GlpBio

Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

研究方向

Chromatin/Epigenetics 相关产品(1617)

  • GC14439 structure
    GC14439Santacruzamate A (CAY10683)
    CAS: 1477949-42-0
    纯度: >99.00%

    Santacruzamate A (CAY10683)是一种天然氨基甲酸酯衍生物，可抑制HDAC2和HDAC6活性，IC 50 值分别为0.119nM和434nM。

  • GC14524 structure
    GC14524CTPB
    CAS: 586976-24-1
    纯度: >98.00%

    A selective activator of p300 HAT

  • GC14566 structure
    GC14566CCT137690
    CAS: 1095382-05-0
    纯度: >99.00%

    An inhibitor of Aurora kinases and FLT3

  • GC14585 structure
    GC14585GSK591
    CAS: 1616391-87-7
    纯度: >99.50%

    A chemical probe for PRMT5

  • GC14592 structure
    GC14592KW 2449
    CAS: 1000669-72-6
    纯度: >99.50%

    A multi-kinase inhibitor

  • GC14597 structure
    GC14597ITSA-1 (ITSA1)
    CAS: 200626-61-5
    纯度: >98.00%

    ITSA-1 (ITSA1)是一种组蛋白去乙酰化酶（HDAC）激活剂，可以防止动脉层流剪切力诱导的内皮细胞脱落，并降低血管内皮细胞（vECs）中VCAM-1的表达。

  • GC14631 structure
    GC14631SP2509
    CAS: 1423715-09-6
    纯度: >99.50%

    A reversible inhibitor of LSD1

  • GC14655 structure
    GC14655OXF BD 02
    CAS: 1429129-68-9

    OXF BD 02 是 BRD4(1)（BRD4 的第一个溴结构域）的选择性抑制剂，IC50 值为 382 nM。

  • GC14676 structure
    GC14676Pacritinib (SB1518)
    CAS: 937272-79-2

    An equipotent inhibitor of FLT3 and JAK2

  • GC14686 structure
    GC14686JFD00244
    CAS: 96969-83-4
    纯度: >98.00%

    An inhibitor of SIRT2

  • GC14699 structure
    GC14699CPI-203
    CAS: 1446144-04-2
    纯度: >99.00%

    A bioavailable inhibitor of BET bromodomains

  • GC14755 structure
    GC14755Inauhzin
    CAS: 309271-94-1
    纯度: >99.00%

    A selective SIRT1 inhibitor

  • GC14756 structure
    GC14756EI1
    CAS: 1418308-27-6
    纯度: >99.50%

    A selective inhibitor of EZH2

  • GC14763 structure
    GC14763WDR5 0103
    CAS: 890190-22-4
    纯度: >98.00%

    An inhibitor of WDR5 peptide binding

  • GC14787 structure
    GC14787Curcumin
    CAS: 458-37-7
    纯度: >98.00%

    A yellow pigment with diverse biological activities

  • GC14857 structure
    GC14857LFM-A13
    CAS: 244240-24-2
    纯度: >99.50%

    A BTK inhibitor

  • GC14875 structure
    GC14875NSC 663284
    CAS: 383907-43-5
    纯度: >99.50%

    Inhibitor of Cdc25 isoforms

  • GC14938 structure
    GC14938PF-03394197(Oclacitinib)
    CAS: 1208319-26-9

    A JAK family kinase inhibitor

  • GC14998 structure
    GC14998Rocilinostat (ACY-1215)
    CAS: 1316214-52-4
    纯度: >98.00%

    A selective inhibitor of HDAC6

  • GC15041 structure
    GC15041Tankyrase Inhibitors (TNKS) 22

    Tankyrase inhibitor

  • GC15049 structure
    GC15049MCB-613
    CAS: 1162656-22-5
    纯度: >99.50%

    A small molecule stimulator of SRCs

  • GC15102 structure
    GC15102EPZ020411
    CAS: 1700663-41-7
    纯度: >98.00%

    EPZ020411是一种具有高效选择性，且口服生物利用度高的蛋白质精氨酸甲基转移酶6（PRMT6）抑制剂，IC 50 值为10nM。

  • GC15104 structure
    GC15104(R)-(+)-Etomoxir sodium salt
    CAS: 828934-41-4
    纯度: >99.00%

    (R)-(+)-Etomoxir sodium salt(Etomoxir; ETO)是一种用于代谢和心血管疾病的小分子,经酶转化为活性抑制剂乙托莫西里尔辅酶a (IC50 约为0.01-0.70 µM)后,对CPT-1a和CPT-1b的抑制表现出纳摩尔效价。

  • GC15106 structure
    GC15106CYC116
    CAS: 693228-63-6
    纯度: >98.00%

    A potent Aurora kinase inhibitor