GlpBio

Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

研究方向

Chromatin/Epigenetics 相关产品(1617)

  • GC12171 structure
    GC12171BIX 01294
    CAS: 935693-62-2
    纯度: >99.50%

    An inhibitor of G9a histone methyltransferase

  • GC12189 structure
    GC12189LB-100
    CAS: 1026680-07-8

    A PP2A inhibitor with anticancer activity

  • GC12199 structure
    GC12199MI-3
    CAS: 1271738-59-0
    纯度: >98.00%

    An inhibitor of menin-MLL fusion protein interactions

  • GC12255 structure
    GC12255IOX4
    CAS: 1154097-71-8
    纯度: >99.50%

    A selective, bioavailable inhibitor of HIF-PH2

  • GC12288 structure
    GC12288GSK-J1 sodium salt
    CAS: 1797832-71-3

    A dual inhibitor of JMJD3 and UTX

  • GC12337 structure
    GC12337Tenovin-3
    CAS: 1011301-27-1
    纯度: >99.50%

    A small molecule activator of p53

  • GC12359 structure
    GC12359Hispidulin
    CAS: 1447-88-7
    纯度: >99.00%

    A flavonoid with diverse biological activities

  • GC12367 structure
    GC12367CM-272
    CAS: 1846570-31-7
    纯度: >98.00%

    An inhibitor of G9a, GLP, and DNA methyltransferases

  • GC12440 structure
    GC12440GSK 5959
    CAS: 901245-65-6
    纯度: >98.00%

    An inhibitor of the BRPF1 bromodomain

  • GC12450 structure
    GC12450BI 2536
    CAS: 755038-02-9
    纯度: >99.50% / >98.00%

    BI 2536是一种双重Polo样激酶（PLK）/溴结构域抑制剂，在无细胞激酶实验中，BI 2536 对PLK1、PLK2和PLK3的半数抑制浓度（IC 50 ）值分别为0.83nM、3.5nM和9.0nM。

  • GC12458 structure
    GC12458N-Oxalylglycine
    CAS: 5262-39-5

    An inhibitor of JMJD2 histone demethylases

  • GC12484 structure
    GC12484BRD73954
    CAS: 1440209-96-0
    纯度: >98.00%

    A dual inhibitor of HDAC6 and HDAC8

  • GC12496 structure
    GC12496INO-1001
    CAS: 3544-24-9
    纯度: >99.50%

    A PARP inhibitor

  • GC12498 structure
    GC12498Sephin1
    CAS: 13098-73-2
    纯度: >99.50%

    A selective inhibitor of the phosphatase regulatory subunit PPP1R15A

  • GC12557 structure
    GC12557ML324
    CAS: 1222800-79-4
    纯度: >98.50%

    A cell-permeable inhibitor of JMJD2 demethylases

  • GC12588 structure
    GC12588I-BRD9
    CAS: 1714146-59-4
    纯度: >99.50%

    A BRD9 bromodomain inhibitor

  • GC12630 structure
    GC12630MS37452
    CAS: 423748-02-1

    An inhibitor of CBX7 chromodomain binding to H3K27me3

  • GC12660 structure
    GC12660AZD1208
    CAS: 1204144-28-4
    纯度: >98.00%

    AZD1208 是一种有效、高选择性且可口服的 Pim 激酶抑制剂，对 PIM1、PIM2 和 PIM3 的 IC50 值分别为 0.4、5 和 1.9nM。

  • GC12775 structure
    GC127752',3',5'-triacetyl-5-Azacytidine
    CAS: 10302-78-0

    A prodrug form of 5-azacytidine

  • GC12821 structure
    GC12821Oltipraz
    CAS: 64224-21-1
    纯度: >99.50%

    A Nrf2 and CAR activator

  • GC12822 structure
    GC12822BML-210(CAY10433)
    CAS: 537034-17-6

    A potent, synthetic HDAC inhibitor

  • GC12869 structure
    GC12869JW 55
    CAS: 664993-53-7
    纯度: >99.50%

    A TNKS1/2 inhibitor

  • GC12874 structure
    GC12874SGC707
    CAS: 1687736-54-4
    纯度: >99.00% / >98.00%

    A potent allosteric inhibitor of PRMT3

  • GC12891 structure
    GC12891CCT007093
    CAS: 176957-55-4
    纯度: >98.00%

    An inhibitor of PPM1D