN0014196) 作为 SIRT1 选择性抑制剂，抑制 Sirt1 的效力比 Sirt2 和 Sirt3 高 100 倍，并且对 Sirt5 的去乙酰化活性没有影响。

  • GC14165 structure
    GC14165Tenovin-1
    CAS: 380315-80-0
    纯度: >99.50%

    A small molecule activator of p53

  • GC14553 structure
    GC14553Resveratrol
    CAS: 501-36-0
    纯度: >99.50%

    白藜芦醇（转-白藜芦醇；SRT501）是一种植物抗菌素。

  • GC14817 structure
    GC14817Salermide
    CAS: 1105698-15-4
    纯度: >98.00%

    A sirtuin inhibitor

  • GC15109 structure
    GC15109SRT2104 (GSK2245840)
    CAS: 1093403-33-8
    纯度: >99.50% / >98.00%

    SRT2104 (GSK2245840) 是 Sirtuin 1 (SIRT1) 的高选择性小分子激活剂，可穿透血脑屏障，减轻脑萎缩，改善运动功能，并防止糖尿病引起的主动脉内皮功能障碍 .用 SRT2104（3µ；M，48 小时）处理可降低 HG 处理的内皮细胞 (EC) 中的 P53 和 Ac-P53 蛋白水平，但不会降低 P53 mRNA 。

  • GC17101 structure
    GC17101SRT1720 HCl
    CAS: 1001645-58-4
    纯度: >99.5% / >98.00%

    SRT1720 HCl 是 SIRT1 的激活剂（EC1.5 = 0.16 µ；M 和最大激活 = 781%），一种 NAD+- 依赖性蛋白和组蛋白脱乙酰酶，在许多生物过程。

  • GC17881 structure
    GC17881AGK 2
    CAS: 304896-28-4
    纯度: >99.50%

    AGK2是一种选择性的SIRT2 抑制剂,IC50为3.5 µM。

  • GC10555 structure
    GC10555Splitomicin
    CAS: 5690-03-9
    纯度: >98.00%

    Inhibitor of yeast Sir2p

  • GC11716 structure
    GC11716SIRT1/2 Inhibitor IV
    CAS: 14513-15-6
    纯度: >99.00%

    Cell-permeable inhibitor of SIRT1 and SIRT2

  • GC12337 structure
    GC12337Tenovin-3
    CAS: 1011301-27-1
    纯度: >99.50%

    A small molecule activator of p53

  • GC13062 structure
    GC13062JGB1741
    CAS: 1256375-38-8

    A SIRT1 inhibitor

  • GC13417 structure
    GC13417EX-527 S-enantiomer
    CAS: 848193-68-0
    纯度: >98.50%

    EX-527 S-对映异构体 ((S)-EX-527) 是一种有效的选择性 SIRT1 抑制剂，IC50 为 98 nM。

  • GC13942 structure
    GC13942SirReal2
    CAS: 709002-46-0
    纯度: >99.00%

    A selective SIRT2 inhibitor

  • GC14686 structure
    GC14686JFD00244
    CAS: 96969-83-4
    纯度: >98.00%

    An inhibitor of SIRT2

  • GC14755 structure
    GC14755Inauhzin
    CAS: 309271-94-1
    纯度: >99.00%

    A selective SIRT1 inhibitor

  • GC15931 structure
    GC15931AGK7
    CAS: 304896-21-7

    An inactive control for AGK2

  • GC16436 structure
    GC16436Tenovin-6
    CAS: 1011557-82-6
    纯度: >98.50%

    A small molecule activator of p53

  • GC17126 structure
    GC17126EX-527 R-enantiomer
    CAS: 848193-69-1
    纯度: >98.50%

    EX-527 R-对映异构体 ((R)-EX-527) 是 Selisstat 的 R-对映异构体。 Selisistat (EX-527) 是一种有效的选择性 SIRT1 抑制剂，IC50 为 98 nM。

  • GC17704 structure
    GC17704Triacetyl Resveratrol
    CAS: 42206-94-0
    纯度: >98.00%

    A resveratrol derivative with diverse biological activities

  • GC17724 structure
    GC17724Thiomyristoyl
    CAS: 1429749-41-6
    纯度: >98.50%

    Thiomyristoyl是一种高效且特异性的SIRT2抑制剂（IC 50 = 28 nM）。

  • GC17922 structure
    GC179224'-bromo-Resveratrol
    CAS: 1224713-90-9

    A potent inhibitor of SIRT1 and SIRT3

  • GC18228 structure
    GC18228CAY10602
    CAS: 374922-43-7
    纯度: >98.50%

    A SIRT1 activator

  • GC19013 structure
    GC190133-TYP
    CAS: 120241-79-4
    纯度: >99.50% / >98.00%

    3-TYP 抑制 SIRT3，IC50 为 16 nM，比 SIRT1 和 SIRT2 更有效，IC50 分别为 88 nM 和 92 nM。

  • GC30204 structure
    GC30204Sirtuin modulator 1
    CAS: 2070015-26-6
    纯度: >99.50%

    A SIRT1 activator