RK-287107 is a potent and specific tankyrase inhibitor with IC50s of 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively. RK-287107 blocks colorectal cancer cell growth[1].
RK-87107 (0.01-10 μM; 12 hours) shows an antiproliferative effect on colorectal cancer cells harboring short adenomatous polyposis coli (APC) mutations. The 50% growth inhibition (GI50) value of RK-287107 on COLO-320DM cells is 0.449 μM[1].
RK-287107 (0.03-10 μM; 16 hours) causes accumulation of tankyrase and Axin1/2[1].
RK-287107 (0.03-10 μM; 16 hours) also downregulates β-catenin signaling in cultured cells[1].
RK-287107 (100 and 300 mg/kg; i.p. administration; once per day; 5-days on/ 2-days off schedule for 2 weeks) inhibits tumor growth in a mouse xenograft model[1].
Reference：
[1]. Mizutani A, et al. RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model. Cancer Sci. 2018 Dec;109(12):4003-4014.
RK-287107
目录号: GC19505纯度: >99.50%
A TNKS1/2 inhibitor
Cas No.: 2171386-10-8
| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 1mg | ¥514.00 | 现货 | 1 | |
| 5mg | ¥1,328.00 | 现货 | 1 | |
| 10mg | ¥2,104.00 | 现货 | 1 | |
| 25mg | ¥3,342.00 | 现货 | 1 | |
| 50mg | ¥4,939.00 | 现货 | 1 | |
| 10mM (in 1mL DMSO) | ¥1,216.00 | 现货 | 1 |
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产品描述 Description
产品文档 Product Documents
Purity:>99.50%
化学性质Chemical Properties
CAS 号
2171386-10-8
SMILES
O=C1NC(N2CCC3(CC2)CN(CCO)C4=C3C(F)=CC(F)=C4)=NC5=C1CCCC5
分子式
C₂₂H₂₆F₂N₄O₂
分子量
416.46 g/mol
溶解性
Soluble in DMSO
保存条件
4°C, protect from light
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储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
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计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度
g/mol