GlpBio

Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

研究方向

Chromatin/Epigenetics 相关产品(1617)

  • GC16015 structure
    GC16015A 366
    CAS: 1527503-11-2
    纯度: >98.00% / >97.00%

    A 366是一种选择性的G9a/GLP组蛋白甲基转移酶抑制剂，可抑制G9a（IC 50 =3.3nM）和GLP（IC 50 =38nM）的活性。

  • GC16114 structure
    GC16114Bizine
    CAS: 1591932-50-1
    纯度: >95.00%

    An LSD1 inhibitor

  • GC16130 structure
    GC16130C 21
    CAS: 1229236-78-5

    Protein arginine methyltransferase 1 (PRMT1) inhibitor

  • GC16224 structure
    GC16224EPZ031686
    CAS: 1808011-22-4
    纯度: >99.50%

    EPZ031686是一种有效且具有口服活性的SMYD3抑制剂，其IC 50 值为3nM，EPZ031686能够以非竞争性方式同时抑制SAM和MEKK2，其Ki值分别约为1.2nM和1.1nM。

  • GC16261 structure
    GC16261LLY507
    CAS: 1793053-37-8
    纯度: >98.00%

    A SMYD2 inhibitor

  • GC16277 structure
    GC16277α-Amanitin
    CAS: 23109-05-9
    纯度: >95.00% / >90.00%

    A selective RNA polymerase II inhibitor

  • GC16298 structure
    GC16298CPI-1205
    CAS: 1621862-70-1

    EZH2抑制剂

  • GC16299 structure
    GC16299BET bromodomain inhibitor
    CAS: 1380087-89-7
    纯度: >99.50%

    BET 溴结构域抑制剂是从专利 WO/2015/153871A2 化合物实施例 11 中提取的一种有效的 BET 抑制剂。

  • GC16314 structure
    GC16314TC-E 5001
    CAS: 865565-29-3

    TC-E 5001 是一种 Wnt 通路抑制剂，通过新的腺苷口袋结合抑制 tankyrase 1/2 (TNKS1/2)，Kd 分别为 79 nM 和 28 nM。 TC-E 5001 还抑制 Axin2 和 STF，IC50 分别为 0.709 μM 和 0.215 μM。

  • GC16378 structure
    GC16378TC-A 2317 hydrochloride
    CAS: 1245907-03-2

    TC-A 2317 hydrochloride 是一种具有口服活性的 Aurora A 激酶抑制剂 (Ki=1.2 nM)。 TC-A 2317 hydrochloride 对 Aurora B 激酶 (Ki=101 nM) 和其他 60 种激酶具有出色的选择性、良好的细胞渗透性和良好的 PK 曲线。抗肿瘤活性。

  • GC16397 structure
    GC16397OICR-9429
    CAS: 1801787-56-3
    纯度: >99.50%

    OICR-9429是一种有效的高亲和力的WD repeat domain 5（WDR5）抑制剂，与WDR5结合的K d 值为93±28nM。

  • GC16432 structure
    GC16432MS023 (hydrochloride)
    CAS: 2108631-19-0

    An inhibitor of type I PRMTs

  • GC16436 structure
    GC16436Tenovin-6
    CAS: 1011557-82-6
    纯度: >98.50%

    A small molecule activator of p53

  • GC16509 structure
    GC16509Adox
    CAS: 34240-05-6
    纯度: >99.50% / >95.00%

    An irreversible inhibitor of SAH hydrolase

  • GC16519 structure
    GC16519ENMD-2076
    CAS: 934353-76-1
    纯度: >98.00%

    A multi-kinase inhibitor

  • GC16599 structure
    GC16599CPI-169
    CAS: 1450655-76-1
    纯度: >98.00%

    A selective EZH2 inhibitor

  • GC16611 structure
    GC16611GW841819X

    BET bromodomain inhibitor

  • GC16614 structure
    GC16614SCH-1473759
    CAS: 1094069-99-4

    SCH-1473759 是一种极光抑制剂，对极光 A 和 B 的 IC50 分别为 4 和 13 nM。

  • GC16638 structure
    GC16638FG2216
    CAS: 223387-75-5
    纯度: >99.00%

    An inhibitor of HIF-PH2

  • GC16647 structure
    GC16647Daprodustat(GSK1278863)
    CAS: 960539-70-2
    纯度: >98.00%

    A HIF-PH1, -2, and -3 inhibitor

  • GC16725 structure
    GC16725AZ6102
    CAS: 1645286-75-4
    纯度: >99.50%

    A TNKS1/2 inhibitor

  • GC16726 structure
    GC16726BI-7273
    CAS: 1883429-21-7
    纯度: >99.50%

    A potent BRD9 bromodomain inhibitor

  • GC16741 structure
    GC16741UNC0379
    CAS: 1620401-82-2
    纯度: >99.50%

    A selective SET8 inhibitor

  • GC16763 structure
    GC16763NI-57
    CAS: 1883548-89-7
    纯度: >99.50%

    A BRPF bromodomain inhibitor