GlpBio

Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

研究方向

Chromatin/Epigenetics 相关产品(1617)

  • GC12917 structure
    GC12917Acetaminophen
    CAS: 103-90-2
    纯度: >99.00%

    An analgesic and antipyretic compound

  • GC12934 structure
    GC12934YM 750
    CAS: 138046-43-2
    纯度: >98.00%

    YM 750 是一种有效的 acyl-CoA:cholesterol acyltransferase (ACAT) 抑制剂 (IC50\u003d0.18 μM)。

  • GC12971 structure
    GC12971CAY10603
    CAS: 1045792-66-2
    纯度: >99.50%

    An exceptionally potent inhibitor of HDAC6

  • GC12976 structure
    GC12976Suberohydroxamic Acid
    CAS: 38937-66-5

    HDAC inhibitor

  • GC12997 structure
    GC12997GSK J4 free base
    CAS: 1373423-53-0
    纯度: >99.50% / >98.00%

    GSK J4 free base 是 H3K27me3/me2-去甲基化酶 JMJD3/KDM6B 和 UTX/KDM6A 的有效双重抑制剂，IC50 分别为 8.6 和 6.6 μM。 GSK J4 游离碱抑制 LPS 诱导的 TNF-α；在人原代巨噬细胞中产生，IC50 为 9 μM. GSK J4 是 GSK-J1 的细胞渗透性前药。 GSK J4 free base 诱导内质网应激相关的细胞凋亡。

  • GC13014 structure
    GC13014AZD 5153
    CAS: 1869912-39-9

    AZD 5153是BET/BRD4溴结构域的双价抑制剂，AZD 5153对BRD4的IC₅₀值为5nM，可同时结合BRD4的两个溴结构域，显著影响MYC、E2F和mTOR的转录程序，并抑制NSD3靶基因的表达。

  • GC13025 structure
    GC13025GSK6853
    CAS: 1910124-24-1
    纯度: >99.00%

    A selective chemical probe for the bromodomain of BRPF1

  • GC13062 structure
    GC13062JGB1741
    CAS: 1256375-38-8

    A SIRT1 inhibitor

  • GC13086 structure
    GC13086GSK J2
    CAS: 1394854-52-4
    纯度: >99.50%

    A negative control compound for GSK-J1

  • GC13088 structure
    GC13088BRD6688
    CAS: 1404562-17-9

    A kinetically selective HDAC2 inhibitor

  • GC13102 structure
    GC13102XL228
    CAS: 898280-07-4
    纯度: >99.00%

    A tyrosine kinase inhibitor

  • GC13148 structure
    GC13148MS436
    CAS: 1395084-25-9
    纯度: >99.00%

    MS436 是一类新的溴结构域抑制剂，对 BRD4 BrD1 具有估计的 Ki=30-50 nM 的强亲和力，对 BrD2 的选择性是 10 倍。

  • GC13187 structure
    GC13187I-BET 151 hydrochloride

    A BRD2, BRD3, and BRD4 inhibitor

  • GC13198 structure
    GC13198AMG-900
    CAS: 945595-80-2
    纯度: >98.00%

    A selective pan-Aurora kinase inhibitor

  • GC13249 structure
    GC13249Rucaparib (free base)
    CAS: 283173-50-2
    纯度: >99.00%

    Rucaparib (free base)是一种口服生物可利用的三环吲哚类聚（ADP-核糖）聚合酶（PARP）抑制剂。

  • GC13332 structure
    GC13332Aurora A Inhibitor I
    CAS: 1158838-45-9
    纯度: >99.00%

    A potent and selective inhibitor of Aurora A kinase

  • GC13417 structure
    GC13417EX-527 S-enantiomer
    CAS: 848193-68-0
    纯度: >98.50%

    EX-527 S-对映异构体 ((S)-EX-527) 是一种有效的选择性 SIRT1 抑制剂，IC50 为 98 nM。

  • GC13419 structure
    GC13419ME0328
    CAS: 1445251-22-8
    纯度: >99.50%

    A selective PARP3 inhibitor

  • GC13435 structure
    GC13435KD 5170
    CAS: 940943-37-3

    An inhibitor of class I and II HDACs

  • GC13442 structure
    GC13442Sanguinarine chloride
    CAS: 5578-73-4
    纯度: >99.00%

    A natural alkaloid with anti-inflammatory and anti-oxidant properties

  • GC13474 structure
    GC13474Garcinol
    CAS: 78824-30-3
    纯度: >95.00%

    Garcinol是组蛋白乙酰转移酶p300和PCAF的非特异性抑制剂，IC 50 分别为7μM和5μM。

  • GC13534 structure
    GC13534Lysine-specific Demethylase Inhibitor (1C)
    CAS: 927019-63-4

    lysine-specific demethylase Inhibitor

  • GC13541 structure
    GC13541G007-LK
    CAS: 1380672-07-0
    纯度: >99.00%

    G007-LK是一种有效的、选择性的TNKS1（IC 50 =46nM）和TNKS2（IC 50 =25nM）抑制剂。

  • GC13634 structure
    GC13634(S)-PFI-2 (hydrochloride)
    CAS: 1627607-88-8

    Negative control of (R)-PFI 2