GlpBio

Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

研究方向

Chromatin/Epigenetics 相关产品(1617)

  • GC18623 structure
    GC18623α-Hydroxyglutaric Acid
    CAS: 2889-31-8
    纯度: >98.00%

    An α-hydroxy acid

  • GC18642 structure
    GC18642SW155246
    CAS: 420092-79-1

    A DNA methyltransferase 1 inhibitor

  • GC18650 structure
    GC18650S-(5'-Adenosyl)-L-methionine (tosylate)
    CAS: 52248-03-0
    纯度: >98.00%

    S-Adenosyl-L-methioninetosylate(S-Adenosylmethioninetosylate)是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和ATP内源性生产的，是一种重要的具有口服活性的甲基供体。

  • GC18729 structure
    GC18729MZ1
    CAS: 1797406-69-9
    纯度: >99.00%

    A PROTAC that drives BRD4 degradation

  • GC18731 structure
    GC18731LP99
    CAS: 1808951-93-0
    纯度: >98.50% / >99.50%

    A selective inhibitor of BRD7/9

  • GC18750 structure
    GC18750NEO2734
    CAS: 2081072-29-7
    纯度: >99.50%

    NEO2734 (EP31670) 是一种口服有效的双重 p300/CBP 和 BET 溴结构域选择性抑制剂，对 p300/CBP 和 BET 溴结构域的 IC50 值均 <30 nM。 NEO2734 在 SPOP 突变型和野生型前列腺癌中具有活性。

  • GC18915 structure
    GC18915Trapoxin A
    CAS: 133155-89-2

    Trapoxin A is a cyclotetrapeptide histone deacetylase (HDAC) inhibitor.

  • GC18949 structure
    GC18949CAY10677
    CAS: 1443253-20-0

    An inhibitor of protein prenylation

  • GC19013 structure
    GC190133-TYP
    CAS: 120241-79-4
    纯度: >99.50% / >98.00%

    3-TYP 抑制 SIRT3，IC50 为 16 nM，比 SIRT1 和 SIRT2 更有效，IC50 分别为 88 nM 和 92 nM。

  • GC19020 structure
    GC19020ACY-738
    CAS: 1375465-91-0
    纯度: >98.50%

    ACY-738是一种具有口服活性的选择性组蛋白去乙酰化酶6（HDAC6；IC 50 =1.7nM）抑制剂。

  • GC19038 structure
    GC19038ARV-825
    CAS: 1818885-28-7
    纯度: >99.00%

    A BRD4 inhibitor that drives BRD4 degradation

  • GC19092 structure
    GC19092CCT241736
    CAS: 1402709-93-6
    纯度: >98.00%

    A dual inhibitor of Aurora kinases and FLT3

  • GC19098 structure
    GC19098CeMMEC1
    CAS: 440662-09-9
    纯度: >99.50%

    A selective TAF1 bromodomain 2 inhibitor

  • GC19119 structure
    GC19119dBET1
    CAS: 1799711-21-9
    纯度: >98.00%

    A hybrid molecule containing (+)-JQ-1 and thalidomide

  • GC19129 structure
    GC19129EDO-S101
    CAS: 1236199-60-2
    纯度: >98.00%

    An HDAC inhibitor and DNA alkylating agent

  • GC19130 structure
    GC19130EED226
    CAS: 2083627-02-3
    纯度: >98.50%

    EED226是一种强效的多梳抑制复合物2（PRC2）抑制剂，IC 50 值为22.3nM。

  • GC19141 structure
    GC19141EPZ011989
    CAS: 1598383-40-4
    纯度: >99.50%

    An orally bioavailable EZH2 inhibitor

  • GC19149 structure
    GC19149EZM 2302
    CAS: 1628830-21-6
    纯度: >99.00%

    EZM 2302是一种对CARM1有效的且具有选择性的抑制剂，其IC 50 值为6nM。

  • GC19181 structure
    GC19181GSK2807 Trifluoroacetate
    CAS: 2245255-66-5

    GSK2807 Trifluoroacetate 是一种有效的、选择性的、SAM 竞争性的 SMYD3 抑制剂，Ki 为 14 nM，IC50 为 130 nM。

  • GC19189 structure
    GC19189HDAC8-IN-1
    CAS: 1417997-93-3
    纯度: >99.50%

    An HDAC8 inhibitor

  • GC19190 structure
    GC19190HDAC-IN-4
    CAS: 934828-12-3
    纯度: >99.00% / >99.50%

    An HDAC inhibitor

  • GC19200 structure
    GC19200INCB-057643
    CAS: 1820889-23-3
    纯度: >98.00%

    A BET family protein inhibitor

  • GC19204 structure
    GC19204Itacitinib
    CAS: 1334298-90-6
    纯度: >99.50%

    Itacitinib是一种JAK1抑制剂（IC 50 =2nM），Itacitinib可通过选择性抑制JAK1酪氨酸激酶以调节JAK-STAT信号通路，同时通过减少促炎细胞因子的产生以调控免疫反应。

  • GC19210 structure
    GC19210JQ-1 carboxylic acid
    CAS: 202592-23-2
    纯度: >99.00%

    A selective inhibitor of BET bromodomains