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Home >> Signaling Pathways >> Neuroscience

Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for  Neuroscience

  1. Cat.No. 产品名称 Information
  2. GC33677 Iproniazid phosphate

    磷酸异丙烟肼

     Iproniazid (Marsilid, Iprazid) phosphate is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.
  3. GC33674 Methiothepin mesylate (Metitepine mesylate)

    马来酸甲硫替平; Metitepine mesylate; Ro 8-6837 mesylate

     Methiothepin mesylate (Metitepine mesylate) 是一种有效且非选择性的 5-HT2 受体拮抗剂，pKd 值为 7.10 (5-HT1A)、7.28 (5HT1B)、7.56 (5HT1C)、6.99 (5HT1D)、7.0 (5-HT5A) 、7.8 (5-HT5B)、8.74 (5-HT6) 和 8.99 (5-HT7)，以及 8.50 (5HT2A)、8.68 (5HT2B) 和 8.35 (5HT2C) 的 pKis。
  4. GC33673 24-Hydroxycholesterol

    24-羟基胆固醇

    24-Hydroxycholesterol是一种天然的固醇类物质，是n-甲基-d-天门冬氨酸受体(NMDA)和转录因子LXR的激活剂。
  5. GC33668 Naspm (1-Naphthylacetyl spermine)

    1-Naphthylacetyl spermine

     Naspm (1-Naphthylacetyl semimine) (1-Naphthyl acetyl semimine) 是 Joro 蜘蛛毒素的合成类似物，是一种钙渗透性 AMPA (CP-AMPA) 受体拮抗剂。
  6. GC33664 SKF-82958 hydrobromide ((±)-SKF 82958 hydrobromide)

    (±)-SKF-82958 hydrobromide; Chloro-APB hydrobromide

     A dopamine D1 receptor agonist
  7. GC33632 Veratric acid (3,4-Dimethoxybenzoic acid)

    藜芦酸; 3,4-Dimethoxybenzoic acid

     Veratric acid (3,4-Dimethoxybenzoic acid), a simple benzoic acid derived from plants and fruits, has anti-oxidant, anti-inflammation, and blood pressure-lowering effects. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation.
  8. GC33595 β-CGRP, human

    Β-降钙素基因相关肽,人,Human β-CGRP; CGRP-II (Human)

     β-CGRP, human是一种神经肽激素，由降钙素基因相关肽家族产生，可与降钙素受体样受体CRLR和RAMP形成复合物（CRLR/RAMP1：IC50 = 1nM；CRLR/RAMP2：IC50 = 300nM）。
  9. GC33573 Rasagiline 13C3 mesylate racemic (AGN1135 13C3 racemic)

    AGN1135 13C3; TVP1012 13C3 racemic

     Rasagiline 13C3 mesylate racemic (AGN1135 13C3 racemic) 是一种 13C 标记的 Rasagiline mesylate 外消旋体。
  10. GC33559 Netupitant metabolite Monohydroxy Netupitant (Monohydroxy Netupitant)

    奈妥匹坦杂质A,Monohydroxy Netupitant

     Monohydroxy Netupitant 是 Netupitant 的代谢物，Netupitant 是一种高选择性的 NK1 受体拮抗剂。
  11. GC33552 ABT-670

    ABT-670是一种具有选择性，可口服的dopamineD4受体抑制剂。
  12. GC33544 (±)-Methotrimeprazine (D6) (dl-Methotrimeprazine D6)

    (±)-Methotrimeprazine-d6; dl-Methotrimeprazine-d6

     (±)-Levomepromazine D6 ((±)-Methotrimeprazine D6) 是氘标记的 Methotrimeprazine，它是一种 D3 多巴胺和组胺 H1 受体拮抗剂。
  13. GC33527 Trimethobenzamide hydrochloride (Ro 2-9578)

    盐酸三甲氧苯酰胺,Ro 2-9578

     A dopamine D2 receptor antagonist and antiemetic
  14. GC33510 Org-10490 Org-10490是一种dopamineD1受体和dopamineD2受体的拮抗剂，常用于治疗神经疾病。
  15. GC33504 4-Acetamidobutanoic acid (N-acetyl GABA)

    4-乙酰氨基丁酸,N-acetyl GABA

     A GABA derivative
  16. GC33499 Fexofenadine D6 (MDL-16455 D6)

    非索非那定-D6,MDL-16455-d6; Terfenadine carboxylate-d6

     Fexofenadine D6 (MDL-16455 D6) 被氘标记为 Fexofenadine，它是一种抗组胺药。
  17. GC33492 Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate)

    GLYX-13 Trifluoroacetate

     A partial agonist of the NMDA receptor
  18. GC33484 Ampyrone (4-Aminoantipyrine)

    4-氨基安替比林

     4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.
  19. GC33434 Methacholine chloride

    醋甲胆碱; Acetyl-β-methylcholine chloride

     Methacholine chloride是一种有效的毒蕈碱受体激动剂。Methacholine chloride能够直接作用于平滑肌上的乙酰胆碱受体，导致支气管收缩和气道变窄。
  20. GC33344 WAY 163909

    (8AR,11AR)-9H-4,5,6,7,8A,10,11,11A-八氢环戊并[4,5]吡咯并[3,2,1-JK][1,4]苯并二氮杂卓

     WAY163909是有效的且有选择性的5-HT(2C)receptor激动剂,Ki值为10.5±1.1nM。
  21. GC33341 Transcrocetin (trans-Crocetin)

    藏红花酸; trans-Crocetin

     A natural apocarotenoid with diverse biological activities
  22. GC33160 amyloid P-IN-1 amyloidP-IN-1有利于在疾病或功能失调的治疗中消耗血清淀粉样蛋白P组件(SAP)，包括淀粉样变,阿尔茨海默病，2型糖尿病和关节炎。
  23. GC33067 Sophoflavescenol

    槐苦参醇

     Sophoflavescenol是一种异戊烯基黄酮类化合物，能够抑制PDE5的活性，IC50值为0.013μM；同时抑制RLAR，HRAR，BACE1，AChE和BChE，IC50值分别为0.30µM，0.17µM，10.98µM，8.37µM和8.21µM。
  24. GC32979 Chloropyramine hydrochloride

    盐酸氯吡胺

     Chloropyramine hydrochloride (Halopyramine) is a histamine receptor H1 antagonist and has anti-cholinergic, antispasmodic, and antiallergic effects.
  25. GC32957 (-)-Catechin gallate ((-)-Catechin 3-gallate)

    儿茶素没食子酸酯; (-)-Catechin 3-gallate; (-)-Catechin 3-O-gallate

     A polyphenol with diverse biological activities
  26. GC32905 Alprenolol ((RS)-Alprenolol)

    阿普洛尔; (RS)-Alprenolol; dl-Alprenolol

     A non-selective β-AR and 5-HT receptor antagonist
  27. GC32851 Calcitonin salmon (Salmon calcitonin)

    鲑降钙素,Salmon calcitonin

     Calcitonin salmon (Salmon calcitonin)是一种从鲑鱼中提取的降钙素类药物。
  28. GC32841 Catechin ((+)-Catechin)

    儿茶素; (+)-Catechin; Cianidanol; Catechuic acid

     (+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.
  29. GC32776 Pentagastrin (ICI-50123)

    五肽胃泌素; ICI-50123

     A CCK2 receptor agonist
  30. GC32764 GSK-LSD1 Dihydrochloride An LSD1 inhibitor
  31. GC32755 DNQX (FG 9041)

    二硝基喹酮; FG 9041

     A non-NMDA glutamate receptor antagonist
  32. GC32667 Nuvenzepine

    奴文西平

     Nuvenzepine是mAChR的拮抗剂，之前在临床一期试验中用来治疗胃痉挛。
  33. GC32666 Timepidium bromide (Sesden)

    噻哌溴铵,Sesden; SA504

     Timepidium bromide (Sesden) (Sesden; SA504) 是一种抗胆碱能药物。
  34. GC32664 5-HT2A antagonist 1 5-HT2Aantagonist1是来自专利US5728835A和JP1007727的5-HT2A拮抗剂。5-HT2Aantagonist1可能用于治疗心血管疾病的研究。
  35. GC32655 5-HT2 antagonist 1 5-HT2antagonist1是一种有效的5-HT2receptor拮抗剂，同时对α1adrenoceptor有微弱地抑制作用。
  36. GC32644 (4E)-SUN9221 (4E)-SUN9221是一种有效的α1-adrenergicreceptor和5-HT2receptor拮抗剂，具有抗高血压和抗血小板聚集的功效。
  37. GC32640 Pamicogrel (KBT3022)

    帕米格雷; KBT3022

     A COX inhibitor and an antiplatelet agent
  38. GC32637 Tertatolol ((±)-Tertatolol)

    (±)?-?Tertatolol; Racemic Tertatolol; dl-?Tertatolol

     Tertatolol ((±)-Tertatolol) 是一种有效的 β-肾上腺素受体和 5-HT 受体拮抗剂，具有独特的肾血管扩张作用。
  39. GC32615 Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin (human))

    肾上腺髓质素(22-52)(人体),22-52-Adrenomedullin (human)

     Adrenomedullin (AM) (22-52), human是一种NH2末端截断形式的Adrenomedullin (AM)，不具有六元环结构，也不保有降血压和血管舒张活性。
  40. GC32595 PRX933 hydrochloride (GW876167 hydrochloride)

    GW876167 hydrochloride; BVT-933 hydrochloride

     PRX933 hydrochloride (GW876167 hydrochloride) 是一种 5-HT2c 受体激动剂，提取自专利 WO 2014140631 A1。
  41. GC32563 Nexopamil racemate

    奈索帕米

    Nexopamilracemate是Nexopamil的外消旋体。Nexopamil是体内血栓形成和体外血小板聚集中的一种联合Ca2+/5-HT2拮抗剂。
  42. GC32553 CNS-5161 hydrochloride (CNS 5161A)

    CNS 5161A

     CNS-5161 hydrochloride (CNS 5161A) 是一种新型 NMDA 离子通道拮抗剂，可与 NMDA 受体/离子通道位点相互作用，对谷氨酸的作用产生非竞争性阻断。
  43. GC32511 Naftidrofuryl oxalate (Nafronyl oxalate salt)

    萘呋胺酯草酸盐

     Nafronyl oxalate salt is the oxalate salt form of nafronyl, which is a selective antagonist of 5-HT2 receptors and a vasodilator used in the management of peripheral and cerebral vascular disorders.
  44. GC32478 Pirmenol hydrochloride (Cl-845)

    盐酸吡美诺; Cl-845; (±)-Pirmenol hydrochlorid

     A class I antiarrhythmic agent
  45. GC32447 Transcrocetinate disodium (Disodium trans-crocetinate)

    藏红花酸二钠盐,Disodium trans-crocetinate

     从藏红花 (Crocus sativus L.) 中提取的 Transcrocetinate disodium (Disodium trans-crocetinate) 作为 NMDA 受体拮抗剂具有高亲和力。
  46. GC32439 Ferulic acid sodium (Sodium ferulate)

    阿魏酸钠; Coniferic acid sodium

     A phenol with diverse biological activities
  47. GC32416 YM-46303 YM-46303是一种毒蕈碱受体拮抗剂，对M1和M3受体表现出最高的亲和力，对M3受体的选择性较M2受体高。
  48. GC32194 Metrifonate (Trichlorfon)

    Metrifonate是一种不可逆的有机磷乙酰胆碱酯酶抑制剂,用作杀虫剂,控制苍蝇和蟑螂。
  49. GC32185 Dinotefuran (MTI-446)

    呋虫胺; MTI-446

     A neonicotinoid insecticide
  50. GC32050 FRG8701 FRG-8701是一种新组氨酸H2-receptor拮抗剂，IC50值为0.25至0.43μM。
  51. GC32049 Oxitropium Bromide

    氧托溴铵

    Oxitropiumbromide是毒蕈碱受体拮抗剂。它是一种用于治疗哮喘和慢性阻塞性肺疾病的抗胆碱能支气管扩张剂药物。

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