GlpBio

Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

研究方向

Chromatin/Epigenetics 相关产品(1617)

  • GC52363 structure
    GC52363Citrullinated Histone H3 (R2 + R8 + R17) (2-22)-biotin Peptide

    A biotinylated and citrullinated histone H3 peptide

  • GC52364 structure
    GC52364Vimentin (139-159)-biotin Peptide
    纯度: >98.00%

    A biotinylated vimentin peptide

  • GC52367 structure
    GC52367Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide
    纯度: >99.00%

    A biotinylated and citrullinated mutant vimentin peptide

  • GC52368 structure
    GC52368DL-Sulforaphane Glutathione
    CAS: 289711-21-3
    纯度: >98.00%

    A metabolite of sulforaphane

  • GC52370 structure
    GC52370Citrullinated Vimentin (R144) (139-159)-biotin Peptide
    纯度: >98.00%

    A biotinylated and citrullinated vimentin peptide

  • GC52371 structure
    GC52371Vimentin (G146R) (139-159)-biotin Peptide
    纯度: >98.00%

    A biotinylated mutant vimentin peptide

  • GC52479 structure
    GC52479Histone H3 (Citrullinated R26) (21-44)-GGK-biotin Peptide (trifluoroacetate salt)
    纯度: >95.00%

    A biotinylated peptide fragment of histone H3

  • GC60004 structure
    GC60004(rel)-Tranylcypromine D5 hydrochloride
    CAS: 107077-98-5
    纯度: >98.00%

    Tranylcypromine-d5 (SKF 385-d5) hydrochloride 是氘标记的 (rel)-Tranylcypromine hydrochloride。

  • GC60172 structure
    GC60172Gardenia yellow
    CAS: 94238-00-3

    Gardenia yellow是一种常用的天然食用色素，具有良好的水溶性特性。

  • GC60182 structure
    GC60182GSK046
    CAS: 2474876-09-8
    纯度: >98.00%

    A BD2 bromodomain inhibitor

  • GC60184 structure
    GC60184GSK8814
    CAS: 1997369-78-4
    纯度: >98.50%

    GSK8814 是一种高效、选择性的 ATAD2/2B 溴代苯胺化学探针和抑制剂，结合常数pKd=8.1，在 BROMOscan 中的 pKi=8.9。GSK8814 分别以 7.3 和 4.6 的 pIC50 与 ATAD2 和 BRD4 BD1 结合。GSK8814 对 ATAD2 的选择性是 BRD4 BD1 的 500 倍。

  • GC60310 structure
    GC60310Psammaplin A
    CAS: 110659-91-1
    纯度: >96.00%

    PsammaplinA是一种海洋代谢产物，是HDAC和DNA甲基转移酶(DNAmethyltransferases)的有效抑制剂。PsammaplinA是一种高效的选择性HDAC1抑制剂，IC50为0.9nM，对HDAC1的选择性是DAC6的360倍，对HDAC7和HDAC8的效力低1000倍以上。PsammaplinA对革兰氏阳性细菌(Gram-positivebacteria)具有抗菌作用，并抑制DNA合成和DNA促旋酶(DNAgyrase)活性。抗肿瘤活性。

  • GC60579 structure
    GC60579Amodiaquine dihydrochloride
    CAS: 69-44-3
    纯度: >98.00%

    A prodrug form of N-desethyl amodiaquine

  • GC60833 structure
    GC60833FB23
    CAS: 2243736-35-6
    纯度: >99.00%

    FB23 is a potent and selective inhibitor of FTO demethylase with IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity.

  • GC60919 structure
    GC60919Hydroxycitric acid tripotassium hydrate
    CAS: 6100-05-6
    纯度: >98.00%

    Hydroxycitricacidtripotassiumhydrate(Potassiumcitratemonohydrate)是藤黄果的主要活性成分，也是柠檬酸的衍生物。Hydroxycitricacidtripotassiumhydrate可竞争性抑制柠檬酸裂解酶(ATPcitratelyase)，并具有减肥效果。Hydroxycitricacidtripotassiumhydrate有效抑制结石形成并抑制HIF，具有抗氧化，抗炎和抗肿瘤作用。

  • GC60925 structure
    GC60925IACS-9571 hydrochloride
    CAS: 2319611-93-1
    纯度: >99.00%

    IACS-9571(ASIS-P040)hydrochloride是溴结构域蛋白TRIM24和BRPF1的抑制剂，对TRIM24的IC50和Kd值分别为8nM和31nM，对BRPF1的Kd值为14nM。

  • GC61029 structure
    GC61029Marein
    CAS: 535-96-6
    纯度: >99.00%

    A glucoside chalcone with diverse biological activities

  • GC61058 structure
    GC61058Metoprine
    CAS: 7761-45-7
    纯度: >99.00%

    Metoprine(BW197U)是一种有效的组胺N-甲基转移酶(HMT)抑制剂。Metoprine是一种二氨基嘧啶衍生物，可以透过血脑屏障，并通过抑制HMT增加脑组胺水平。Metoprine是一种抗叶酸(antifolate)和抗肿瘤药。

  • GC61142 structure
    GC61142NSC745885
    CAS: 4219-52-7
    纯度: >98.00%

    NSC745885是一种有效的抗肿瘤(anti-tumor)试剂，对多种癌细胞株有选择性毒性，但对正常细胞没有毒性。NSC745885是一种有效的EZH2的下调因子通过蛋白酶体降解途径。NSC745885为晚期膀胱癌和口腔鳞癌的研究提供了可能性。

  • GC61212 structure
    GC61212PROTAC BRD4 Degrader-5
    CAS: 2409538-70-9
    纯度: >99.50%

    PROTACBRD4Degrader-5是一种基于PROTAC的BRD4降解剂，可有效降解HER2阳性和阴性乳腺癌细胞系中的BRD4。

  • GC61279 structure
    GC61279SIRT-IN-3
    CAS: 1211-19-4
    纯度: >99.00%

    SIRT-IN-3是一种有效的SIRT抑制剂，对SIRT1的IC50为17μM。SIRT-IN-3对SIRT1的选择性分别是SIRT-2和SIRT3的4倍和14倍(IC50forSIRT2=74μM;IC50forSIRT3=235μM)。

  • GC61468 structure
    GC61468MR837
    CAS: 1210906-48-1
    纯度: >99.00%

    MR837是一种NSD2-PWWP1的抑制剂。MR837可以与人核受体结合SET结构域蛋白(PWWP结构域)结合。

  • GC61577 structure
    GC61577CBP/p300-IN-1
    CAS: 2443789-32-8
    纯度: >99.50%

    CBP/p300-IN-1是CBP/EP300溴结构域抑制剂。

  • GC61595 structure
    GC61595(+)-JQ-1-aldehyde
    纯度: >98.00%

    (+)-JQ-1-aldehyde是(+)-JQ1的醛形式。(+)-JQ-1-aldehyde可作为合成PROTACs的前体，靶向BET溴结构域.。