GlpBio

GW406108X

目录号: GC60891纯度: >98.00%同义词: GW108X
GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.
GW406108X
Cas No.: 1644443-92-4
规格价格库存数量操作
5mg¥1,620.00现货
1
10mg¥2,610.00现货
1
25mg¥4,950.00现货
1
50mg¥7,920.00现货
1
100mg¥12,600.00现货
1
10mM (in 1mL DMSO)¥1,782.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
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    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.

[1] Megan E Dumas, et al. Bioorg Med Chem Lett. 2019 Jan 15;29(2):148-154. [2] Maria Zachari, et al.Biochem J. 2020 Feb 28;477(4):801-814.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
1644443-92-4
同义词
GW108X
SMILES
O=C1NC2=C(C=C(C(C3=CC=CO3)=O)C=C2)/C1=C/C4=CC(Cl)=C(O)C(Cl)=C4
分子式
C20H11Cl2NO4
分子量
400.21 g/mol
溶解性
DMSO: 62.5 mg/mL (156.17 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol