Histone Demethylases

Histone Demethylases(组蛋白去甲基化酶)

Histone demethylases are a diverse group of enzymes catalyzing a process to reverse histone methylation, in which methyl (CH3-) groups are removed from instead of being transferred to histone. So far, two evolutionarily conserved histone demethylase families have been identified, including LSD demethylases and JMJC demethylases. LSD1 and LSD2 are two well-established members of LSD demethylase family, which catalyze demethylation through a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction. LSD1 has been found to demethylate H3K4mel, H3K4me2, H3K9me1, H3K9me2 and a few non-histone targets; while LSD2 has been found to demethylate only H3K4me1 and H3K4me2. Members of JMJC demethylase family is characterized by containing the catalytic JMJC domain, which demethylate substrates, including H3K4, H3K9, H3K27, H3K36 and H4K20, through a Fe(II)- and α-ketogutarate-dependent dioxygenase reaction.

Histone Demethylases 相关产品(103)

GC73859 LSD1-IN-30
CAS: 1289575-45-6
纯度: >99.00%
LSD1-IN-30（化合物3）是赖氨酸特异性脱甲基酶1（LSD1）的强效抑制剂，IC50值为0.291μM。
GC73981 P3FI-63
CAS: 931596-95-1
纯度: >98.00%
P3FI-63是KDM3B抑制剂，IC50值为7 μM。
GC90195 Posaconazole-d5
CAS: 2649530-57-2
纯度: >98.00%
一种用于量化泊沙康唑的内部标准。
GC11576 Tranylcypromine (2-PCPA) HCl
CAS: 4548-34-9
(1S,2R)-Tranylcypromine ((1S,2R)-SKF 385) hydrochloride 是一种有效的抗抑郁剂。
GC17314 OG-L002
CAS: 1357302-64-7
纯度: >99.50%
An LSD1 inhibitor
GC14151 CBB1007
CAS: 1379573-92-8
CBB1007 是一种细胞可渗透的脒基胍化合物，可作为一种有效的、可逆的和底物竞争性 LSD1 选择性抑制剂（hLSD1 的 IC50 = 5.27 μM）。
GC10617 GSK J1
CAS: 1373422-53-7
纯度: >99.50%
A dual inhibitor of JMJD3 and UTX

分类产品列表
货号	产品名称	CAS号	纯度
GC73859	LSD1-IN-30	1289575-45-6	>99.00%
GC73859	LSD1-IN-30（化合物3）是赖氨酸特异性脱甲基酶1（LSD1）的强效抑制剂，IC50值为0.291μM。
GC73981	P3FI-63	931596-95-1	>98.00%
GC73981	P3FI-63是KDM3B抑制剂，IC50值为7 μM。
GC90195	Posaconazole-d5	2649530-57-2	>98.00%
GC90195	一种用于量化泊沙康唑的内部标准。
GC11576	Tranylcypromine (2-PCPA) HCl	4548-34-9	-
GC11576	(1S,2R)-Tranylcypromine ((1S,2R)-SKF 385) hydrochloride 是一种有效的抗抑郁剂。
GC17314	OG-L002	1357302-64-7	>99.50%
GC17314	An LSD1 inhibitor
GC14151	CBB1007	1379573-92-8	-
GC14151	CBB1007 是一种细胞可渗透的脒基胍化合物，可作为一种有效的、可逆的和底物竞争性 LSD1 选择性抑制剂（hLSD1 的 IC50 = 5.27 μM）。
GC10617	GSK J1	1373422-53-7	>99.50%
GC10617	A dual inhibitor of JMJD3 and UTX