Chromatin/Epigenetics
Chromatin/Epigenetics(染色质/表观遗传学)
Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
- Bromodomain(50)
- Aurora Kinase(63)
- DNA Methyltransferase(35)
- HDAC(210)
- Histone Acetyltransferases(78)
- Histone Demethylases(110)
- Histone Methyltransferase(240)
- HIF(102)
- JAK(173)
- MBT Domains(1)
- PARP(122)
- Pim(32)
- Protein Ser/Thr Phosphatases(34)
- RNA Polymerase(7)
- Sirtuin(77)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(21)
- Epigenetic Reader Domain(246)
- MicroRNA(24)
- Protein Arginine Deiminase(7)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(44)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(1)
- METTL3(2)
- WDR5(1)
- TET Protein(2)
- HuR(1)
- SF3B1(1)
Chromatin/Epigenetics 相关产品(1617)
- GC32791BETd-260 (ZBC 260)CAS: 2093388-62-4纯度: >98.00%
BETd-260 (ZBC 260)是一种基于蛋白水解靶向嵌合体（PROTAC）技术设计的异双功能小分子化合物，通过连接Cereblon配体和BET配体来发挥作用。
- GC32809Ilginatinib (NS-018)CAS: 1239358-86-1纯度: >99.00%
Ilginatinib (NS-018) (NS-018) 是一种高活性且具有口服生物利用度的 JAK2 抑制剂，其 IC50 为 0.72 nM，对 JAK2 的选择性是 JAK1 的 46、54 和 31 倍（IC50，33 nM）， JAK3 (IC50, 39 nM) 和 Tyk2 (IC50, 22 nM)。
- GC32820Seclidemstat (SP-2577)CAS: 1423715-37-0纯度: >99.50%
Seclidemstat (SP-2577) is a potent and orally bioavailable inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A) with IC50 of 13 nM. Seclidemstat (SP-2577) has potential antineoplastic activity.
- GC32863Target Protein-binding moiety 4CAS: 1300019-38-8纯度: >98.50%
Target Protein-binding moiety 4 (Molibresib carboxy acid) 是一种基于 I-BET762 的弹头配体，用于 PROTAC 靶向 BET 的共轭反应。 Target Protein-binding moiety 4 (Molibresib carboxy acid) 是一种 BRD4 抑制剂，pIC50 为 5.1。
- GC32973SID 3712249 (MiR-544 Inhibitor 1)CAS: 522606-67-3纯度: >99.00%
An inhibitor of miR-544 biogenesis
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC32745 | OSS_128167 | 887686-02-4 | >98.00% | |
OSS_128167是一种有效的选择性沉默调节蛋白6 (SIRT6)抑制剂，IC50为89 μM。 | ||||
| GC32747 | GNE-272 | 1936428-93-1 | >99.50% | |
GNE-272是一种有效和选择性的环磷酸腺苷反应元件结合蛋白（CBP）抑制剂，是E1A结合蛋白p300（EP300）的抑制剂，IC 50 值分别为0.02和0.03μM，也是CBP/EP300溴结构域体内探针。 | ||||
| GC32764 | GSK-LSD1 Dihydrochloride | 2102933-95-7 | >98.00% | |
An LSD1 inhibitor | ||||
| GC32790 | KDM5-IN-1 | 1628210-26-3 | >99.50% | |
KDM5-IN-1是高效选择，有口服活性的KDM5抑制剂，IC50值为15.1nM。 | ||||
| GC32791 | BETd-260 (ZBC 260) | 2093388-62-4 | >98.00% | |
BETd-260 (ZBC 260)是一种基于蛋白水解靶向嵌合体（PROTAC）技术设计的异双功能小分子化合物，通过连接Cereblon配体和BET配体来发挥作用。 | ||||
| GC32793 | Rucaparib Camsylate | 1859053-21-6 | >99.50% | |
A PARP1 inhibitor | ||||
| GC32798 | MI-538 | 1857417-10-7 | >99.00% | |
MI-538是menin和MLL融合蛋白相互作用的抑制剂；IC50值为21nM。 | ||||
| GC32809 | Ilginatinib (NS-018) | 1239358-86-1 | >99.00% | |
Ilginatinib (NS-018) (NS-018) 是一种高活性且具有口服生物利用度的 JAK2 抑制剂，其 IC50 为 0.72 nM，对 JAK2 的选择性是 JAK1 的 46、54 和 31 倍（IC50，33 nM）， JAK3 (IC50, 39 nM) 和 Tyk2 (IC50, 22 nM)。 | ||||
| GC32812 | BMS-986158 | 1800340-40-2 | >98.50% | |
A BET bromodomain inhibitor | ||||
| GC32820 | Seclidemstat (SP-2577) | 1423715-37-0 | >99.50% | |
Seclidemstat (SP-2577) is a potent and orally bioavailable inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A) with IC50 of 13 nM. Seclidemstat (SP-2577) has potential antineoplastic activity. | ||||
| GC32842 | KDM5A-IN-1 | 1905481-36-8 | >98.00% | |
KDM5A-IN-1是组蛋白去甲基化酶抑制剂。 | ||||
| GC32861 | A-196 | 1982372-88-2 | >98.00% | |
A selective inhibitor of SUV420H1 and SUV420H2 | ||||
| GC32863 | Target Protein-binding moiety 4 | 1300019-38-8 | >98.50% | |
Target Protein-binding moiety 4 (Molibresib carboxy acid) 是一种基于 I-BET762 的弹头配体，用于 PROTAC 靶向 BET 的共轭反应。 Target Protein-binding moiety 4 (Molibresib carboxy acid) 是一种 BRD4 抑制剂，pIC50 为 5.1。 | ||||
| GC32872 | DC_517 | 500017-70-9 | >99.00% | |
DC_517是一种DNMT1抑制剂，IC50和Kd值分别为1.7μM和0.91μM。 | ||||
| GC32876 | SYP-5 | 1384268-04-5 | >99.50% | |
A HIF-1 inhibitor | ||||
| GC32880 | TPOP146 | 2018300-62-2 | >99.50% | |
TPOP146是选择性的CBP/P300苯并西泮溴结构域抑制剂；对CBP和BRD4的Kd值分别为134nM和5.02μM。 | ||||
| GC32896 | NCGC00247743 | 1435192-04-3 | - | |
NCGC00247743是一种组蛋白赖氨酸脱甲基酶KDM4抑制剂。 | ||||
| GC32929 | MIR96-IN-1 | 1311982-88-3 | >98.00% | |
MIR96-IN-1选择性抑制微小RNA-96的生物合成,上调蛋白靶点(FOXO1)且诱导癌细胞凋亡。 | ||||
| GC32945 | THS-044 | 62054-67-5 | - | |
THS-044结合且稳定化HIF2αPAS-B折叠状态,调节HIF2活性。 | ||||
| GC32948 | IDF-11774 | 1429054-28-3 | - | |
IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. It reduces the HRE-luciferase activity of HIF-1α (IC50 = 3.65 μM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells. | ||||
| GC32958 | GDC-0339 | 1428569-85-0 | >99.50% | |
GDC-0339是Pim激酶抑制剂,作用于BaF3PIM1时,IC50为43.6nM。 | ||||
| GC32960 | GNE-049 | 1936421-41-8 | >98.50% | |
GNE-049是一种高效的选择性CBP抑制剂，在TR-FRET实验中IC50为1.1nM。GNE-049还抑制BRET和BRD4(1)，IC50分别为12nM和4200nM。 | ||||
| GC32964 | NKL 22 | 537034-15-4 | - | |
A selective HDAC1/3 inhibitor | ||||
| GC32973 | SID 3712249 (MiR-544 Inhibitor 1) | 522606-67-3 | >99.00% | |
An inhibitor of miR-544 biogenesis | ||||