Chromatin/Epigenetics
Chromatin/Epigenetics(染色质/表观遗传学)
Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
- Bromodomain(50)
- Aurora Kinase(63)
- DNA Methyltransferase(35)
- HDAC(210)
- Histone Acetyltransferases(78)
- Histone Demethylases(110)
- Histone Methyltransferase(240)
- HIF(102)
- JAK(173)
- MBT Domains(1)
- PARP(122)
- Pim(32)
- Protein Ser/Thr Phosphatases(34)
- RNA Polymerase(7)
- Sirtuin(77)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(21)
- Epigenetic Reader Domain(246)
- MicroRNA(24)
- Protein Arginine Deiminase(7)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(44)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(1)
- METTL3(2)
- WDR5(1)
- TET Protein(2)
- HuR(1)
- SF3B1(1)
Chromatin/Epigenetics 相关产品(1617)
- GC25139Biphenyl-4-sulfonyl chlorideCAS: 1623-93-4
Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation.
- GC25168Brepocitinib (PF-06700841)CAS: 1883299-62-4
Brepocitinib (PF-06700841, PF-841) is a potent inhibitor of Tyk2 and Jak1 with IC50s of 23 nM, 17 nM, 77 nM for Tyk2, Jak1 and Jak2 respectively. It has appropriate in-family selectivity against JAK2 and JAK3.
- GC25305CPI-455 HClCAS: 2095432-28-1
CPI-455 HCl is a specific KDM5 inhibitor with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
- GC25483GSK3368715 (EPZ019997) 3HClCAS: 2227587-26-8
GSK3368715 is a potent inhibitor of type I protein arginine methyltransferases (PRMT) that inhibits PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM.
- GC26265α-Hydroxyglutaric acid disodiumCAS: 40951-21-1纯度: ≥98.00%
α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium 是戊二酸的 α-羟基酸形式。
- GC30251SIRT5 inhibitorCAS: 2166487-21-2纯度: >98.00%
SIRT5 inhibitor 是一种有效的 Human Sirtuin 5 deacylase 抑制剂，IC50 为 0.11 μM.
- GC30263Glucosamine (D-Glucosamine)CAS: 3416-24-8纯度: >98.00%
Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.
- GC30501Lin28-let-7a antagonist 1CAS: 2024548-03-4纯度: >99.50%
Lin28-let-7aantagonist1对Lin28-let-7a的结合有明显的拮抗作用，其对Lin28A-let-7a-1结合的IC50值为4.03μM。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC19455 | ZL0420 | 2230496-80-5 | >98.00% | |
A BRD4 inhibitor | ||||
| GC19465 | JNJ-64619178 | 2086772-26-9 | >99.50% | |
A PRMT5 inhibitor | ||||
| GC19505 | RK-287107 | 2171386-10-8 | >99.50% | |
A TNKS1/2 inhibitor | ||||
| GC19542 | GeA-69 | 2143475-98-1 | >99.50% | |
GeA-69 是一种多聚腺苷二磷酸核糖聚合酶 14 (PARP14) 的选择性变构抑制剂，靶向大结构域 2 (MD2)，Kd 值为 2.1 µM。 GeA-69 参与 DNA 损伤修复机制并阻止 PARP14 MD2 募集到激光诱导的 DNA 损伤部位。 | ||||
| GC19747 | CX-6258 HCl | 1353859-00-3 | >99.00% | |
A pan-Pim kinase inhibitor | ||||
| GC19849 | SGC3027 | 2624313-13-7 | >98.50% / >98.00% | |
A prodrug form of SGC8158 | ||||
| GC19891 | CTB | 451491-47-7 | >98.00% / >99.00% | |
CTB 是一种有效的 p300 组蛋白乙酰转移酶激活剂 。 | ||||
| GC19936 | Quisinostat dihydrochloride | 875320-31-3 | - | |
A pan-HDAC inhibitor | ||||
| GC25139 | Biphenyl-4-sulfonyl chloride | 1623-93-4 | - | |
Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation. | ||||
| GC25159 | BMF-219 | 2448172-22-1 | >98.00% | |
BMF-219是一种高选择性和不可逆的menin抑制剂,在小鼠模型中具有良好的抑制效果 。 | ||||
| GC25168 | Brepocitinib (PF-06700841) | 1883299-62-4 | - | |
Brepocitinib (PF-06700841, PF-841) is a potent inhibitor of Tyk2 and Jak1 with IC50s of 23 nM, 17 nM, 77 nM for Tyk2, Jak1 and Jak2 respectively. It has appropriate in-family selectivity against JAK2 and JAK3. | ||||
| GC25304 | CP2 | no CAS | - | |
CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively. | ||||
| GC25305 | CPI-455 HCl | 2095432-28-1 | - | |
CPI-455 HCl is a specific KDM5 inhibitor with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents.This product has poor solubility, animal experiments are available, cell experiments please choose carefully! | ||||
| GC25483 | GSK3368715 (EPZ019997) 3HCl | 2227587-26-8 | - | |
GSK3368715 is a potent inhibitor of type I protein arginine methyltransferases (PRMT) that inhibits PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM. | ||||
| GC25552 | KT-531 | 2490284-18-7 | - | |
KT-531 (KT531) is a potent, selective HDAC6 inhibitor with IC50 of 8.5 nM, displays 39-fold selectivity over other HDAC isoforms. | ||||
| GC25580 | LLY-284 | 2226515-75-7 | - | |
LLY-284 is the diastereomer of LLY-283, which is a potent and selective SAM-competitive chemical probe for PRMT5. LLY-284 is much less active than LLY-283 and can be used as a negative control for LLY-283. | ||||
| GC25869 | RO495 | 1258296-60-4 | - | |
RO495 (CS-2667) is a potent inhibitor of Non-receptor tyrosine-protein kinase 2 (TYK2). | ||||
| GC25940 | SNS-314 | 1057249-41-8 | - | |
SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1. | ||||
| GC25992 | TG-89 | 936091-56-4 | - | |
TG-89 is an inhibitor of JAK2 with IC50 of 11.2 μM. | ||||
| GC26265 | α-Hydroxyglutaric acid disodium | 40951-21-1 | ≥98.00% | |
α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium 是戊二酸的 α-羟基酸形式。 | ||||
| GC30204 | Sirtuin modulator 1 | 2070015-26-6 | >99.50% | |
A SIRT1 activator | ||||
| GC30251 | SIRT5 inhibitor | 2166487-21-2 | >98.00% | |
SIRT5 inhibitor 是一种有效的 Human Sirtuin 5 deacylase 抑制剂，IC50 为 0.11 μM. | ||||
| GC30263 | Glucosamine (D-Glucosamine) | 3416-24-8 | >98.00% | |
Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites. | ||||
| GC30501 | Lin28-let-7a antagonist 1 | 2024548-03-4 | >99.50% | |
Lin28-let-7aantagonist1对Lin28-let-7a的结合有明显的拮抗作用，其对Lin28A-let-7a-1结合的IC50值为4.03μM。 | ||||