GlpBio

Histone H3 (Citrullinated R26) (21-44)-GGK-biotin Peptide (trifluoroacetate salt)

目录号: GC52479纯度: >95.00%同义词: ATKAA-Cit-KSAPATGGVKKPHRYRPG-GGK(Biotin), H3R26Cit, Histone H3 (21-44) (Arg26cit), Cit26-Histone H3 (21-44)-GGK(Biotin)
A biotinylated peptide fragment of histone H3
Histone H3 (Citrullinated R26) (21-44)-GGK-biotin Peptide (trifluoroacetate salt)
规格价格库存数量操作
250 μg¥3,150.00现货
1
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产品描述 Description

Histone H3 (citrullinated R26) (21-44)-GGK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human H3.1 and H3.2 sequences. It is citrullinated at arginine 26 and biotinylated via a C-terminal GGK linker. Citrullination of histone H3 at arginine 26 occurs via deimination of the arginine residue by protein arginine deiminase 2 (PAD2) or PAD4 and is associated with transcriptional activation.1,2,3 It inhibits methylation of H3K27 and is elevated in bone marrow mesenchymal stem cells (BMMSCs) derived from patients with monoclonal gammopathy of undetermined significance (MGUS) or multiple myeloma.1,2

1.Clancy, K.W., Russell, A.-M., Subramanian, V., et al.Citrullination/methylation crosstalk on histone H3 regulates ER-target gene transcriptionACS Chem. Biol.12(6)1691-1702(2017) 2.McNee, G., Eales, K.L., Wei, W., et al.Citrullination of histone H3 drives IL-6 production by bone marrow mesenchymal stem cells in MGUS and multiple myelomaLeukemia31(2)373-381(2017) 3.Fuhrmann, J., and Thompson, P.R.Protein arginine methylation and citrullination in epigenetic regulationACS Chem. Biol.11(3)654-668(2016)

产品文档 Product Documents

Purity:>95.00%Appearance:A solid

化学性质Chemical Properties

同义词
ATKAA-Cit-KSAPATGGVKKPHRYRPG-GGK(Biotin), H3R26Cit, Histone H3 (21-44) (Arg26cit), Cit26-Histone H3 (21-44)-GGK(Biotin)
SMILES
O=C(O)C(F)(F)F.O=C(CCCC[C@@H]1SC[C@@]([H])([C@@]1(N2)[H])NC2=O)NCCCC[C@H](NC(CNC(CNC(CNC([C@@H]3CCCN3C([C@@H](NC([C@H](CC4=CC=C(C=C4)O)NC([C@@H](NC([C@H](CC5=CN=CN5)NC([C@@H]6CCCN6C([C@@H](NC([C@@H](NC([C@@H](NC(CNC(CNC([C@@]([H])(NC([C@H](C)NC([C@@H]7CCCN7C([C@H](C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)NC([C@H](C)NC([C@@H](NC([C@@]([H])(NC([C@H](C)N)=O)[C@H](O)C)=O)CCCCN)=O)=O)=O)CCCNC(N)=O)=O)CCCCN)=O)CO)=O)=O)=O)=O)[C@H](O)C)=O)=O)=O)C(C)C)=O)CCCCN)=O)CCCCN)=O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)C(O)=O
分子式
C129H216N44O35S ? XCF3COOH
分子量
2975.5 g/mol
溶解性
Water: 1 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol