Marein is a glucoside chalcone that has been found in C. tinctoria and has diverse biological activities, including antioxidant, enzyme inhibitory, antidiabetic, and anti-inflammatory properties.1,2,3 It scavenges DPPH radicals (IC50 = 48.35 μM) in a cell-free assay and is an inhibitor of EGFR (IC50 = 19.94 μM).1,2 Marein (50 mg/kg) reduces fasting blood glucose and fasting serum levels of insulin, triglycerides, LDL cholesterol, and total cholesterol in diabetic db/db mice.3 It also reduces serum and renal IL-6 and chemokine (C-C motif) ligand 2 (CCL2) levels, as well as decreases kidney fibrosis, in db/db mice.
1.Wang, W., Chen, W., Yang, Y., et al.New phenolic compounds from Coreopsis tinctoria Nutt. and their antioxidant and angiotensin i-converting enzyme inhibitory activitiesJ. Agric. Food Chem63(1)200-207(2015) 2.Yang, E.B., Guo, Y.J., Zhang, K., et al.Inhibition of epidermal growth factor receptor tyrosine kinase by chalcone derivativesBiochim Biophys Acta.1550(2)144-152(2001) 3.Guo, Y., Ran, Z., Zhang, Y., et al.Marein ameliorates diabetic nephropathy by inhibiting renal sodium glucose transporter 2 and activating the AMPK signaling pathway in db/db mice and high glucose-treated HK-2 cellsBiomed. Pharmacother.131110684(2020)