(±)11-HETE-d8 is intended for use as an internal standard for the quantification of (±)11-HETE by GC- or LC-MS. (±)11-HETE is an oxylipin formed non-enzymatically from arachidonic acid .1,2 Levels of (±)11-HETE are increased in an in vitro model of lipid peroxidation induced by ferrous ammonium sulfate (FAS) in rat brain homogenates.3 Levels are also increased in rat liver in an in vivo model of lipid peroxidation induced by carbon tetrachloride (CCl4). It has been found in skin extracts from individuals with psoriasis and in atherosclerotic plaques.4,5
1.Powell, W.S., and Rokach, J.Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acidBiochim. Biophys. Acta1851(4)340-355(2014) 2.Derogis, P.B.M.C., Chaves-Filho, A.B., and Miyamoto, S.Characterization of hydroxy and hydroperoxy polyunsaturated fatty acids by mass spectrometryBioactive lipids in health and disease21-38(2019) 3.Guido, D.M., McKenna, R., and Mathews, W.R.Quantitation of hydroperoxy-eicosatetraenoic acids and hydroxy-eicosatetraenoic acids as indicators of lipid peroxidation using gas chromatography-mass spectrometryAnal. Biochem.209(1)123-129(1993) 4.Camp, R.D.R., Mallet, A.I., Woollard, P.M., et al.The identification of hydroxy fatty acids in psoriatic skinProstaglandins26(3)431-447(1983) 5.Waddington, E., Sienuarine, K., Puddey, I., et al.Identification and quantitation of unique fatty acid oxidation products in human atherosclerotic plaque using high-performance liquid chromatographyAnal. Biochem.292(2)234-244(2001)