PPM1D Human
目录号 : GP22134Protein Phosphatase 1D Human Recombinant
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| Purity | Greater than 90.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Protein phosphatase 1D magnesium-dependent; delta isoform; PPM1D; Protein Phosphatase 1D; PP2C-DELTA; WIP1. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MVAFFAVCDG HGGREAAQFA REHFWGFIKK QKGFTSSEPA KVCAAIRKGF LACHLAMWKK LAEWPKTMTG LPSTSGTTAS VVIIRGMKMY VAHVGDSGVV LGIQDDPKDD FVRAVEVTQD HKPELPKERE RIEGLGGSVM NKSGVNRVVW KRPRLTHNGP VRRSTVIDQI PFLAVARALG DLWSYDFFSG EFVVSPEPDT SVHTLDPQKH KYIILGSDGL WNMIPPQDAI SMCQDQEEKK YLMGEHGQSC AKMLVNRALG RWRQRMLRAD NTSAIVICI. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | PPM1D protein solution (0.5mg/ml) containing 20mM Tris-HCl (pH8.0) and 10% glycerol. | ||
ProteinPhosphatase 1D (PPM1D) belongs to the PP2C family of Ser/Thr proteinphosphatases whose members are negative regulators of cell stress responsepathways. PPM1D is induced by tumor suppressor protein TP53/p53 in response to multipleenvironmental stresses. PPM1D is a negative regulator of the activity of p38MAP kinase through which it reduces the phosphorylation of p53 and suppressesp53-mediated transcription and apoptosis. PPM1D is located in a chromosomal areawhich enlarges in breast cancer.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.