GlpBio

Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

研究方向

Chromatin/Epigenetics 相关产品(1617)

  • GC14945 structure
    GC14945Sirtinol
    CAS: 410536-97-9
    纯度: >98.00%

    Inhibitor of sirtuin deacetylases

  • GC15259 structure
    GC15259EPZ004777 HCl
    CAS: 1380316-03-9
    纯度: >98.00%

    EPZ004777 HCl 是一种有效的选择性 DOT1L 抑制剂，IC50 为 0.4 nM。

  • GC16468 structure
    GC16468CYT387 sulfate salt
    CAS: 1056636-06-6
    纯度: >98.00%

    A potent inhibitor of JAK1 and JAK2

  • GC17178 structure
    GC17178TCS PIM-1 1
    CAS: 491871-58-0
    纯度: >98.00%

    A Pim-1 kinase inhibitor

  • GC10617 structure
    GC10617GSK J1
    CAS: 1373422-53-7
    纯度: >99.50%

    A dual inhibitor of JMJD3 and UTX

  • GC15956 structure
    GC15956WHI-P97
    CAS: 211555-05-4
    纯度: >99.00%

    WHI-P97 是一种有效的选择性 JAK-3 抑制剂。

  • GC15965 structure
    GC15965MC1568
    CAS: 852475-26-4

    A selective class IIa HDAC inhibitor

  • GC11525 structure
    GC11525Pyridone 6
    CAS: 457081-03-7
    纯度: >98.50%

    吡啶酮 6 抑制 Jak3，K(I)=5 nM； Pyridone 6 还抑制 Jak 家族成员 Tyk2 和 Jak2，IC(50)=1 nM 和 Jak1，IC(50)=15 nM。

  • GC10479 structure
    GC10479PHA-680632
    CAS: 398493-79-3
    纯度: >99.50%

    An Aurora kinase inhibitor

  • GC13229 structure
    GC13229NVP-BSK805
    CAS: 1092499-93-8

    A potent, selective JAK2 inhibitor

  • GC16124 structure
    GC16124Ruxolitinib phosphate
    CAS: 1092939-17-7
    纯度: >99.50%

    A potent and selective JAK1/JAK2 inhibitor

  • GC16828 structure
    GC16828Tofacitinib (CP-690550,Tasocitinib)
    CAS: 477600-75-2
    纯度: >98.00%

    Tofacitinib (CP-690550,Tasocitinib)是一种Janus激酶（JAK）抑制剂，用于治疗类风湿关节炎、银屑病关节炎、强直性脊柱炎、多关节病程青少年特发性关节炎和溃疡性结肠炎。

  • GC17020 structure
    GC17020S-Ruxolitinib (INCB018424)
    CAS: 941685-37-6
    纯度: >99.50%

    鲁索替尼 S 对映体是鲁索替尼的 S 对映体。鲁索替尼 S 对映异构体是一种 JAK 抑制剂

  • GC14327 structure
    GC14327XL019
    CAS: 945755-56-6
    纯度: >98.00%

    A potent, bioavailable JAK2 inhibitor

  • GC12064 structure
    GC12064SB1317
    CAS: 937270-47-8
    纯度: >99.50%

    A multi-kinase inhibitor

  • GC17055 structure
    GC170551,2,3,4,5,6-Hexabromocyclohexane
    CAS: 1837-91-8

    1,2,3,4,5,6-六溴环己烷（1,2,3,4,5,6-Hexabromocyclohexane）直接抑制JAK2激酶结构域内的口袋，抑制自身磷酸化。

  • GC15391 structure
    GC15391Cercosporamide
    CAS: 131436-22-1

    A potent inhibitor of fungal Pkc1 and mammalian Mnk isoforms

  • GC13347 structure
    GC13347Cucurbitacin I
    CAS: 2222-07-3
    纯度: >98.00%

    Cucurbitacin I是一种选择性的Janus激酶（JAK）/STAT3信号通路抑制剂，在A549细胞中的IC 50 值为500nM。

  • GC14590 structure
    GC14590AR-42 (OSU-HDAC42)
    CAS: 935881-37-1

    HDAC inhibitor,novel and potent

  • GC14671 structure
    GC14671JANEX-1
    CAS: 202475-60-3
    纯度: >98.00%

    A selective JAK3 inhibitor

  • GC12118 structure
    GC12118SD 1008
    CAS: 960201-81-4

    SD 1008 是一种有效的 JAK 抑制剂。 SD 1008 抑制 STAT3、JAK2 和 Src 的酪氨酰磷酸化。 SD 1008 还降低 STAT3 依赖性荧光素酶活性。 SD 1008 通过直接阻断 JAK-STAT3 信号通路增强紫杉醇诱导的卵巢癌细胞凋亡。

  • GC15536 structure
    GC15536NCH 51
    CAS: 848354-66-5
    纯度: >99.50%

    An HDAC inhibitor

  • GC15040 structure
    GC15040NSC 3852
    CAS: 3565-26-2

    A tumor cell differentiating agent

  • GC16584 structure
    GC16584TCS 21311
    CAS: 1260181-14-3
    纯度: >95.00%

    A JAK3 inhibitor