GlpBio

Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

研究方向

Chromatin/Epigenetics 相关产品(1617)

  • GC10382 structure
    GC10382CPI-637
    CAS: 1884712-47-3
    纯度: >99.50%

    An inhibitor of CBP/EP300 bromodomains

  • GC10402 structure
    GC10402Bromosporine
    CAS: 1619994-69-2
    纯度: >99.50%

    A non-specific bromodomain inhibitor

  • GC10408 structure
    GC104082-D08
    CAS: 144707-18-6
    纯度: >98.00%

    2-D08是一种合成黄酮和具有细胞通透性的小泛素样修饰蛋白（SUMO）抑制剂，也能抑制Axl靶点，IC 50 为0.49nM。

  • GC10417 structure
    GC10417ACY-241
    CAS: 1316215-12-9
    纯度: >98.50%

    An HDAC6 inhibitor

  • GC10423 structure
    GC10423RG2833
    CAS: 1215493-56-3
    纯度: >98.00%

    An HDAC inhibitor

  • GC10456 structure
    GC10456Fucosterol
    CAS: 17605-67-3
    纯度: >98.00%

    A natural phytosterol with diverse biological activities

  • GC10555 structure
    GC10555Splitomicin
    CAS: 5690-03-9
    纯度: >98.00%

    Inhibitor of yeast Sir2p

  • GC10638 structure
    GC10638AT9283
    CAS: 896466-04-9
    纯度: >99.50%

    A broad spectrum kinase inhibitor

  • GC10727 structure
    GC10727Ischemin sodium salt

    CBP bromodomain inhibitor

  • GC10770 structure
    GC10770Decernotinib(VX-509)
    CAS: 944842-54-0

    A selective JAK3 inhibitor

  • GC10774 structure
    GC10774CPI-455
    CAS: 1628208-23-0
    纯度: >98.50% / >98.00%

    CPI-455是一种KDM5抑制剂，KDM5（Kissinger Demethylase 5）是一种赖氨酸特异性脱甲基酶，在染色质修饰中起着至关重要的作用，并参与各种生物学过程，包括肿瘤发展和免疫反应。

  • GC10839 structure
    GC10839Tubastatin A
    CAS: 1252003-15-8
    纯度: >98.00%

    Tubastatin A 是一种有效的选择性 HDAC6 抑制剂，IC 50 值为 15 nM。并且Tubastatin A也是一种新型GPX4抑制剂，Tubastatin A 直接与 GPX4 结合，诱导乳腺癌细胞铁死亡。

  • GC10898 structure
    GC108985-(N,N-dimethyl)-Amiloride (hydrochloride)
    CAS: 2235-97-4
    纯度: >98.00%

    An inhibitor of Na + /H + exchangers

  • GC10905 structure
    GC10905Amodiaquine dihydrochloride dihydrate
    CAS: 6398-98-7
    纯度: >99.50%

    A prodrug form of N-desethyl amodiaquine

  • GC10931 structure
    GC10931VULM 1457
    CAS: 228544-65-8

    VULM 1457 是一种有效的胆固醇酰基转移酶 (acyl-CoA) 抑制剂。

  • GC10979 structure
    GC10979PFI 4
    CAS: 900305-37-5
    纯度: >98.00%

    A chemical probe for BRPF1

  • GC10995 structure
    GC10995PJ34
    CAS: 344458-19-1
    纯度: >98.00%

    PJ34是一种有效且特异性的PARP抑制剂，IC 50 值为110nM。

  • GC11031 structure
    GC11031PX-478 2HCl
    CAS: 685898-44-6
    纯度: >98.00%

    PX-478是一种选择性抑制剂，可以抑制常规和低氧诱导的HIF-1α水平。

  • GC11085 structure
    GC11085TAK-901
    CAS: 934541-31-8
    纯度: >98.00%

    A non-selective inhibitor of Aurora kinases

  • GC11209 structure
    GC11209Cerdulatinib (PRT062070)
    CAS: 1198300-79-6
    纯度: >99.50%

    A dual inhibitor of Syk and JAKs

  • GC11249 structure
    GC112492-hexyl-4-Pentynoic Acid
    CAS: 96017-59-3

    An HDAC inhibitor

  • GC11302 structure
    GC11302Hinokitiol
    CAS: 499-44-5
    纯度: >99.50% / >98.00%

    Hinokitiol是一种在 Formosan cypress 中天然存在的tropolone类化合物，具有抗菌和抗癌特性。

  • GC11340 structure
    GC11340(R)-PFI 2 hydrochloride
    CAS: 1627607-87-7
    纯度: >99.50%

    A SET7/9 inhibitor

  • GC11381 structure
    GC11381Tautomycetin
    CAS: 119757-73-2
    纯度: >98.00%

    Tautomycetin 是一种有效的特异性 PP1 抑制剂，具有潜在的细胞凋亡诱导活性。