GlpBio

Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

研究方向

Chromatin/Epigenetics 相关产品(1617)

  • GC19211 structure
    GC19211JQEZ5
    CAS: 1913252-04-6
    纯度: >98.00%

    An EZH2 inhibitor

  • GC19246 structure
    GC19246MI-463
    CAS: 1628317-18-9
    纯度: >99.50%

    An inhibitor of menin-MLL fusion protein interactions

  • GC19247 structure
    GC19247MI-503
    CAS: 1857417-13-0
    纯度: >99.50%

    MI-503 是一种高效且具有口服生物利用度的 menin-mLL 相互作用的小分子抑制剂。

  • GC19248 structure
    GC19248Mivebresib
    CAS: 1445993-26-9
    纯度: >99.00%

    A BRD2, BRD4, and BRDT inhibitor

  • GC19251 structure
    GC19251MK-8617
    CAS: 1187990-87-9
    纯度: >98.00%

    A HIF-PH1, -2, and -3 inhibitor

  • GC19264 structure
    GC19264NMS-P118
    CAS: 1262417-51-5
    纯度: >99.50%

    A potent and selective PARP1 inhibitor

  • GC19288 structure
    GC19288PF-06651600
    CAS: 1792180-81-4
    纯度: >99.50%

    PF-06651600 (PF-06651600) 是一种具有口服活性的选择性 JAK3 抑制剂，IC50 为 33.1 nM。

  • GC19298 structure
    GC19298PLX51107
    CAS: 1627929-55-8
    纯度: >99.50%

    A BET family protein inhibitor

  • GC19320 structure
    GC19320SAR-20347
    CAS: 1450881-55-6
    纯度: >98.00%

    A JAK family kinase inhibitor

  • GC19328 structure
    GC19328SF2523
    CAS: 1174428-47-7

    A dual inhibitor of PI3K and BRD4

  • GC19329 structure
    GC19329SGC2085
    CAS: 1821908-48-8
    纯度: >99.50%

    A PRMT4/CARM1 inhibitor

  • GC19334 structure
    GC19334Solcitinib
    CAS: 1206163-45-2
    纯度: >99.50%

    A JAK1 inhibitor

  • GC19337 structure
    GC19337SR-4370
    CAS: 1816294-67-3
    纯度: >98.00%

    An HDAC3 inhibitor

  • GC19360 structure
    GC19360TMP195
    CAS: 1314891-22-9
    纯度: >99.50%

    TMP195 是一种有效的选择性 IIa 类 HDAC 抑制剂，对 HDAC4、HDAC5、HDAC7 和 HDAC9 的 IC50 分别为 59 nM、60 nM、26 nM 和 15 nM。

  • GC19361 structure
    GC19361TP-3654
    CAS: 1361951-15-6
    纯度: >99.50%

    A Pim kinase inhibitor

  • GC19368 structure
    GC19368Upadacitinib
    CAS: 1310726-60-3
    纯度: >99.50% / >98.00%

    Upadacitinib是一种高效、口服并可逆的选择性 Janus激酶 1 (JAK1) 抑制剂，IC 50 值为0.043μM 。

  • GC19388 structure
    GC19388XY1
    CAS: 1624117-53-8
    纯度: >99.00%

    A negative control for SGC707

  • GC19398 structure
    GC19398PIM447
    CAS: 1210608-43-7

    PIM447 (LGH447) 是一种有效的、口服的、选择性的泛 PIM 激酶抑制剂，对 PIM1、PIM2 和 PIM3 的 Ki 值分别为 6、18 和 9 pM。 PIM447 具有双重抗骨髓瘤和骨保护作用。 PIM447 诱导细胞凋亡。

  • GC19405 structure
    GC19405PF-06700841 P-Tosylate
    CAS: 2140301-96-6
    纯度: >99.50%

    PF-06700841 P-Tosylate是一种强效的双重Janus激酶1（JAK1）和TYK2抑制剂，IC 50 值分别为17nM和23nM。

  • GC19406 structure
    GC19406TH34
    CAS: 2196203-96-8
    纯度: >98.00%

    TH34 是一种 HDAC6/8/10 抑制剂，IC50 分别为 4.6 μM、1.9 μM 和 7.7 μM，对 HDAC1/2/3 具有高选择性。

  • GC19408 structure
    GC19408FM381
    CAS: 2226521-65-7
    纯度: >98.00%

    A potent JAK3 inhibitor

  • GC19409 structure
    GC19409ABBV-744
    CAS: 2138861-99-9
    纯度: >99.50%

    A BD2 bromodomain inhibitor

  • GC19410 structure
    GC19410NCGC00244536
    CAS: 2003260-55-5
    纯度: >98.00%

    A KDM4B/JMJD2B inhibitor

  • GC19419 structure
    GC19419PIM inhibitor 1 phosphate
    CAS: 2088852-47-3
    纯度: >98.00%

    Uzansertib (INCB053914) phosphate 是一种具有口服活性的 ATP 竞争性泛 PIM 激酶抑制剂，对 PIM1、PIM2、PIM3 的 IC50 分别为 0.24 nM、30 nM、0.12 nM。 PIM inhibitor 1 phosphate 对多种血液肿瘤细胞系具有广泛的抗增殖活性。