GlpBio

Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

研究方向

Chromatin/Epigenetics 相关产品(1617)

  • GC15120 structure
    GC15120PTP Inhibitor I
    CAS: 2491-38-5
    纯度: >98.00%

    A SHP-1(ΔSH2) and PTP1B inhibitor

  • GC15152 structure
    GC15152PF-CBP1
    CAS: 1962928-21-7

    An inhibitor of the CBP and p300 bromodomains

  • GC15175 structure
    GC15175BAZ2-ICR
    CAS: 1665195-94-7
    纯度: >98.50%

    A BAZ2A/B bromodomain inhibitor

  • GC15301 structure
    GC15301PBIT
    CAS: 2514-30-9
    纯度: >98.00% / >99.50%

    An inhibitor of JARID1 family demethylases

  • GC15302 structure
    GC15302EPZ015666
    CAS: 1616391-65-1
    纯度: >99.00%

    EPZ015666是一种新型的选择性蛋白精氨酸甲基转移酶5（PRMT5）抑制剂，IC 50 值< 10nM。

  • GC15368 structure
    GC15368GSK-LSD1 2HCl
    CAS: 1431368-48-7

    不可逆的、选择性的 LSD1 抑制剂

  • GC15375 structure
    GC15375PFI-1 (PF-6405761)
    CAS: 1403764-72-6
    纯度: >99.50%

    A BET bromodomain inhibitor

  • GC15379 structure
    GC15379JNJ-42041935
    CAS: 1193383-09-3
    纯度: >99.50%

    A selective inhibitor of HIF-PH enzymes

  • GC15410 structure
    GC15410Bufexamac
    CAS: 2438-72-4
    纯度: >98.00%

    An NSAID and a class IIb HDAC inhibitor

  • GC15603 structure
    GC15603JIB-04
    CAS: 199596-05-9
    纯度: >98.00%

    JIB-04是一种泛选择性Jumonji组蛋白去甲基化酶抑制剂，对JARID1A、JMJD2E、JMJD3、JMJD2A、JMJD2B、JMJD2C和JMJD2D的IC 50 值分别为230nM、340nM、855nM、445nM、435nM、1100nM和290nM。

  • GC15652 structure
    GC15652UNC 2400
    CAS: 1433200-49-7

    UNC 2400 与 UNC1999 非常相似，作为细胞研究的阴性对照，其效力比 UNC1999 低 1,000 倍以上。

  • GC15688 structure
    GC15688UNC 0224
    CAS: 1197196-48-7
    纯度: >99.00% / >98.00%

    A potent inhibitor of G9a histone methyltransferase

  • GC15711 structure
    GC15711Aurora Kinase Inhibitor III
    CAS: 879127-16-9
    纯度: >99.00%

    A potent inhibitor of Aurora A kinase

  • GC15731 structure
    GC15731L002
    CAS: 321695-57-2
    纯度: >98.50%

    A p300 acetyltransferase inhibitor

  • GC15747 structure
    GC15747I-BET151 (GSK1210151A)
    CAS: 1300031-49-5
    纯度: >99.50%

    A BRD2, BRD3, and BRD4 inhibitor

  • GC15783 structure
    GC15783GSK126
    CAS: 1346574-57-9
    纯度: >98.00%

    GSK126(GSK2816126A, GSK2816126)是一种高选择性EZH2甲基转移酶抑制剂，在体外的IC 50 为12.6~17.4nM；在体内的IC 50 为9.9nM。

  • GC15789 structure
    GC15789GSK2801
    CAS: 1619994-68-1
    纯度: >99.50%

    A probe for BAZ2A/B bromodomains

  • GC15804 structure
    GC15804PTP Inhibitor II
    CAS: 2632-13-5
    纯度: >98.00%

    A SHP-1(ΔSH2) inhibitor

  • GC15830 structure
    GC15830Daminozide
    CAS: 1596-84-5
    纯度: >98.00%

    Selective inhibitor of KDM2/7 histone demethylases

  • GC15836 structure
    GC15836IWP 12
    CAS: 688353-45-9

    A PORCN inhibitor

  • GC15857 structure
    GC15857Sodium butyrate
    CAS: 156-54-7
    纯度: >99.00%

    A short-chain fatty acid and HDAC inhibitor

  • GC15931 structure
    GC15931AGK7
    CAS: 304896-21-7

    An inactive control for AGK2

  • GC15969 structure
    GC15969PTP Inhibitor IV
    CAS: 329317-98-8

    An active-site directed inhibitor of protein tyrosine phosphatases

  • GC15974 structure
    GC15974bpV(HOpic) (potassium salt, technical grade)
    CAS: 722494-26-0
    纯度: >95.00%

    A PTEN inhibitor