Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GC90533 (-)-Pinoresinol
一种具有多种生物活性的木脂素
GC17877 (-)-Quinpirole hydrochloride

(-)-LY 171555
(-)-Quinpirole hydrochloride ((-)-LY 171555) 是一种多巴胺 D2/D3 受体的高亲和力激动剂。
GC46248 (-)-Ropivacaine-d7 (hydrochloride)

(S)-Ropivacaine-d7
An internal standard for the quantification of (–)-ropivacaine
GC30889 (-)-Securinine

一叶秋碱
An alkaloid
GC14252 (-)-Stepholidine

左旋千金藤啶碱,Stepholidine;(-)-Stepholidine;L-SPD
A dopamine receptor antagonist and 5-HT_1A partial agonist
GC70383 (-)-Vesamicol (-)-VesamicolAH5183是乙酰胆碱转运到突触小泡的抑制剂，IC50为75 nM。
GC38677 (-)-α-Pinene

β-蒎烯; (-)-β-Pinene
(-)-α-Pinene 是一种单萜类化合物，通过在 BZD 结合位点作为部分调节剂与 GABAA-苯二氮卓 (BZD) 受体直接结合，显示出增强睡眠的特性。
GC38489 (1α,1'S,4β)-Lanabecestat

(1α,1'S,4β)-AZD3293; (1α,1'S,4β)-LY3314814
(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) 是一种 BACE1 抑制剂，IC50 分别为 2.2 nM (TR-FRET 测定) 和 0.28 nM (sAPPp 释放测定)，详细信息请参考专利文献 WO2012087237A1 中的化合物 20a。
GC16207 (1S,3R)-ACPD

反-(1S,3R)-1-氨基-1,3-环戊烷二羧酸
group I and II mGlu receptor agonist
GC18622 (2'S)-Nicotine-1-oxide

(2'S)-尼古丁氧化物
A nicotine metabolite
GC30544 (2-Chloropyridin-4-yl)methanamine hydrochloride

2-氯-4-氨甲基吡啶; LOXL2-IN-1 hydrochloride
(2-Chloropyridin-4-yl)methanamine hydrochloride是一种高选择性的赖氨酰氧化酶样蛋白-2（LOXL2）抑制剂，其IC₅₀为126nM。
GC11379 (2R,4R)-APDC (2R,4R)-APDC 是一种选择性 II 族代谢型谷氨酸受体 (mGluRs) 激动剂。
GC60000 (2S)-6-Prenylnaringenin

(2S)-6-异戊烯基柚皮素
A prenylated flavonoid with diverse biological activities
GC72813 (3R,5R,6S)-Atogepant

(3R,5R,6S)-MK-8031; (3R,5R,6S)-AGN-241689
(3R,5R,6S)-Atogepant 3R,5R，6S-MK-8031是Atogepant的对映体。
GC32644 (4E)-SUN9221 (4E)-SUN9221是一种有效的α1-adrenergicreceptor和5-HT2receptor拮抗剂，具有抗高血压和抗血小板聚集的功效。
GC41697 (Ala1)-PAR4 (1-6) amide (mouse) (trifluoroacetate salt)

AY-NH2, AYPGKF-NH2, H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2, PAR4-AP, Proteinase-Activated Receptor 4 Activating Peptide
A peptide agonist of PAR4
GC52100 (Arg)9 (trifluoroacetate salt)

Nona-Arginine, Poly-Arginine-9, RRRRRRRRR
A cationic cell-penetrating peptide
GC41699 (Des-octanoyl)-Ghrelin (human) (trifluoroacetate salt) A peptide hormone
GC66255 (E)-3,4,5-Trimethoxycinnamic acid

TMCA
(E)-3,4,5-Trimethoxycinnamic acid (TMCA) 是一种被多甲氧基取代的肉桂酸。(E)-3,4,5-Trimethoxycinnamic acid 是一种口服有效的 GABAA/BZ 受体激动剂。(E)-3,4,5-Trimethoxycinnamic acid 与 5-HT2C 和 5-HT1A 受体具有良好的结合亲和力，其 IC50 值分别为 2.5 和 7.6 μM。(E)-3,4,5-Trimethoxycinnamic acid 具有抗惊厥和镇静活性。(E)-3,4,5-Trimethoxycinnamic acid 可用于失眠、头痛、癫痫的研究。
GC49003 (E)-Ajoene

NSC 614554
A disulfide with diverse biological activities
GC40286 (E,Z)-2-propyl-2-Pentenoic Acid

2-丙基-2-戊烯酸
A valproic acid metabolite
GC41704 (Glp1)-Apelin-13 (trifluoroacetate salt)

(pGlu1)Apelin13, PyrApelin13, (Pyr1)Apelin13
A potent APJ receptor agonist
GC17333 (R)-(+)-8-Hydroxy-DPAT hydrobromide 5-HT1A serotonin receptor agonist
GC69834 (R)-(+)-Dimethindene maleate (R)-(+)-Dimethindene maleate 是一种具有口服活性的 H1-receptor 阻断剂，对猪具有抗组胺性能。
GC41709 (R)-(+)-Docosahexaenyl-1'-Hydroxy-2'-Propylamide A homolog of DHEA
GC41711 (R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide A homolog of LOEA
GC11219 (R)-(+)-Tolterodine

托特罗定; (R)-(+)-Tolterodine; (+)-Tolterodine; (R)-Tolterodine; PNU-200583
(R)-(+)-Tolterodine(PNU-200583) 是一种有效的毒蕈碱受体拮抗剂，在体内对膀胱的选择性优于唾液腺。
GC11809 (R)-(-)-α-Methylhistamine dihydrobromide

(R)-(-)-α-甲基组胺二氢溴酸盐
(R)-(-)-α-Methylhistamine dihydrobromide 是一种有效的、选择性的、可穿透脑的 H3 组胺受体激动剂，Kd 为 50.3 nM。
GC41705 (R)-(-)-Docosahexaenyl-2'-Hydroxy-1'-Propylamide A homolog of DHEA
GC41708 (R)-(-)-Linoleyl-2'-Hydroxy-1'-Propylamide A homolog of LOEA
GC17722 (R)-3,4-DCPG AMPA receptor antagonist with weak activity at NMDA receptors and little activity at kainate receptors
GC14124 (R)-3-Carboxy-4-hydroxyphenylglycine NMDA and AMPA/kainate receptor antagonist
GC46339 (R)-4-Amino-3-hydroxybutyric Acid

(R)-(-)-4-氨基-3-羟基丁酸
A GABA receptor modulator
GC40594 (R)-AM1241

(+)AM1241
A CB₂ receptor agonist and inverse agonist
GC91906 (R)-AS-1 (R)-AS-1是兴奋性氨基酸转运蛋白2 EAAT2的正变构调节剂；谷氨酸摄取试验中的EC50=11nM。
GC14111 (R)-baclofen

(R)-巴氯芬; Arbaclofen; STX209
(R)-巴氯芬 (Arbaclofen) 是一种选择性 GABAB 受体激动剂。
GC34986 (R)-Baclofen hydrochloride

(R)-巴氯芬盐酸盐; Arbaclofen hydrochloride; STX 209 hydrochloride
A GABA_B receptor agonist
GC69805 (R)-Casopitant

(R)-GW679769
(R)-Casopitant ((R)-GW679769) 是 Casopitant 的异构体。Casopitant 是一种 NK(1)-受体拮抗剂。Casopitant 可用于化疗引起的恶心和呕吐的研究。
GC41715 (R)-Cetirizine (hydrochloride)

盐酸左西替利嗪,(R)-Cetirizine dihydrochloride
A selective histamine H₁ receptor antagonist
GC50258 (R)-Citalopram oxalate

(R)-草酸西酞普兰
Enantiomer of escitalopram oxalate
GC41718 (R)-KT109 An inhibitor of DAGLβ, DAGLα, and ABHD6
GC61847 (R)-Lanicemine

(R)-拉尼西明; (R)-AZD6765

(R)-Lanicemine ((R)-AZD6765) 是 Lanicemine 的低活性的 R 型异构体。Lanicemine (AZD6765) 是一种低捕获的 NMDA 受体拮抗剂，Ki 为 0.56-2.1 µM。CHO 和爪蟾卵母细胞中，IC50 分别为 4-7 µM 和 6.4 µM。具有抗抑郁作用。
GC67937 (R)-Mirtazapine

(R)-Org3770; (R)-6-Azamianserin
(R)-Mirtazapine ((R)-Org3770) 是 Mirtazapine 的 R(-)-对映异构体，在急性热伤害感受动物模型中具有抗伤害感受的作用。(R)-Mirtazapine 是 5-HT3 受体拮抗剂，在体内主要经 CYP3A4 代谢。
GC71634 (R)-Oxybutynin hydrochloride (R)-Oxybutynin hydrochloride盐酸奥昔布宁的R-异构体，是一种口服活性毒蕈碱受体拮抗剂。
GC68383 (R)-Preclamol

(+)-3-PPP
(R)-Preclamol 是一种多巴胺 (DA) 激动剂，具有自身受体和突触后受体刺激特性。(R)-Preclamol 以低剂量抑制小鼠和大鼠的运动活动。
GC34993 (R)-Rivastigmine D6 tartrate

酒石酸卡巴拉汀 D6
An internal standard for the quantification of rivastigmine
GC70848 (R)-Safinamide 沙非胺对映体(R)-Safinamide对MAO-B有抑制作用，IC50值为0.45 μM。
GC18238 (R)-γ-Valerolactone

(R)-二氢-5-甲基-2(3H)-呋喃酮
(R)-γ-Valerolactone是一种五元环内酯，可用作生物制药和生物塑料的前体，价值高于生物燃料。
GC34995 (R,R)-Palonosetron Hydrochloride

(R,R)-盐酸帕洛诺司琼
(R,R)-Palonosetron Hydrochloride 是一个有活性的 Palonosetron 对映异构体。
GC16032 (R,S)-Anatabine

新烟草碱(去氢新烟碱)
A minor tobacco alkaloid