Chromatin/Epigenetics
Chromatin/Epigenetics(染色质/表观遗传学)
Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
- Bromodomain(50)
- Aurora Kinase(63)
- DNA Methyltransferase(35)
- HDAC(210)
- Histone Acetyltransferases(78)
- Histone Demethylases(110)
- Histone Methyltransferase(240)
- HIF(102)
- JAK(173)
- MBT Domains(1)
- PARP(122)
- Pim(32)
- Protein Ser/Thr Phosphatases(34)
- RNA Polymerase(7)
- Sirtuin(77)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(21)
- Epigenetic Reader Domain(246)
- MicroRNA(24)
- Protein Arginine Deiminase(7)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(44)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(1)
- METTL3(2)
- WDR5(1)
- TET Protein(2)
- HuR(1)
- SF3B1(1)
Chromatin/Epigenetics 相关产品(1617)
- GC17704Triacetyl ResveratrolCAS: 42206-94-0纯度: >98.00%
A resveratrol derivative with diverse biological activities
- GC17973OTX-015CAS: 202590-98-5纯度: >99.50%
OTX-015 以浓度依赖性方式抑制 BRD2、BRD3 和 BRD4 与乙酰化组蛋白 4 的结合，IC50 值为 92-112nM .OTX-015 在九个 AML 细胞系中的六个和所有四个 ALL 细胞系中测量到显着的生长抑制:HEL IC50 值为 248 nM，NB4 IC50值为 233 nM，NOMO-1 IC50 值为 229 nM，KG1 IC50 值为 198 nM，OCI-AML3 IC50 值为Kasumi IC50 值为 60 nM，Kasumi IC50 值为 17 nM，JURKAT IC50 值为 249 nM，BV-173 IC50 值为 161 nM , TOM-1 IC50 值为 133 nM, RS4-11 IC50 值为 34 nM。
- GC18074PF-03814735CAS: 942487-16-3纯度: >99.00%
PF-03814735 是一种有效的、具有口服生物利用度的 Aurora1 和 Aurora2 激酶的可逆抑制剂，IC50 值分别为 0.8nM 和 5nM 。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC17672 | TC-E 5003 | 17328-16-4 | >95.00% | |
A PRMT1 inhibitor | ||||
| GC17703 | TMP269 | 1314890-29-3 | >98.00% | |
A selective class IIa HDAC inhibitor | ||||
| GC17704 | Triacetyl Resveratrol | 42206-94-0 | >98.00% | |
A resveratrol derivative with diverse biological activities | ||||
| GC17724 | Thiomyristoyl | 1429749-41-6 | >98.50% | |
Thiomyristoyl是一种高效且特异性的SIRT2抑制剂（IC 50 = 28 nM）。 | ||||
| GC17754 | IOX 1 | 5852-78-8 | >99.00% | |
A 2-oxoglutarate oxygenase inhibitor | ||||
| GC17762 | NSC 33994 | 82058-16-0 | - | |
NSC 33994 (G6) 是一种选择性 JAK2 抑制剂，IC50 为 60 nM。 | ||||
| GC17820 | AS8351 | 796-42-9 | >99.50% | |
A histone demethylase inhibitor | ||||
| GC17828 | BI-847325 | 1207293-36-4 | >99.00% | |
A selective dual MEK/Aurora kinase inhibitor | ||||
| GC17922 | 4'-bromo-Resveratrol | 1224713-90-9 | - | |
A potent inhibitor of SIRT1 and SIRT3 | ||||
| GC17956 | PFI-2 | 1627676-59-8 | - | |
PFI-2 ((R)-PFI-2 hydrochloride) hydrochloride 是一种有效的选择性 SET 结构域，含有赖氨酸甲基转移酶 7 (SETD7) 抑制剂。 | ||||
| GC17973 | OTX-015 | 202590-98-5 | >99.50% | |
OTX-015 以浓度依赖性方式抑制 BRD2、BRD3 和 BRD4 与乙酰化组蛋白 4 的结合，IC50 值为 92-112nM .OTX-015 在九个 AML 细胞系中的六个和所有四个 ALL 细胞系中测量到显着的生长抑制:HEL IC50 值为 248 nM，NB4 IC50值为 233 nM，NOMO-1 IC50 值为 229 nM，KG1 IC50 值为 198 nM，OCI-AML3 IC50 值为Kasumi IC50 值为 60 nM，Kasumi IC50 值为 17 nM，JURKAT IC50 值为 249 nM，BV-173 IC50 值为 161 nM , TOM-1 IC50 值为 133 nM, RS4-11 IC50 值为 34 nM。 | ||||
| GC18074 | PF-03814735 | 942487-16-3 | >99.00% | |
PF-03814735 是一种有效的、具有口服生物利用度的 Aurora1 和 Aurora2 激酶的可逆抑制剂，IC50 值分别为 0.8nM 和 5nM 。 | ||||
| GC18096 | UNC669 | 1314241-44-5 | >98.50% | |
A selective MBT inhibitor | ||||
| GC18161 | BCI-121 | 432529-82-3 | >99.00% | |
An inhibitor of SMYD3 | ||||
| GC18172 | E7449 | 1140964-99-3 | >98.00% | |
An inhibitor of PARP1, PARP2, and TNKS1/2 | ||||
| GC18206 | WT161 | 1206731-57-8 | >98.50% | |
A potent inhibitor of HDAC6 | ||||
| GC18228 | CAY10602 | 374922-43-7 | >98.50% | |
A SIRT1 activator | ||||
| GC18236 | Echinomycin | 512-64-1 | >95.00% | |
An inhibitor of HIF-1-mediated gene transcription | ||||
| GC18402 | GSK3117391 | 1018673-42-1 | >98.50% | |
An HDAC inhibitor | ||||
| GC18408 | BML-278 | 120533-76-8 | - | |
An activator of SIRT1, SIRT2, and SIRT3 | ||||
| GC18428 | SGC2085 (hydrochloride) | 1821908-49-9 | - | |
A PRMT4/CARM1 inhibitor | ||||
| GC18508 | BAY-299 | 2080306-23-4 | >99.00% | |
A potent and selective BRD1 inhibitor | ||||
| GC18509 | 3-Methylcytidine (methosulfate) | 21028-20-6 | >95.00% | |
An internal standard for HPLC | ||||
| GC18577 | CID-2818500 | 1215-07-2 | - | |
An inhibitor of PRMT1 | ||||