Cell Cycle/Checkpoint
Cell Cycle/Checkpoint(细胞周期/检查点)
Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more
- ATM/ATR(29)
- Aurora Kinase(58)
- Cdc42(4)
- Cdc7(3)
- Chk(14)
- c-Myc(27)
- CRM1(8)
- Cyclin-Dependent Kinases(77)
- E1 enzyme(1)
- G-quadruplex(12)
- Haspin(6)
- HMTase(1)
- Kinesin(27)
- Ksp(4)
- Microtubule/Tubulin(257)
- Mps1(15)
- Mitotic(7)
- RAD51(13)
- ROCK(74)
- Rho(13)
- PERK(11)
- PLK(43)
- PTEN(6)
- Wee1(9)
- PAK(25)
- Arp2/3 Complex(8)
- Dynamin(14)
- ECM & Adhesion Molecules(54)
- Cytoskeleton & Motor Proteins(65)
- Endomembrane System & Vesicular Trafficking(36)
- G1(51)
- Genotoxic Stress(23)
- G2/M(40)
- G2/S(17)
- Inositol Phosphates(67)
- Proteolysis(183)
- Cellular Chaperones(14)
- Cyclin G-associated Kinase (GAK)(1)
- MARK(3)
- NEKs(1)
Cell Cycle/Checkpoint 相关产品(1379)
- GC61584Vinflunine ditartrateCAS: 194468-36-5纯度: >95.00%
Vinflunineditartrate是一种长春花生物碱家族的氟化微管抑制剂。Vinflunineditartrate具有抗血管生成，破坏血管和抗转移的活性。Vinflunineditartrate可用于尿路上皮移行细胞癌，非小细胞肺癌和乳腺癌的研究。
- GC62108Elimusertib hydrochloride纯度: >99.50%
Elimusertib (BAY 1895344) hydrochloride 是一种有效、可口服、选择性的 ATR 抑制剂，IC50 值为 7 nM，具有抗肿瘤活性。Elimusertib hydrochloride 可用于实体瘤和淋巴瘤的研究。
- GC62128BractoppinCAS: 2290527-07-8纯度: >99.00%
Bractoppin 是一种串联 BRCT（串联 BRCT，BRCA1），由人乳腺癌和卵巢癌抑制蛋白 (BRCA1) tBRCT 结构域识别磷酸肽的药物样抑制剂，在体外选择性抑制底物结合的纳摩尔活性，IC50 为0.074 77777#181;M。
- GC62145ChiauranibCAS: 1256349-48-0纯度: >99.00%
Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.
- GC62189CD532 hydrochloride纯度: >99.00%
An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction
- GC62594hnRNPK-IN-1CAS: 2313528-04-8纯度: >97.00%
hnRNPK-IN-1 是一种异质核糖核蛋白 K (hnRNPK) 结合配体，用 SPR 和 MST 测量的 Kd 值分别为 4.6 μM 和 2.6 μM。hnRNPK-IN-1 通过破坏 hnRNPK 和 c-myc 启动子的结合来抑制 c-myc 转录。hnRNPK-IN-1诱导 Hela 细胞凋亡 (apoptosis)，并具有很强的抗肿瘤活性。
- GC62711BAMEA-O16BCAS: 2490668-30-7纯度: >99.00%
BAMEA-O16B 是一种脂质纳米颗粒。BAMEA-O16B 结合了二硫键，可以有效地将 Cas9 mRNA 和 sgRNA 传递到细胞中，同时响应细胞内还原环境释放 RNA 进行基因组编辑。BAMEA-O16B 可用于基因编辑的研究。
- GC62728(1E)-CFI-400437 dihydrochlorideCAS: 1247000-76-5纯度: >98.50%
CFI-400437 is a potent and selective polo-like kinase 4 (PLK4) inhibitor.
- GC627772-Methoxy-4-vinylphenolCAS: 7786-61-0纯度: >98.00%
2-Methoxy-4-vinylphenol (2M4VP) 是天然的发芽抑制剂，具有抗炎活性。
- GC63165RAD51-IN-1CAS: 2101739-18-6纯度: >99.50%
RAD51-IN-1 是 B02 的衍生物，是 RAD51 的有效抑制剂。 RAD51-IN-1 可用于癌症研究。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC61400 | MAP4343 | 511-26-2 | >98.00% | |
MAP4343是Pregnenolone的3-甲基醚衍生物。MAP4343在体外与微管相关蛋白2(MAP2)结合，刺激微管蛋白的聚合，增强神经突的延伸并保护神经元免受神经毒性剂的侵害。 | ||||
| GC61584 | Vinflunine ditartrate | 194468-36-5 | >95.00% | |
Vinflunineditartrate是一种长春花生物碱家族的氟化微管抑制剂。Vinflunineditartrate具有抗血管生成，破坏血管和抗转移的活性。Vinflunineditartrate可用于尿路上皮移行细胞癌，非小细胞肺癌和乳腺癌的研究。 | ||||
| GC61831 | Benproperine phosphate | 19428-14-9 | >98.00% | |
An antitussive agent and ARPC2 inhibitor | ||||
| GC61870 | NY2267 | 886053-73-2 | >99.00% | |
NY2267 是一种 Myc-Max 相互作用 (Myc-Max interaction) 干扰物，其 IC50 值为 36.5 µM。 | ||||
| GC61995 | PKCβ inhibitor 1 | 257879-35-9 | >98.00% | |
A PKCβ Inhibitor | ||||
| GC62108 | Elimusertib hydrochloride | - | >99.50% | |
Elimusertib (BAY 1895344) hydrochloride 是一种有效、可口服、选择性的 ATR 抑制剂，IC50 值为 7 nM，具有抗肿瘤活性。Elimusertib hydrochloride 可用于实体瘤和淋巴瘤的研究。 | ||||
| GC62128 | Bractoppin | 2290527-07-8 | >99.00% | |
Bractoppin 是一种串联 BRCT（串联 BRCT，BRCA1），由人乳腺癌和卵巢癌抑制蛋白 (BRCA1) tBRCT 结构域识别磷酸肽的药物样抑制剂，在体外选择性抑制底物结合的纳摩尔活性，IC50 为0.074 77777#181;M。 | ||||
| GC62145 | Chiauranib | 1256349-48-0 | >99.00% | |
Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy. | ||||
| GC62174 | ON1231320 | 1312471-39-8 | >98.00% | |
ON1231320 (7ao), an arylsulfonyl pyrido-pyrimidinone, is a highly specific inhibitor of polo like kinase 2 (PLK2). It also blocks tumor cell cycle progression in the G2/M phase in mitosis and causes apoptosis. | ||||
| GC62189 | CD532 hydrochloride | - | >99.00% | |
An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction | ||||
| GC62205 | Maytansine | 35846-53-8 | >99.50% | |
An ansa macrolide with anticancer activity | ||||
| GC62287 | EN4 | 1197824-15-9 | >96.00% | |
EN4, a covalent ligand that targets cysteine 171 (C171) of MYC, is selective for c-MYC over N-MYC and L-MYC. EN4 inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis. | ||||
| GC62383 | (±)-ErSO | 2407860-40-4 | - | |
(±)-ErSO 是 ErSO 的消旋体。ErSO 是选择性预期未折叠蛋白反应 (a-UPR) 激活物。 | ||||
| GC62433 | AKI603 | 1432515-73-5 | >98.00% | |
AKI-603 is an inhibitor of Aurora kinase A (AurA), which is developed to overcome resistance mediated by BCR-ABL-T315I mutation. | ||||
| GC62443 | ErSO | 2407860-35-7 | - | |
ErSO activates the anticipatory unfolded protein response (a-UPR) with an IC50 of 20.3 nM in MCF-7 cells. ErSO induces rapid and selective necrosis of ERα-positive breast cancer cell lines in vitro. | ||||
| GC62449 | WEE1-IN-3 | 2272976-28-8 | >98.00% | |
WEE1-IN-3 是一种有效的 Wee1 激酶抑制剂，其 IC50 <10 nM。WEE1-IN-3 具有抗癌活性。 | ||||
| GC62482 | TAS-119 | 1453099-83-6 | >98.00% | |
TAS-119 是一种有效的，选择性的，具有口服活性的 Aurora A 抑制剂，IC50 为 1.0 nM。TAS-119 对 Aurora A 的选择性高于其他蛋白激酶，包括 Aurora B (IC50 为 95 nM)。TAS-119 具有有效的抗肿瘤活性。 | ||||
| GC62594 | hnRNPK-IN-1 | 2313528-04-8 | >97.00% | |
hnRNPK-IN-1 是一种异质核糖核蛋白 K (hnRNPK) 结合配体，用 SPR 和 MST 测量的 Kd 值分别为 4.6 μM 和 2.6 μM。hnRNPK-IN-1 通过破坏 hnRNPK 和 c-myc 启动子的结合来抑制 c-myc 转录。hnRNPK-IN-1诱导 Hela 细胞凋亡 (apoptosis)，并具有很强的抗肿瘤活性。 | ||||
| GC62657 | MRIA9 | 2750707-05-0 | >98.00% | |
MRIA9 是 ATP 竞争性的、pan-SIK 和 PAK2/3 抑制剂，其对 SIK1、SIK2 和 SIK3 的 IC50 值分别为 516 nM, 180 nM 和 127 nM。 | ||||
| GC62697 | ZN-c3 | 2376146-48-2 | >99.50% | |
ZN-c3 is an oral active, highly effective and selective Wee1 inhibitor with IC50 of 3.9 nM, which can be used in cancer research. | ||||
| GC62711 | BAMEA-O16B | 2490668-30-7 | >99.00% | |
BAMEA-O16B 是一种脂质纳米颗粒。BAMEA-O16B 结合了二硫键，可以有效地将 Cas9 mRNA 和 sgRNA 传递到细胞中，同时响应细胞内还原环境释放 RNA 进行基因组编辑。BAMEA-O16B 可用于基因编辑的研究。 | ||||
| GC62728 | (1E)-CFI-400437 dihydrochloride | 1247000-76-5 | >98.50% | |
CFI-400437 is a potent and selective polo-like kinase 4 (PLK4) inhibitor. | ||||
| GC62777 | 2-Methoxy-4-vinylphenol | 7786-61-0 | >98.00% | |
2-Methoxy-4-vinylphenol (2M4VP) 是天然的发芽抑制剂，具有抗炎活性。 | ||||
| GC63165 | RAD51-IN-1 | 2101739-18-6 | >99.50% | |
RAD51-IN-1 是 B02 的衍生物，是 RAD51 的有效抑制剂。 RAD51-IN-1 可用于癌症研究。 | ||||