GlpBio

Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

研究方向

Chromatin/Epigenetics 相关产品(1617)

  • GC30503 structure
    GC30503A-893
    CAS: 1868232-32-9

    A-893是一个有细胞活性的，SMYD2的抑制剂，其IC50值为2.8nM。

  • GC30526 structure
    GC30526ACY-957
    CAS: 1609389-52-7
    纯度: >99.50%

    ACY-957是一种选择性的HDAC1和HDAC2抑制剂，对HDAC1/2/3的IC50值分别为7nM，18nM和1300nM，对HDAC4/5/6/7/8/9无作用。

  • GC30530 structure
    GC30530Dot1L-IN-2
    CAS: 1940206-71-2

    Dot1L-IN-2是一种有效的，选择性的，可口服的Dot1L(一种histonemethyltransferase)，IC50值和Ki值分别为0.4nM和0.08nM。

  • GC30601 structure
    GC30601Propanamide
    CAS: 916742-11-5

    Propanamide 是一种从专利 WO2012122452A1 化合物 II 中提取的强效选择性 JAK 抑制剂，具有治疗皮肤疾病（如皮肤狼疮）的潜力。

  • GC30644 structure
    GC30644INCB054329 Racemate
    CAS: 1628607-62-4

    INCB054329Racemate是BET蛋白的抑制剂。

  • GC30693 structure
    GC30693SIRT-IN-2
    CAS: 1431411-66-3
    纯度: >98.50%

    SIRT-IN-2是SIRT1/2/3的有效抑制剂，其IC50值分别为4，1，7nM。

  • GC30714 structure
    GC30714GSK4028
    CAS: 2079886-19-2
    纯度: >98.50%

    GSK4028是GSK4027的对映体阴性对照，GSK4027是一种PCAF/GCN5溴结构域的化学探针，而GSK4028对应的pIC50值为4.9。

  • GC30733 structure
    GC30733SIRT-IN-1
    CAS: 1431411-60-7

    SIRT-IN-1是SIRT1/2/3的有效抑制剂，其IC50值分别为15，10，33μM。

  • GC30763 structure
    GC30763Benzenebutyric acid (4-Phenylbutyric acid)
    CAS: 1821-12-1
    纯度: >98.00% / >99.00%

    4-Phenylbutyric acid (4-PBA, Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models.

  • GC30766 structure
    GC30766Tranylcypromine hemisulfate (dl-Tranylcypromine hemisulfate)
    CAS: 13492-01-8
    纯度: >99.00%

    Tranylcypromine (Parnate) is an irreversible inhibitor of monoamine oxidase (MAO) with a rapid onset of activity.

  • GC30782 structure
    GC30782ACY-775
    CAS: 1375466-18-4
    纯度: >99.50%

    An HDAC6 inhibitor

  • GC30922 structure
    GC30922SIRT2 Inhibitor II (AK-1)
    CAS: 330461-64-8
    纯度: >99.50%

    A SIRT2 inhibitor

  • GC31099 structure
    GC31099YF-2
    CAS: 1311423-89-8
    纯度: >99.00%

    A HAT activator

  • GC31230 structure
    GC31230Dencichin (Dencichine)
    CAS: 5302-45-4
    纯度: >98.00%

    Dencichin是一种最初从三七中提取的非蛋白质氨基酸，可以抑制HIF-脯氨酰羟化酶2（PHD-2）的活性。

  • GC31245 structure
    GC31245EML 425
    CAS: 1675821-32-5
    纯度: >98.00%

    An inhibitor of p300 and CBP

  • GC31358 structure
    GC31358HIF-2α-IN-1
    CAS: 1799948-06-3
    纯度: >99.50%

    HIF-2α-IN-1是一种HIF-2α抑制剂,IC50值小于500nM。

  • GC31365 structure
    GC31365γ-Oryzanol
    CAS: 11042-64-1

    Gamma-oryzanol (GO), a nutriactive phytochemical naturally occurring in crude rice bran oil, is an antioxidant compound used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass. γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM).

  • GC31498 structure
    GC31498TP0463518
    CAS: 1558021-37-6
    纯度: >98.00%

    A pan HIF-PH inhibitor

  • GC31511 structure
    GC31511Sinapinic acid (Sinapic acid)
    CAS: 530-59-6
    纯度: >99.50%

    A phenylpropanoid hydroxycinnamic acid with diverse biological activities

  • GC31654 structure
    GC31654KG-501 (Naphthol AS-E phosphate)
    CAS: 18228-17-6
    纯度: >98.00%

    KG-501 (Naphthol AS-E phosphate) 是一种能够抑制cAMP反应元件结合蛋白（CREB）与CREB结合蛋白（CBP）相互作用的小分子化合物，其IC₅₀值为6.89μM。

  • GC31659 structure
    GC31659Tyk2-IN-4 (BMS-986165)
    CAS: 1609392-27-9
    纯度: >99.50%

    An allosteric inhibitor of TYK2

  • GC31660 structure
    GC31660Delgocitinib (JTE-052)
    CAS: 1263774-59-9
    纯度: >99.50%

    Delgocitinib (JTE-052) (JTE-052) 是一种特异性 JAK 抑制剂，对 JAK1、JAK2、JAK3 和 Tyk2 的 IC50 分别为 2.8、2.6、13 和 58 nM。

  • GC31668 structure
    GC31668TYK2-IN-2
    CAS: 2098466-94-3
    纯度: >99.50%

    TYK2-IN-2是TYK2的抑制剂，可用于炎症及自身免疫病的研究。

  • GC31677 structure
    GC31677Oclacitinib maleate (PF-03394197 maleate)
    CAS: 1640292-55-2
    纯度: >99.50%

    A JAK family kinase inhibitor