GlpBio

Histone Acetyltransferases

Histone Acetyltransferases(组蛋白乙酰转移酶)

Histone acetyltransferases (HATs) are a diverse group of enzymes catalyzing a posttranslational modification of acetylation in which the acetyl group from the acetyl-CoA cofactor is transferred to the Nζ nitrogen of the target lysine side chain within histones. Based on the sequence divergence within the HAT domain, HATs is classified into at least five distinct families, including HAT1 family, Gcn5/PCAF family, MYST family, p300/CBP family and Rtt109 family. Despite the sequence divergence, a structurally conserved core region has been identified within each of the protein families, which contains a three-stranded β-sheet with a α—helix corresponding to the A and D regions of the Gcn5-related N-acetyltransferases (GNAT) proteins.

Histone Acetyltransferases 相关产品(77)

  • GC12733 structure
    GC12733C646
    CAS: 328968-36-1
    纯度: >98.00%

    C646是一种有效的选择性p300/CBP组蛋白乙酰转移酶抑制剂(Ki 400 nM),已被证明具有多效性,包括神经保护、抗癌和抗上皮间质转化(anti-EMT)作用。

  • GC18153 structure
    GC18153WM-8014
    CAS: 2055397-18-5
    纯度: >99.50%

    An inhibitor of KAT6A and KAT6B

  • GC18154 structure
    GC18154WM-1119
    CAS: 2055397-28-7
    纯度: >99.50%

    WM-1119是一种强效KAT6抑制剂，IC 50 值为6.3μM，对KAT6A、KAT5和KAT7的K D 值分别为0.002μM、2.2μM和0.5μM。

  • GC10174 structure
    GC10174SGC-CBP30
    CAS: 1613695-14-9
    纯度: >99.50%

    A potent inhibitor of CREBBP/EP300 bromodomains

  • GC10226 structure
    GC10226Butyrolactone 3
    CAS: 778649-18-6
    纯度: >95.00% / >98.00%

    Butyrolactone 3是组蛋白乙酰转移酶GCN5的小分子抑制剂（IC 50 = 100μM）。

  • GC10382 structure
    GC10382CPI-637
    CAS: 1884712-47-3
    纯度: >99.50%

    An inhibitor of CBP/EP300 bromodomains

  • GC10931 structure
    GC10931VULM 1457
    CAS: 228544-65-8

    VULM 1457 是一种有效的胆固醇酰基转移酶 (acyl-CoA) 抑制剂。

  • GC11430 structure
    GC11430Remodelin
    CAS: 1622921-15-6
    纯度: >98.00%

    Remodelin 是 N-乙酰转移酶 10 (NAT10) 的小分子抑制剂。

  • GC11439 structure
    GC11439MG 149
    CAS: 1243583-85-8
    纯度: >99.50% / >98.00%

    MG 149是一种组蛋白乙酰转移酶（HAT）抑制剂，对Tip60和MOF的IC 50 值分别为74μM和47μM。

  • GC11539 structure
    GC11539CI 976
    CAS: 114289-47-3

    An inhibitor of ACAT-1

  • GC11972 structure
    GC11972NU 9056
    CAS: 1450644-28-6
    纯度: >98.00%

    NU 9056（1，2-双（异噻唑-5-基）二硫烷）是一种有效且选择性的Tip60（KAT5） 组蛋白乙酰转移酶（HAT）抑制剂，IC 50 值为2μM，具有抗肿瘤活性。

  • GC12009 structure
    GC12009HAT Inhibitor II
    CAS: 932749-62-7
    纯度: >99.00%

    An inhibitor of HAT p300

  • GC12917 structure
    GC12917Acetaminophen
    CAS: 103-90-2
    纯度: >99.00%

    An analgesic and antipyretic compound

  • GC12934 structure
    GC12934YM 750
    CAS: 138046-43-2
    纯度: >98.00%

    YM 750 是一种有效的 acyl-CoA:cholesterol acyltransferase (ACAT) 抑制剂 (IC50\u003d0.18 μM)。

  • GC13474 structure
    GC13474Garcinol
    CAS: 78824-30-3
    纯度: >95.00%

    Garcinol是组蛋白乙酰转移酶p300和PCAF的非特异性抑制剂，IC 50 分别为7μM和5μM。

  • GC14103 structure
    GC14103NSC228155
    CAS: 113104-25-9
    纯度: >98.00%

    An EGFR activator and inhibitor of KID-KIX interactions

  • GC14428 structure
    GC14428CPTH2 (hydrochloride)
    CAS: 2108899-91-6

    A HAT inhibitor

  • GC14524 structure
    GC14524CTPB
    CAS: 586976-24-1
    纯度: >98.00%

    A selective activator of p300 HAT

  • GC14787 structure
    GC14787Curcumin
    CAS: 458-37-7
    纯度: >98.00%

    A yellow pigment with diverse biological activities

  • GC15049 structure
    GC15049MCB-613
    CAS: 1162656-22-5
    纯度: >99.50%

    A small molecule stimulator of SRCs

  • GC15104 structure
    GC15104(R)-(+)-Etomoxir sodium salt
    CAS: 828934-41-4
    纯度: >99.00%

    (R)-(+)-Etomoxir sodium salt(Etomoxir; ETO)是一种用于代谢和心血管疾病的小分子,经酶转化为活性抑制剂乙托莫西里尔辅酶a (IC50 约为0.01-0.70 µM)后,对CPT-1a和CPT-1b的抑制表现出纳摩尔效价。

  • GC15731 structure
    GC15731L002
    CAS: 321695-57-2
    纯度: >98.50%

    A p300 acetyltransferase inhibitor

  • GC15836 structure
    GC15836IWP 12
    CAS: 688353-45-9

    A PORCN inhibitor

  • GC17284 structure
    GC17284Anacardic acid
    CAS: 16611-84-0
    纯度: >98.00%

    A histone acetyltransferase inhibitor