GlpBio

5-HT4 antagonist 1

目录号: GC30314纯度: >98%
COASDSData Sheet
5-HT4antagonist1是一个5-HT4受体拮抗剂，其pKi值为9.6。
5-HT4 antagonist 1
Cas No.: 261766-73-8
规格价格库存数量操作
1mg¥522.00现货
1
5mg¥1,314.00现货
1
10mg¥1,980.00现货
1
25mg¥3,294.00现货
1
50mg¥4,698.00现货
1
10mM (in 1mL DMSO)¥1,390.00现货
1
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文献被引

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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    31, 1291–1307 (2021)

产品描述 Description

5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6.

5-HT4 antagonist 1 (compound 6b) is a 5-HT4 receptor antagonist with a pKi of 9.6.

5-HT4 antagonist 1 (compound 6b) demonstrates good exposure and prolongs t1/2 in other species, including the mouse (t1/2 7 h), rat (t1/2 12 h) and mini-pig (t1/2 21 h). In Phase I clinical trial, it is found that 5-HT4 antagonist 1 has good oral bioavailability with a steady state plasma t1/2 of >100 h[1].

[1]. Clark RD, et al. Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1697-700.

产品文档 Product Documents

Purity:>98%
COASDSData Sheet

化学性质Chemical Properties

CAS 号
261766-73-8
SMILES
O=C(C1=C2OCCOC2=CC=C1)NCC3CCN(CCCS(=O)(N4CCN(C)CC4)=O)CC3
分子式
C23H36N4O5S
分子量
480.62 g/mol
溶解性
DMSO : 20 mg/mL (41.61 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol