Chromatin/Epigenetics
Chromatin/Epigenetics(染色质/表观遗传学)
Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
- Bromodomain(50)
- Aurora Kinase(63)
- DNA Methyltransferase(35)
- HDAC(210)
- Histone Acetyltransferases(78)
- Histone Demethylases(110)
- Histone Methyltransferase(240)
- HIF(102)
- JAK(173)
- MBT Domains(1)
- PARP(122)
- Pim(32)
- Protein Ser/Thr Phosphatases(34)
- RNA Polymerase(7)
- Sirtuin(77)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(21)
- Epigenetic Reader Domain(246)
- MicroRNA(24)
- Protein Arginine Deiminase(7)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(44)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(1)
- METTL3(2)
- WDR5(1)
- TET Protein(2)
- HuR(1)
- SF3B1(1)
Chromatin/Epigenetics 相关产品(1617)
- GC16900PRL-3 InhibitorCAS: 893449-38-2纯度: >98.50%
PRL-3 Inhibitor是一种针对再生肝磷酸酶-3（PRL-3）的抑制剂，其半数抑制浓度（IC 50 ）为0.9μM。
- GC17126EX-527 R-enantiomerCAS: 848193-69-1纯度: >98.50%
EX-527 R-对映异构体 ((R)-EX-527) 是 Selisstat 的 R-对映异构体。 Selisistat (EX-527) 是一种有效的选择性 SIRT1 抑制剂，IC50 为 98 nM。
- GC17222GLPG0634 analogueCAS: 1206101-20-3纯度: >98.50%
GLPG0634 类似物 (Compoun 176) 是一种广谱 JAK 抑制剂，对 JAK1、JAK2 和 JAK3 的 IC50 值 <100 nM。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC16794 | UNC1215 | 1415800-43-9 | >98.00% | |
Potent L3MBTL3 domain inhibitor | ||||
| GC16811 | Vadadustat | 1000025-07-9 | >98.00% | |
An inhibitor of HIF-PH2 and HIF-PH3 | ||||
| GC16817 | BI-9564 | 1883429-22-8 | >99.50% | |
A selective BRD9/7 bromodomain inhibitor | ||||
| GC16875 | FLLL32 | 1226895-15-3 | >99.50% | |
An inhibitor of JAK2/STAT3 signaling | ||||
| GC16900 | PRL-3 Inhibitor | 893449-38-2 | >98.50% | |
PRL-3 Inhibitor是一种针对再生肝磷酸酶-3（PRL-3）的抑制剂，其半数抑制浓度（IC 50 ）为0.9μM。 | ||||
| GC16914 | MN 64 | 92831-11-3 | >99.50% | |
A TNKS inhibitor | ||||
| GC16973 | DMOG | 89464-63-1 | >98.50% / >98.00% | |
DMOG（二羟基丙氨酸）是 α-酮戊二酸辅助因子的拮抗剂和 HIF-脯氨酸羟化酶的抑制剂，导致 HIF-1α 蛋白在细胞核中的稳定和积累。 | ||||
| GC17005 | 4-iodo-SAHA | 1219807-87-0 | - | |
A potent SAHA analog | ||||
| GC17023 | HLCL-61 | 1158279-20-9 | >99.50% | |
A PRMT5 inhibitor | ||||
| GC17073 | I-BET-762 | 1260907-17-2 | >99.00% | |
Inhibitor of BET proteins | ||||
| GC17118 | GSK J5 | 1394854-51-3 | >95.00% | |
A negative control compound for GSK-J4 | ||||
| GC17126 | EX-527 R-enantiomer | 848193-69-1 | >98.50% | |
EX-527 R-对映异构体 ((R)-EX-527) 是 Selisstat 的 R-对映异构体。 Selisistat (EX-527) 是一种有效的选择性 SIRT1 抑制剂，IC50 为 98 nM。 | ||||
| GC17196 | Hesperadin | 422513-13-1 | >98.00% | |
Hesperadin是一种竞争性ATP结合抑制剂，对Aurora B激酶的IC 50 为250nM。 | ||||
| GC17207 | UNC3866 | 1872382-47-2 | >98.00% | |
An inhibitor of CBX7 | ||||
| GC17222 | GLPG0634 analogue | 1206101-20-3 | >98.50% | |
GLPG0634 类似物 (Compoun 176) 是一种广谱 JAK 抑制剂，对 JAK1、JAK2 和 JAK3 的 IC50 值 <100 nM。 | ||||
| GC17275 | AMI-1 | 20324-87-2 | >98.00% | |
A cell permeable inhibitor of PRMTs | ||||
| GC17284 | Anacardic acid | 16611-84-0 | >98.00% | |
A histone acetyltransferase inhibitor | ||||
| GC17428 | SGI-110 | 929901-49-5 | - | |
SGI-110 (SGI-110) 是第二代 DNA 甲基转移酶 (DNMT) 抑制剂，用于研究急性髓性白血病 (AML) 和骨髓增生异常综合征 (MDS)。 | ||||
| GC17455 | TAK-632 | 1228591-30-7 | >98.00% | |
A selective pan-Raf inhibitor | ||||
| GC17472 | Oxamflatin | 151720-43-3 | >98.00% | |
Inhibitor of histone deacetylases | ||||
| GC17482 | OF-1 | 919973-83-4 | >98.00% | |
A bromodomain probe for BRPF proteins | ||||
| GC17534 | GSK343 | 1346704-33-3 | >98.00% | |
A selective, cell-permeable EZH2 inhibitor | ||||
| GC17546 | AMI5 | 17372-87-1 | - | |
曙红 Y（二钠）是一种可溶性酸性红色染料分子。 | ||||
| GC17555 | NVP-TNKS656 | 1419949-20-4 | >98.00% | |
A TNKS2 inhibitor | ||||