GlpBio

Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

研究方向

Chromatin/Epigenetics 相关产品(1617)

  • GC31731 structure
    GC31731GSK 4027
    CAS: 2079896-25-4
    纯度: >98.50%

    A PCAF/GCN5 bromodomain inhibitor

  • GC31831 structure
    GC31831BET-IN-1
    CAS: 1422554-34-4
    纯度: >99.00%

    BET-IN-1 是所有八个 BET 溴结构域的泛抑制剂，并且比其他具有代表性的含溴结构域的蛋白质具有选择性。

  • GC31866 structure
    GC31866JAK inhibitor 1
    CAS: 2096999-92-5

    JAK inhibitor 1 是从专利 US20170121327A1 化合物实施例 283 中提取的 JAK 抑制剂。

  • GC31881 structure
    GC31881MS417 (GTPL7512)
    CAS: 916489-36-6
    纯度: >99.50%

    MS417 (GTPL7512) 是一种选择性 BET 特异性 BRD4 抑制剂，与 BRD4-BD1 和 BRD4-BD2 结合，IC50 分别为 30、46 nM 和 Kds 分别为 36.1、25.4 nM，对 CBP BRD 的选择性较弱 (IC50, 32.7 μ ;M)。

  • GC31887 structure
    GC31887KDM4D-IN-1
    CAS: 2098902-68-0
    纯度: >99.50%

    KDM4D-IN-1 is a potent inhibitor of KDM4D with an IC50 of 0.41 μM.

  • GC31902 structure
    GC31902JAK3-IN-6
    CAS: 1443235-95-7
    纯度: >98.00%

    Selective JAK3 inhibitor 1 is an irreversible JAK3 inhibitor with Ki values of 0.07 nM, 320 nM, 740 nM for JAK3, JAK1 and JAK2 respectively. It is also selective over the other kinases possessing a cysteine in the same region as JAK3, such as BMX, EGFR, ITK, and BTK.

  • GC31999 structure
    GC31999JAK-IN-1
    CAS: 1334673-53-8

    JAK-IN-1是JAK1/2/3抑制剂，IC50分别为0.26，0.8和3.2nM。JAK-IN-1对JAK3的选择性比JAK1高。

  • GC32023 structure
    GC32023Abrocitinib (PF-04965842)
    CAS: 1622902-68-4
    纯度: >98.00%

    Abrocitinib (PF-04965842)是一种口服活性且选择性的Janus激酶（JAK）抑制剂，对JAK1和JAK2的IC 50 值分别为29nM和803nM。

  • GC32028 structure
    GC32028BMS-066
    CAS: 914946-88-6

    BMS-066是IKKβ/Tyk2的抑制剂，其IC50值分别为9nM，72nM。

  • GC32052 structure
    GC32052Tyk2-IN-3
    CAS: 1779493-12-7

    Tyk2-IN-3是Tyk2pseudokinase的一个抑制剂，其IC50值为485nM。

  • GC32081 structure
    GC32081GNE-781
    CAS: 1936422-33-1
    纯度: >98.00%

    GNE-781 (compound 19) is an orally active, highly potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP) with IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50 of 6.2 nM and 5100 nM, respectively. GNE-781 exhibits antitumor activity.

  • GC32083 structure
    GC32083Acriflavine
    CAS: 8048-52-0
    纯度: >98.00%

    Acriflavine是用于标记高分子量RNA的荧光染料。它也是一种局部防腐剂。

  • GC32228 structure
    GC32228Tilorone dihydrochloride
    CAS: 27591-69-1
    纯度: >99.50%

    An interferon-inducing antiviral agent

  • GC32435 structure
    GC32435Targapremir-210
    CAS: 1049722-30-6
    纯度: >98.00%

    Targapremir-210是有效的miR-210抑制剂，作用于MDA-MB-231细胞系的IC50值为200nM。Targapremir-210通过和miR-210的发夹前体结构结合，进而抑制miRNA的成熟。

  • GC32449 structure
    GC32449Desidustat
    CAS: 1616690-16-4
    纯度: >98.00%

    An inhibitor of HIF-PH

  • GC32565 structure
    GC32565CRA-026440
    CAS: 847460-34-8

    CRA-026440 是一种有效的广谱 HDAC 抑制剂。

  • GC32677 structure
    GC32677A-485
    CAS: 1889279-16-6
    纯度: >99.50% / >98.00%

    A-485是有效的选择性p300/CBP（组蛋白乙酰转移酶旁系同源物/CREB结合蛋白）的催化抑制剂，对p300 HAT的IC 50 值为60nM。A-485可抑制p300-BHC（溴域HAT-C/H3）和CBP-BHC结构域的活性，IC 50 分别为9.8nM和2.6nM。

  • GC32680 structure
    GC32680PT-2385
    CAS: 1672665-49-4
    纯度: >99.00%

    PT2385 is a HIF-2α antagonist with luciferase EC50 of 27 nM and no significant off-target activity.

  • GC32685 structure
    GC32685ARV-771
    CAS: 1949837-12-0
    纯度: >99.50%

    ARV-771是一种泛BET-PROTAC，能有效降解BRD2/3/4蛋白，DC 50 值低于5nM。

  • GC32689 structure
    GC32689666-15
    CAS: 1433286-70-4
    纯度: >99.50%

    666-15是一种选择性环磷酸腺苷反应元件结合蛋白（CREB）抑制剂，IC 50 值为0.081±0.04μM。

  • GC32693 structure
    GC32693GSK3326595 (EPZ015938)
    CAS: 1616392-22-3
    纯度: >99.50% / >99.00%

    GSK3326595 (EPZ015938) 是一种具有口服活性的、有效的、选择性protein arginine methyltransferase 5（PRMT5）抑制剂。

  • GC32699 structure
    GC32699QC6352
    CAS: 1851373-36-8
    纯度: >98.00%

    QC6352是一种有效的KDM4C抑制剂，其IC50值为35nM。

  • GC32719 structure
    GC32719dBET6
    CAS: 1950634-92-0
    纯度: >99.50%

    dBET6是一种新型的、具有口服活性的BRD4降解剂，可抑制c-Myc等致癌基因的转录和表达。

  • GC32724 structure
    GC32724LW6 (HIF-1α inhibitor)
    CAS: 934593-90-5
    纯度: >98.00%

    LW6是一种缺氧诱导因子1(hypoxia inducing factor 1, HIF)抑制剂,通过降解HIF-1α有效抑制HIF-1α的积累,但不影响缺氧时HIF- 1a mRNA水平。