GlpBio

Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

研究方向

Chromatin/Epigenetics 相关产品(1617)

  • GC11414 structure
    GC11414GSK503
    CAS: 1346572-63-1
    纯度: >99.50%

    A potent, selective EZH2 inhibitor

  • GC11418 structure
    GC11418MI-2
    CAS: 1271738-62-5
    纯度: >99.00%

    An inhibitor of menin-MLL fusion protein interactions

  • GC11430 structure
    GC11430Remodelin
    CAS: 1622921-15-6
    纯度: >98.00%

    Remodelin 是 N-乙酰转移酶 10 (NAT10) 的小分子抑制剂。

  • GC11439 structure
    GC11439MG 149
    CAS: 1243583-85-8
    纯度: >99.50% / >98.00%

    MG 149是一种组蛋白乙酰转移酶（HAT）抑制剂，对Tip60和MOF的IC 50 值分别为74μM和47μM。

  • GC11539 structure
    GC11539CI 976
    CAS: 114289-47-3

    An inhibitor of ACAT-1

  • GC11548 structure
    GC11548Tankyrase Inhibitors (TNKS) 49

    Tankyrase inhibitor

  • GC11561 structure
    GC11561NSC 95397
    CAS: 93718-83-3
    纯度: >98.00%

    An irreversible inhibitor of Cdc25 isoforms

  • GC11578 structure
    GC11578GSK2879552
    CAS: 1401966-69-5
    纯度: >99.50%

    An LSD1 inhibitor

  • GC11641 structure
    GC11641Boc-Lys(Ac)-AMC
    CAS: 233691-67-3
    纯度: >99.00%

    A fluorogenic HDAC substrate

  • GC11652 structure
    GC11652CHZ868
    CAS: 1895895-38-1
    纯度: >99.00%

    CHZ868 是一种 II 型 JAK2 抑制剂，在 EPOR JAK2 WT Ba/F3 细胞中的 IC50 为 0.17 μM。

  • GC11716 structure
    GC11716SIRT1/2 Inhibitor IV
    CAS: 14513-15-6
    纯度: >99.00%

    Cell-permeable inhibitor of SIRT1 and SIRT2

  • GC11767 structure
    GC11767Hydralazine HCl
    CAS: 304-20-1
    纯度: >99.50%

    An antihypertensive agent

  • GC11792 structure
    GC11792OG-L002 HCl
    CAS: 1357298-75-9

    An LSD1 inhibitor

  • GC11806 structure
    GC11806β-Glycerophosphate (sodium salt hydrate)
    CAS: 13408-09-8
    纯度: >98.00%

    An inhibitor of alkaline phosphatase

  • GC11873 structure
    GC118732,4-Pyridinedicarboxylic Acid
    CAS: 499-80-9
    纯度: >99.00%

    An inhibitor of 2-oxoglutarate-dependent enzymes

  • GC11972 structure
    GC11972NU 9056
    CAS: 1450644-28-6
    纯度: >98.00%

    NU 9056（1，2-双（异噻唑-5-基）二硫烷）是一种有效且选择性的Tip60（KAT5） 组蛋白乙酰转移酶（HAT）抑制剂，IC 50 值为2μM，具有抗肿瘤活性。

  • GC11990 structure
    GC11990TCS-PIM-1-4a
    CAS: 327033-36-3
    纯度: >99.50%

    TCS-PIM-1-4a (SMI-4a) 是一种泛 Pim 激酶抑制剂，通过激活 AMPK 来阻断 mTORC1 的活性。 TCS-PIM-1-4a 可杀死多种髓系和淋巴系细胞系（IC50 值范围为 0.8 μM 至 40 μM）。

  • GC12005 structure
    GC12005C7280948
    CAS: 587850-67-7
    纯度: >98.00%

    A PRMT1 inhibitor

  • GC12009 structure
    GC12009HAT Inhibitor II
    CAS: 932749-62-7
    纯度: >99.00%

    An inhibitor of HAT p300

  • GC12020 structure
    GC12020TCS 401
    CAS: 243966-09-8
    纯度: >98.00%

    A selective PTP1B inhibitor

  • GC12074 structure
    GC12074BG45
    CAS: 926259-99-6
    纯度: >99.50%

    A selective HDAC3 inhibitor

  • GC12082 structure
    GC12082Cantharidic Acid (sodium salt)
    CAS: 1465-77-6

    A protein phosphatase inhibitor

  • GC12115 structure
    GC12115CUDC-907
    CAS: 1339928-25-4
    纯度: >99.50%

    CUDC 是一种口服生物可利用的小分子 PI3K 和 HDAC 双重抑制剂，作用于 PI3K α 和 HDAC1 / 2 / 3 / 10，IC50 分别为 19 nm 和 1.7 nm / 5 nm / 1.8 nm / 2.8 nm .在 WSU DLCL2 细胞中评估了双功能 HDAC 和 PI3K 抑制剂 CUDC-907 的抗肿瘤活性。

  • GC12145 structure
    GC12145ENMD-2076 L-(+)-Tartaric acid
    CAS: 1291074-87-7
    纯度: >98.50%

    ENMD-2076 L-(+)-Tartaric acid 是一种多靶点激酶抑制剂，对 Aurora A、Flt3、KDR/VEGFR2、Flt4/VEGFR3、FGFR1 的 IC50 为 1.86、14、58.2、15.9、92.7、70.8、56.4 nM , FGFR2, Src, PDGFRα, 分别。