ErSO activates the anticipatory unfolded protein response (a-UPR) with an IC50 of 20.3 nM in MCF-7 cells. ErSO induces rapid and selective necrosis of ERα-positive breast cancer cell lines in vitro.
[1] Matthew W Boudreau, et al. Sci Transl Med . 2021 Jul 21;13(603):eabf1383.
















