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Neuroscience

Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

研究方向

Neuroscience 相关产品(3932)

  • GC30680 structure
    GC30680Gastrin/CCK antagonist 1
    CAS: 162271-52-5

    Gastrin/CCKantagonist1是gastrin/CCK的拮抗剂，可用于肠胃失调疾病的研究。

  • GC30681 structure
    GC30681Revexepride
    CAS: 219984-49-3

    Revexepride是一种高度选择性的5-HT4receptor激动剂，也是潜在的CYP3A4enzyme诱导剂，可用于治疗胃食管返流疾病。

  • GC30752 structure
    GC30752CCK-B Receptor Antagonist 1
    CAS: 168161-71-5
    纯度: >99.00%

    CCK-B Receptor Antagonist 1 是胆囊收缩素 B (CCK-B) 受体的拮抗剂，具有减少胃酸分泌的潜力。

  • GC30759 structure
    GC30759H3 receptor-MO-1
    CAS: 1240914-03-7

    H3receptor-MO-1是一种组胺H3受体(histamineH3receptor)调节剂。

  • GC30762 structure
    GC30762Harmine (Telepathine)
    CAS: 442-51-3
    纯度: >99.50%

    A unique regulator of PPARγ expression

  • GC30766 structure
    GC30766Tranylcypromine hemisulfate (dl-Tranylcypromine hemisulfate)
    CAS: 13492-01-8
    纯度: >99.00%

    Tranylcypromine (Parnate) is an irreversible inhibitor of monoamine oxidase (MAO) with a rapid onset of activity.

  • GC30772 structure
    GC30772Dopamine serotonin antagonist-1
    CAS: 1977-07-7

    Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs (muscarinic Designer Receptors Exclusively Activated by Designer Drugs) agonist, and binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively.

  • GC30773 structure
    GC30773Phenelzine sulfate
    CAS: 156-51-4
    纯度: >99.00%

    Phenelzine sulfate是一种单胺氧化酶（MAO）抑制剂。

  • GC30774 structure
    GC30774Tat-NR2B9c
    CAS: 500992-11-0
    纯度: >98.00%

    Tat-NR2B9c 旨在通过阻止突触后密度蛋白 95 (PSD-95) 与 N-甲基-D-天冬氨酸 (NMDA) 受体和神经元一氧化氮结合来阻止一氧化氮 (NO) 的产生氧化物合成酶。

  • GC30775 structure
    GC30775Histamine (Ergamine)
    CAS: 51-45-6
    纯度: >99.00% / >98.00%

    A biogenic amine

  • GC30780 structure
    GC30780Fipexide
    CAS: 34161-24-5
    纯度: >98.00%

    Fipexide (hydrochloride) is a psychoactive drug of the piperazine class.

  • GC30787 structure
    GC30787Sertindole (Lu 23-174)
    CAS: 106516-24-9
    纯度: >99.50%

    An atypical antipsychotic

  • GC30788 structure
    GC30788L-Glutamic acid monosodium salt (Monosodium glutamate)
    CAS: 142-47-2
    纯度: >98.00% / >99.50%

    L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

  • GC30790 structure
    GC30790Triflupromazine hydrochloride
    CAS: 1098-60-8
    纯度: >99.50%

    A phenothiazine with diverse biological activities

  • GC30796 structure
    GC30796Nelotanserin (APD125)
    CAS: 839713-36-9
    纯度: >99.50%

    Nelotanserin (APD125) 是一种有效的 5-HT2A 反向激动剂、中度有效的 5-HT2C 部分反向激动剂和弱 5-HT2B 反向激动剂，在 IP 积累试验中 IC50 分别为 1.7、79、791 nM。

  • GC30797 structure
    GC30797lumateperone Tosylate (ITI-007)
    CAS: 1187020-80-9
    纯度: >99.00%

    An atypical antipsychotic

  • GC30807 structure
    GC30807ZSET1446 (ST-101)
    CAS: 887603-94-3
    纯度: >98.00%

    ZSET1446 (ST-101) 是一种新型认知增强剂，可显着改善各种类型的阿尔茨海默病 (AD) 模型中的学习缺陷。

  • GC30809 structure
    GC30809VU0467154
    CAS: 1451993-15-9
    纯度: >99.50%

    A positive allosteric modulator of the M 4 muscarinic acetylcholine receptor

  • GC30810 structure
    GC30810Donepezil (E2020)
    CAS: 120014-06-4
    纯度: >99.50%

    Donepezil (E2020)是一种乙酰胆碱酯酶（AChE）抑制剂，IC50为6.7nM。

  • GC30812 structure
    GC30812Imidafenacin (KRP-197)
    CAS: 170105-16-5
    纯度: >98.00%

    Imidafenacin (KRP-197, ONO-8025) is a urinary antispasmodic of the anticholinergic class. It is a novel antimuscarinic agent with safety and efficacy, has been clinically used for the treatment of overactive bladder. Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). IC50 value: 0.3 nM(M3).

  • GC30818 structure
    GC30818ZL006
    CAS: 1181226-02-7
    纯度: >98.00%

    An nNOS/PSD-95 interaction inhibitor

  • GC30821 structure
    GC30821JNJ-39758979
    CAS: 1046447-90-8
    纯度: >98.00%

    JNJ-39758979是一个有选择性且具有高亲和性的组胺H4受体拮抗剂,其Ki值为12.5nM。

  • GC30822 structure
    GC30822Solifenacin (YM905)
    CAS: 242478-37-1
    纯度: >98.00%

    Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.

  • GC30823 structure
    GC30823Edonerpic maleate (T-817 maleate)
    CAS: 519187-97-4
    纯度: >98.50%

    T-817MA propyl}-3-azetidinol maleate] 是一种新合成的阿尔茨海默病 (AD) 治疗剂，具有神经保护作用β-淀粉样肽 (Aβ) 的毒性和促进神经突生长的作用.T-817MA 预处理 24 小时后，T-817MA 在 0.1 和 1 uM 时显着防止 H2O2 处理引起的神经元损伤。