PRL-3 Inhibitor

目录号: GC16900纯度: >98.50%同义词: BR-1,P0108,Phosphatase of Regenerating Liver 3 Inhibitor,PTP4A3 Inhibitor

PRL-3 Inhibitor是一种针对再生肝磷酸酶-3（PRL-3）的抑制剂，其半数抑制浓度（IC₅₀）为0.9μM。

Cas No.: 893449-38-2

规格	价格	库存	数量
1mg	¥185.00	现货	1
5mg	¥462.00	现货	1
10mg	¥770.00	现货	1
25mg	¥1,540.00	现货	1
50mg	¥2,310.00	现货	1
100mg	¥3,465.00	现货	1
10mM (in 1mL DMSO)	¥508.00	现货	1

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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例

Nature
641, 529–536 (2025)
Nature
628, 630–638 (2024)
Nature
632, 686–694 (2024)
Nature
618, 1017–1023 (2023)
Nature
610, 366–372 (2022)
Cell
187(9):2288-2304 (2024)
Cell
183(7):1867-1883 (2020)
Science
388(6745) (2025)
Science
387(6739) (2025)
Science
387(6734) (2025)
Cell Research
35, 97–116 (2025)
Cell Research
34, 683–706 (2024)
Cell Research
33, 273–287 (2023)
Cell Research
33, 546–561 (2023)
Cell Research
33, 904–922 (2023)
Cell Research
31, 1291–1307 (2021)

产品描述 Description

The PRL-3 Inhibitor is an inhibitor of phosphatase of regenerating liver-3 (PRL-3) with an IC₅₀ of 0.9μM^[1].

In vitro, PRL-3 Inhibitor (compound 5e) (0, 1, 10, and 30μg/mL; 22h) inhibits the invasion of mouse melanoma B16F10 cells^[1].

References:
[1] Ahn JH, Kim SJ, Park WS, et al. Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2996-9.

PRL-3 Inhibitor是一种针对再生肝磷酸酶-3（PRL-3）的抑制剂，其半数抑制浓度（IC₅₀）为0.9μM^[1]。

在体外实验中，PRL-3 Inhibitor（compound 5e）（0, 1, 10和30μg/mL; 22小时）能够抑制小鼠黑色素瘤B16F10细胞的侵袭^[1]。

实验参考方法 Experimental Reference Method

Cell experiment [1]:
Cell lines	B16F10 cells
Preparation Method	A total of 1×10⁵ B16F10 cells were seeded in the upper chamber of 24-well invasion chambers with 8μm polycarbonate filters, while the lower chamber contained conditioned medium from HT1080 cells as a chemoattractant. The cells were incubated for 22h at 37℃ in a humidified incubator with 5% CO₂ in the presence and absence of PRL-3 Inhibitor (0, 1, 10, and 30μg/mL). Non-migratory cells on the upper surface of the filter were removed by wiping with a cotton swab. Migrated cells on the underside of the membrane were stained with 0.5% crystal violet after fixation with methanol and observed under a microscope.
Reaction Conditions	0, 1, 10, and 30μg/mL; 22h
Applications	PRL-3 Inhibitor (compound 5e) inhibits the invasion of mouse melanoma B16F10 cells.
References: [1] Ahn JH, Kim SJ, Park WS, et al. Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2996-9.

产品文档 Product Documents

Purity:>98.50%Appearance:A solid

化学性质Chemical Properties

CAS 号

893449-38-2

同义词

BR-1,P0108,Phosphatase of Regenerating Liver 3 Inhibitor,PTP4A3 Inhibitor

化学名

5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone

SMILES

BrC1=CC=C(OCC2=C(Br)C=CC=C2)C(/C=C3C(NC(S\3)=S)=O)=C1

分子式

C₁₇H₁₁Br₂NO₂S₂

分子量

485.2 g/mol

溶解性

≤16mg/ml in DMSO;16mg/ml in dimethyl formamide

保存条件

4°C, protect from light

General tips

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。

Shipping Condition

评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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