GlpBio

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

研究方向

Cell Cycle/Checkpoint 相关产品(1379)

  • GC52474 structure
    GC52474Arg-Gly-Asp (trifluoroacetate salt)
    CAS: 120103-89-1
    纯度: >95.00%

    A synthetic peptide corresponding to an integrin cell adhesion sequence

  • GC52484 structure
    GC52484Purified Ganglioside Mixture (bovine) (ammonium salt)
    纯度: >98.00%

    A mixture of purified bovine gangliosides

  • GC52485 structure
    GC52485Ceramide (non-hydroxy) (bovine spinal cord)
    纯度: >98.00%

    A sphingolipid

  • GC52486 structure
    GC52486Ceramide Phosphoethanolamine (bovine)
    纯度: >98.00%

    A sphingolipid

  • GC52489 structure
    GC52489Ceramide (hydroxy) (bovine spinal cord)
    纯度: >98.00%

    A sphingolipid

  • GC52499 structure
    GC52499Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp (trifluoroacetate salt)
    纯度: >95.00%

    A sensitive substrate for neutrophil elastase

  • GC52513 structure
    GC52513Indolimine-214
    纯度: >98.00%

    A genotoxic gut microbiota metabolite

  • GC60120 structure
    GC60120Danicamtiv
    CAS: 1970972-74-7
    纯度: >99.00%

    A cardiac-specific myosin activator

  • GC60143 structure
    GC60143DM3
    CAS: 796073-54-6

    DM3 (Maytansinoid DM3) 是一种带有二硫键或硫醇基的美登素类似物，是一种 tubulin 的抑制剂，还是一种抗体-药物偶联物 (ADCs) 的细胞毒性部分。

  • GC60259 structure
    GC60259MYCMI-6
    CAS: 681282-09-7

    MYCMI-6 (NSC354961) 是一种有效的选择性内源性 MYC:MAX 蛋白相互作用抑制剂。 MYCMI-6 阻断 MYC 驱动的转录。MYCMI-6 选择性结合 MYC bHLHZip 域，Kd 值为 1.6 μM。MYCMI-6 以 MYC 依赖性的方式抑制肿瘤细胞的生长 (IC50<0.5 μM)。MYCMI-6 对正常人细胞无细胞毒性。MYCMI-6 诱导细胞凋亡 (apoptosis)。

  • GC60294 structure
    GC60294Poloppin
    CAS: 683808-78-8

    Poloppin是一种有效的细胞渗透抑制剂，可抑制有丝分裂的polo样激酶(PLK)IC50=26.9μM)，并可通过Polo-box结构域(PBD)阻止蛋白之间的相互作用(Kd=29.5μM)。Poloppin选择性地杀死表达突变KRAS的细胞，增强有丝分裂中的死亡。Poloppin可用作KRAS突变型癌症的研究，可作为单一试剂，或与c-MET抑制剂联合使用。

  • GC60311 structure
    GC60311PTUPB
    CAS: 1287761-01-6
    纯度: >99.50% / >98.00%

    PTUPB是一种新型的COX-2和sEH双抑制剂，IC 50 值分别为 1.26 nM 和 0.9μM。

  • GC60376 structure
    GC60376UC2288
    CAS: 1394011-91-6
    纯度: >99.50%

    UC2288 is a novel, cell-permeable, and orally active p21 attenuator, decreases p21 mRNA expression independently of p53, and attenuates p21 protein levels with minimal effect on p21 protein stability.

  • GC60620 structure
    GC60620Batabulin
    CAS: 195533-53-0
    纯度: >99.50%

    An inhibitor of tubulin polymerization

  • GC60621 structure
    GC60621Batabulin sodium
    CAS: 195533-98-3
    纯度: >99.50%

    An inhibitor of tubulin polymerization

  • GC60628 structure
    GC60628BD750
    CAS: 892686-59-8
    纯度: >99.50%

    BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.5 μM and 1.1 μM for mouse and human T-cell proliferation, respectively.

  • GC60688 structure
    GC60688Cereblon modulator 1
    CAS: 1860875-51-9
    纯度: >99.50%

    A modulator of cereblon

  • GC60871 structure
    GC60871Gemigliptin tartrate
    CAS: 1374639-74-3
    纯度: >98.00%

    A DPP-4 inhibitor

  • GC60891 structure
    GC60891GW406108X
    CAS: 1644443-92-4
    纯度: >98.00%

    GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.

  • GC61014 structure
    GC61014Lusianthridin
    CAS: 87530-30-1

    Lusianthridin是来自Dendrobiumvenustum的天然化合物，具有抗迁移作用。Lusianthridin通过抑制Src-STAT3信号，促进c-Myc的降解。

  • GC61043 structure
    GC61043Mesalamine impurity P
    CAS: 887256-40-8

    MesalamineimpurityP是Mesalamine的杂质。5-Aminosalicylicacid(Mesalamine)是一种特异性的 PPARγ 激动剂，还抑制p21-激活激酶1(PAK1)和 NF-κB。

  • GC61072 structure
    GC61072MK-28
    CAS: 864388-65-8
    纯度: >99.50% / >98.00%

    MK-28是一种有效且选择性的胰腺内质网激酶（PERK）激动剂，通过调节内质网应激反应发挥作用。

  • GC61286 structure
    GC61286SP-8356
    CAS: 1454885-45-0
    纯度: >99.00%

    SP-8356, an anti-inflammatory synthetic verbenone derivative, is a CD147 inhibitor with respect to its regulation of breast cancer cell behavior and cancer progression.

  • GC61314 structure
    GC61314Taltobulin hydrochloride
    纯度: >99.00%

    Taltobulinhydrochloride(HTI-286hydrochloride)是一种合成的三肽半胱氨酸类似物，Taltobulin是一种有效的抗微管剂(antimicrotubule)，可在体内外规避P-糖蛋白介导的耐药性。Taltobulinhydrochloride抑制纯化的微管蛋白聚合，破坏细胞中的微管组织，并诱导有丝分裂停滞以及凋亡(apoptosis)。