GlpBio

Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

研究方向

Chromatin/Epigenetics 相关产品(1617)

  • GC13668 structure
    GC13668Phthalazinone pyrazole
    CAS: 880487-62-7

    Potent, selective inhibitor of Aurora kinase A

  • GC13706 structure
    GC13706Droxinostat
    CAS: 99873-43-5
    纯度: >99.50%

    An inhibitor of HDAC3, HDAC6, and HDAC8

  • GC13822 structure
    GC13822(-)-JQ1
    CAS: 1268524-71-5
    纯度: >99.50%

    A selective inhibitor of BET bromodomains

  • GC13837 structure
    GC13837SNS-314 Mesylate
    CAS: 1146618-41-8
    纯度: >99.50%

    A pan-Aurora kinase inhibitor

  • GC13848 structure
    GC13848LY2784544
    CAS: 1229236-86-5
    纯度: >99.50%

    Potent inhibitor of JAK2

  • GC13919 structure
    GC13919Tranylcypromine hydrochloride
    CAS: 1986-47-6

    An irreversible, mechanism-based inhibitor of LSD1

  • GC13942 structure
    GC13942SirReal2
    CAS: 709002-46-0
    纯度: >99.00%

    A selective SIRT2 inhibitor

  • GC14016 structure
    GC14016Sulforaphane
    CAS: 4478-93-7
    纯度: >98.00% / >99.00% / >97.00%

    萝卜硫素 (SFN) 称为 [1-isothiocyanato-4-(methylsulfinyl)butane]。

  • GC14062 structure
    GC14062EPZ-6438
    CAS: 1403254-99-8
    纯度: >98.00% / >98.50% / >99.00%

    EPZ-6438 是一种有效且具有生物利用度的 EZH2 抑制剂，EZH2 是多梳抑制复合物 2 (PRC2) 的催化亚基，可催化组蛋白 H3 (H3K27) 的赖氨酸 27 甲基化，从而抑制含有人 PRC2 的活性抑制常数 K i 值为 2.5 nM 的野生型 EZH2。

  • GC14063 structure
    GC14063GSK1324726A
    CAS: 1300031-52-0
    纯度: >98.00%

    A selective inhibitor of BET family proteins

  • GC14066 structure
    GC14066Procaine
    CAS: 59-46-1
    纯度: >99.00%

    An Analytical Reference Standard

  • GC14103 structure
    GC14103NSC228155
    CAS: 113104-25-9
    纯度: >98.00%

    An EGFR activator and inhibitor of KID-KIX interactions

  • GC14168 structure
    GC14168UMB-32
    CAS: 1635437-39-6

    An inhibitor of BRD4, TAF1, and TAF1L bromodomains

  • GC14199 structure
    GC14199RVX-208
    CAS: 1044870-39-4
    纯度: >99.00%

    A selective BET bromodomain antagonist

  • GC14240 structure
    GC14240MS049 (hydrochloride)
    CAS: 2095432-59-8

    A selective, dual PRMT4/PRMT6 inhibitor

  • GC14249 structure
    GC14249UNC 0642
    CAS: 1481677-78-4
    纯度: >99.50%

    A G9a histone methyltransferase inhibitor

  • GC14282 structure
    GC14282AKBA (3-acetyl-11-keto-β-Boswellic Acid)
    CAS: 67416-61-9
    纯度: >98.00%

    AKBA (3-acetyl-11-keto-β-Boswellic Acid)是一种五环三萜酸，能够有效地非竞争性地抑制5-脂氧合酶（5-lipoxygenase, 5-LOX），具有抗炎、抗肿瘤、神经保护等多种生物活性。

  • GC14285 structure
    GC14285RGFP966
    CAS: 1357389-11-7
    纯度: >99.50% / >98.00%

    RGFP966是一种N-(o-aminophenyl)carboxamide HDAC抑制剂，对HDAC3的IC50为0.08 μM，是一类针对HDAC3的慢开/慢关竞争性紧密结合抑制剂。

  • GC14361 structure
    GC14361PFI 3
    CAS: 1819363-80-8
    纯度: >98.00%

    Probe for bromodomains of SMARCA2/4 and PB1(bromodomain 5)

  • GC14362 structure
    GC14362Lin28 1632
    CAS: 108825-65-6

    An inhibitor of the Lin28/let-7 interaction

  • GC14364 structure
    GC14364SGI-1027
    CAS: 1020149-73-8
    纯度: >99.00%

    A DNA methyltransferase inhibitor

  • GC14367 structure
    GC14367UF 010
    CAS: 537672-41-6
    纯度: >99.50%

    A class I HDAC inhibitor

  • GC14380 structure
    GC14380BGP-15
    CAS: 66611-37-8
    纯度: >98.00%

    A PARP inhibitor and insulin sensitizer

  • GC14428 structure
    GC14428CPTH2 (hydrochloride)
    CAS: 2108899-91-6

    A HAT inhibitor