2-Hydroxyanthraquinone is an anthraquinone that has been found in Spermacoce latifolia and has antibacterial and estrogenic activities.1,2 It is active against B. subtilis and B. cereus (MICs = 1.9 and 62.5 µg/ml, respectively).1 2-Hydroxyanthraquinone (19 µM) induces estrogen receptor α (ERα) activation in a yeast two-hybrid assay.2
1.Luo, Y., Shen, H.-Y., Shen, Q.-X., et al.A new anthraquinone and a new naphthoquinone from the whole plant of Spermacoce latifoliJ. Asian Nat. Prod. Res.19(9)869-876(2017) 2.Kurihara, R., Shiraishi, F., Tanaka, N., et al.Presence and estrogenicity of anthracene derivatives in coastal Japanese watersEnviron. Toxicol. Chem.24(8)1984-1993(2005)