Histone Demethylases

Histone Demethylases(组蛋白去甲基化酶)

Histone demethylases are a diverse group of enzymes catalyzing a process to reverse histone methylation, in which methyl (CH3-) groups are removed from instead of being transferred to histone. So far, two evolutionarily conserved histone demethylase families have been identified, including LSD demethylases and JMJC demethylases. LSD1 and LSD2 are two well-established members of LSD demethylase family, which catalyze demethylation through a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction. LSD1 has been found to demethylate H3K4mel, H3K4me2, H3K9me1, H3K9me2 and a few non-histone targets; while LSD2 has been found to demethylate only H3K4me1 and H3K4me2. Members of JMJC demethylase family is characterized by containing the catalytic JMJC domain, which demethylate substrates, including H3K4, H3K9, H3K27, H3K36 and H4K20, through a Fe(II)- and α-ketogutarate-dependent dioxygenase reaction.

Histone Demethylases 相关产品(103)

GC12961 Apicidin
CAS: 183506-66-3
纯度: >98.00% / >90.00%
A cell-permeable HDAC inhibitor
GC15497 GSK J4 HCl
CAS: 1797983-09-5
纯度: >98.00%
GSK-J4 HCl 是一种小分子抑制剂，具有高效的细胞渗透性和药理学选择性抑制剂，可通过抑制 KDM6B 来保持 H3K27 甲基化。
GC18159 BAY-598
CAS: 1906919-67-2
纯度: >99.50%
BAY-598是一种氨基吡唑啉基的选择性小分子抑制剂，靶点为含有SET和MYND结构域的蛋白2（SMYD2），半抑制浓度（IC 50 ）为27nM。
GC10148 RN 1 dihydrochloride
CAS: 1781835-13-9
纯度: >98.00%
An irreversible LSD1 inhibitor
GC10319 TC-E 5002
CAS: 1453071-47-0
纯度: >98.00%
A KDM2/7 inhibitor
GC10774 CPI-455
CAS: 1628208-23-0
纯度: >98.50% / >98.00%
CPI-455是一种KDM5抑制剂，KDM5（Kissinger Demethylase 5）是一种赖氨酸特异性脱甲基酶，在染色质修饰中起着至关重要的作用，并参与各种生物学过程，包括肿瘤发展和免疫反应。
GC11578 GSK2879552
CAS: 1401966-69-5
纯度: >99.50%
An LSD1 inhibitor
GC11792 OG-L002 HCl
CAS: 1357298-75-9
An LSD1 inhibitor
GC11873 2,4-Pyridinedicarboxylic Acid
CAS: 499-80-9
纯度: >99.00%
An inhibitor of 2-oxoglutarate-dependent enzymes
GC12288 GSK-J1 sodium salt
CAS: 1797832-71-3
A dual inhibitor of JMJD3 and UTX
GC12458 N-Oxalylglycine
CAS: 5262-39-5
An inhibitor of JMJD2 histone demethylases
GC12557 ML324
CAS: 1222800-79-4
纯度: >98.50%
A cell-permeable inhibitor of JMJD2 demethylases
GC12997 GSK J4 free base
CAS: 1373423-53-0
纯度: >99.50% / >98.00%
GSK J4 free base 是 H3K27me3/me2-去甲基化酶 JMJD3/KDM6B 和 UTX/KDM6A 的有效双重抑制剂，IC50 分别为 8.6 和 6.6 μM。 GSK J4 游离碱抑制 LPS 诱导的 TNF-α；在人原代巨噬细胞中产生，IC50 为 9 μM. GSK J4 是 GSK-J1 的细胞渗透性前药。 GSK J4 free base 诱导内质网应激相关的细胞凋亡。
GC13086 GSK J2
CAS: 1394854-52-4
纯度: >99.50%
A negative control compound for GSK-J1
GC13534 Lysine-specific Demethylase Inhibitor (1C)
CAS: 927019-63-4
lysine-specific demethylase Inhibitor
GC13919 Tranylcypromine hydrochloride
CAS: 1986-47-6
An irreversible, mechanism-based inhibitor of LSD1
GC14066 Procaine
CAS: 59-46-1
纯度: >99.00%
An Analytical Reference Standard
GC14631 SP2509
CAS: 1423715-09-6
纯度: >99.50%
A reversible inhibitor of LSD1
GC15301 PBIT
CAS: 2514-30-9
纯度: >98.00% / >99.50%
An inhibitor of JARID1 family demethylases
GC15368 GSK-LSD1 2HCl
CAS: 1431368-48-7
不可逆的、选择性的 LSD1 抑制剂
GC15603 JIB-04
CAS: 199596-05-9
纯度: >98.00%
JIB-04是一种泛选择性Jumonji组蛋白去甲基化酶抑制剂，对JARID1A、JMJD2E、JMJD3、JMJD2A、JMJD2B、JMJD2C和JMJD2D的IC 50 值分别为230nM、340nM、855nM、445nM、435nM、1100nM和290nM。
GC15830 Daminozide
CAS: 1596-84-5
纯度: >98.00%
Selective inhibitor of KDM2/7 histone demethylases
GC16114 Bizine
CAS: 1591932-50-1
纯度: >95.00%
An LSD1 inhibitor
GC17118 GSK J5
CAS: 1394854-51-3
纯度: >95.00%
A negative control compound for GSK-J4

分类产品列表
货号	产品名称	CAS号	纯度
GC12961	Apicidin	183506-66-3	>98.00% / >90.00%
GC12961	A cell-permeable HDAC inhibitor
GC15497	GSK J4 HCl	1797983-09-5	>98.00%
GC15497	GSK-J4 HCl 是一种小分子抑制剂，具有高效的细胞渗透性和药理学选择性抑制剂，可通过抑制 KDM6B 来保持 H3K27 甲基化。
GC18159	BAY-598	1906919-67-2	>99.50%
GC18159	BAY-598是一种氨基吡唑啉基的选择性小分子抑制剂，靶点为含有SET和MYND结构域的蛋白2（SMYD2），半抑制浓度（IC 50 ）为27nM。
GC10148	RN 1 dihydrochloride	1781835-13-9	>98.00%
GC10148	An irreversible LSD1 inhibitor
GC10319	TC-E 5002	1453071-47-0	>98.00%
GC10319	A KDM2/7 inhibitor
GC10774	CPI-455	1628208-23-0	>98.50% / >98.00%
GC10774	CPI-455是一种KDM5抑制剂，KDM5（Kissinger Demethylase 5）是一种赖氨酸特异性脱甲基酶，在染色质修饰中起着至关重要的作用，并参与各种生物学过程，包括肿瘤发展和免疫反应。
GC11578	GSK2879552	1401966-69-5	>99.50%
GC11578	An LSD1 inhibitor
GC11792	OG-L002 HCl	1357298-75-9	-
GC11792	An LSD1 inhibitor
GC11873	2,4-Pyridinedicarboxylic Acid	499-80-9	>99.00%
GC11873	An inhibitor of 2-oxoglutarate-dependent enzymes
GC12288	GSK-J1 sodium salt	1797832-71-3	-
GC12288	A dual inhibitor of JMJD3 and UTX
GC12458	N-Oxalylglycine	5262-39-5	-
GC12458	An inhibitor of JMJD2 histone demethylases
GC12557	ML324	1222800-79-4	>98.50%
GC12557	A cell-permeable inhibitor of JMJD2 demethylases
GC12997	GSK J4 free base	1373423-53-0	>99.50% / >98.00%
GC12997	GSK J4 free base 是 H3K27me3/me2-去甲基化酶 JMJD3/KDM6B 和 UTX/KDM6A 的有效双重抑制剂，IC50 分别为 8.6 和 6.6 μM。 GSK J4 游离碱抑制 LPS 诱导的 TNF-α；在人原代巨噬细胞中产生，IC50 为 9 μM. GSK J4 是 GSK-J1 的细胞渗透性前药。 GSK J4 free base 诱导内质网应激相关的细胞凋亡。
GC13086	GSK J2	1394854-52-4	>99.50%
GC13086	A negative control compound for GSK-J1
GC13534	Lysine-specific Demethylase Inhibitor (1C)	927019-63-4	-
GC13534	lysine-specific demethylase Inhibitor
GC13919	Tranylcypromine hydrochloride	1986-47-6	-
GC13919	An irreversible, mechanism-based inhibitor of LSD1
GC14066	Procaine	59-46-1	>99.00%
GC14066	An Analytical Reference Standard
GC14631	SP2509	1423715-09-6	>99.50%
GC14631	A reversible inhibitor of LSD1
GC15301	PBIT	2514-30-9	>98.00% / >99.50%
GC15301	An inhibitor of JARID1 family demethylases
GC15368	GSK-LSD1 2HCl	1431368-48-7	-
GC15368	不可逆的、选择性的 LSD1 抑制剂
GC15603	JIB-04	199596-05-9	>98.00%
GC15603	JIB-04是一种泛选择性Jumonji组蛋白去甲基化酶抑制剂，对JARID1A、JMJD2E、JMJD3、JMJD2A、JMJD2B、JMJD2C和JMJD2D的IC 50 值分别为230nM、340nM、855nM、445nM、435nM、1100nM和290nM。
GC15830	Daminozide	1596-84-5	>98.00%
GC15830	Selective inhibitor of KDM2/7 histone demethylases
GC16114	Bizine	1591932-50-1	>95.00%
GC16114	An LSD1 inhibitor
GC17118	GSK J5	1394854-51-3	>95.00%
GC17118	A negative control compound for GSK-J4