GlpBio

Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

研究方向

Chromatin/Epigenetics 相关产品(1617)

  • GC18153 structure
    GC18153WM-8014
    CAS: 2055397-18-5
    纯度: >99.50%

    An inhibitor of KAT6A and KAT6B

  • GC18154 structure
    GC18154WM-1119
    CAS: 2055397-28-7
    纯度: >99.50%

    WM-1119是一种强效KAT6抑制剂，IC 50 值为6.3μM，对KAT6A、KAT5和KAT7的K D 值分别为0.002μM、2.2μM和0.5μM。

  • GC18159 structure
    GC18159BAY-598
    CAS: 1906919-67-2
    纯度: >99.50%

    BAY-598是一种氨基吡唑啉基的选择性小分子抑制剂，靶点为含有SET和MYND结构域的蛋白2（SMYD2），半抑制浓度（IC 50 ）为27nM。

  • GC18925 structure
    GC18925Cl-Amidine (hydrochloride)
    CAS: 1373232-26-8
    纯度: >98.50%

    A PAD inhibitor

  • GC19184 structure
    GC19184GSK484 hydrochloride
    CAS: 1652591-81-5
    纯度: >98.00%

    GSK484是一种选择性PAD4抑制剂，已被用作抗缺血化合物，对PAD4具有抑制活性。

  • GC31755 structure
    GC31755BB-Cl-Amidine
    CAS: 1802637-39-3

    BB-Cl-Amidine 是一种肽基精氨酸脱氨酶 (PAD) 抑制剂，常用于研究 PAD 功能。

  • GC32303 structure
    GC32303Streptonigrin (Bruneomycin)
    CAS: 3930-19-6

    A phenylpyridylquinoline with diverse biological activities

  • GC33261 structure
    GC33261YW3-56
    CAS: 1374311-17-7

    YW3-56是有效的肽酰精氨酸脱亚胺酶(PAD)抑制剂，其对PAD4的IC50值为1-5μM。

  • GC35480 structure
    GC35480BB-Cl-Amidine hydrochloride
    CAS: 2436747-41-8
    纯度: >99.00%

    A PAD4 inhibitor

  • GC35706 structure
    GC35706Cl-amidine
    CAS: 913723-61-2
    纯度: >98.00% / >97.00%

    Cl-amidine is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively. Cl-amidine induces apoptosis.

  • GP10020 structure
    GP10020Histone-H2A-(107-122)-Ac-OH

    Histone-H2A peptide

  • GA20481 structure
    GA20481Ac-Arg-Gly-Lys(Ac)-AMC
    CAS: 660846-97-9
    纯度: >98.00%

    Ac-Arg-Gly-Lys(Ac)-AMC 是 HDAC 的底物。

  • GA20605 structure
    GA20605Ac-Lys-AMC
    CAS: 156661-42-6
    纯度: >98.00%

    Ac-Lys-AMC（己酰胺），也称为 MAL，是组蛋白去乙酰化酶 HDAC 的荧光底物。

  • GC10008 structure
    GC10008GSK1070916
    CAS: 942918-07-2
    纯度: >98.50%

    A potent inhibitor of Aurora B and C kinases

  • GC10021 structure
    GC10021CPI-360
    CAS: 1802175-06-9
    纯度: >99.00%

    A selective EZH2 inhibitor

  • GC10046 structure
    GC10046Molidustat (BAY85-3934)
    CAS: 1154028-82-6
    纯度: >99.00%

    A pan-HIF-PH inhibitor

  • GC10099 structure
    GC10099MS023
    CAS: 1831110-54-3
    纯度: >98.00%

    MS023 是 I 型蛋白精氨酸甲基转移酶 (PRMT) 的有效、选择性和细胞活性抑制剂。

  • GC10148 structure
    GC10148RN 1 dihydrochloride
    CAS: 1781835-13-9
    纯度: >98.00%

    An irreversible LSD1 inhibitor

  • GC10174 structure
    GC10174SGC-CBP30
    CAS: 1613695-14-9
    纯度: >99.50%

    A potent inhibitor of CREBBP/EP300 bromodomains

  • GC10226 structure
    GC10226Butyrolactone 3
    CAS: 778649-18-6
    纯度: >95.00% / >98.00%

    Butyrolactone 3是组蛋白乙酰转移酶GCN5的小分子抑制剂（IC 50 = 100μM）。

  • GC10243 structure
    GC10243Nanaomycin C
    CAS: 58286-55-8

    Amide of nanaomycin A

  • GC10259 structure
    GC10259BRD4770
    CAS: 1374601-40-7
    纯度: >99.50%

    An inhibitor of EHMT2/G9a

  • GC10319 structure
    GC10319TC-E 5002
    CAS: 1453071-47-0
    纯度: >98.00%

    A KDM2/7 inhibitor

  • GC10341 structure
    GC10341Peficitinb (ASP015K, JNJ-54781532)
    CAS: 944118-01-8
    纯度: >98.00%

    A JAK inhibitor