Chromatin/Epigenetics
Chromatin/Epigenetics(染色质/表观遗传学)
Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
- Bromodomain(50)
- Aurora Kinase(63)
- DNA Methyltransferase(35)
- HDAC(210)
- Histone Acetyltransferases(78)
- Histone Demethylases(110)
- Histone Methyltransferase(240)
- HIF(102)
- JAK(173)
- MBT Domains(1)
- PARP(122)
- Pim(32)
- Protein Ser/Thr Phosphatases(34)
- RNA Polymerase(7)
- Sirtuin(77)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(21)
- Epigenetic Reader Domain(246)
- MicroRNA(24)
- Protein Arginine Deiminase(7)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(44)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(1)
- METTL3(2)
- WDR5(1)
- TET Protein(2)
- HuR(1)
- SF3B1(1)
Chromatin/Epigenetics 相关产品(1617)
- GC39491GSK-3484862CAS: 2170136-65-7纯度: >98.00%
GSK-3484862 是 DNA 甲基转移酶 Dnmt1 的非共价抑制剂，通过诱导 DNA 低甲基化起抗癌作用。
- GC39663BI-9321 trihydrochlorideCAS: 2387510-87-2纯度: >98.50%
BI-9321 trihydrochloride 是一种有效的，选择性的，具有细胞活性的 NSD3-PWWP1 拮抗剂，Kd 值为 166 nM。BI-9321 对 NSD2-PWWP1 和 NSD3-PWWP2 无效。BI-9321 trihydrochloride 在 U2OS 细胞中特异性破坏 NSD3-PWWP1 与组蛋白相互作用，IC50 为 1.2 μM。
- GC39699Aurintricarboxylic acidCAS: 4431-00-9
A protein synthesis inhibitor with diverse biological activities
- GC39840AMI-1 free acidCAS: 134-47-4纯度: >97.00%
AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.
- GC40094all-trans Retinoic Acid-d5纯度: >99.00%
An internal standard for the quantification of all-trans retinoic acid
- GC40111Histone H3 (21-44) (human, mouse, rat, bovine) (trifluoroacetate salt)纯度: >95.00%
A peptide fragment of histone H3
- GC40113Histone H3K9Ac (1-24) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)纯度: >95.00%
A peptide fragment of histone H3
- GC40114Histone H3K4Me3 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)纯度: >95.00%
Histone H3K4Me3 (1-10) is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 2-11 of the human histone H3 sequence.
- GC40115Histone H3K79Ac (73-83) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)纯度: >95.00%
A peptide fragment of histone H3
- GC40117Histone H2B (21-35) (human, mouse, rat, bovine) (trifluoroacetate salt)纯度: >95.00%
A peptide fragment of histone H2B
- GC40226Curcumin-d6CAS: 1335198-02-1纯度: >99.00%
An internal standard for the quantification of curcumin
- GC40255Citrulline-specific Probe-biotinCAS: 2468149-70-2纯度: >75.00%
An affinity probe for citrullinated proteins
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC39394 | KDM5-C70 | 1596348-32-1 | >98.00% | |
An inhibitor of JARID1B | ||||
| GC39407 | MS1943 | 2225938-17-8 | >98.00% | |
A PROTAC that drives EZH2 degradation | ||||
| GC39417 | OXFBD04 | 2231747-03-6 | >99.00% | |
OXFBD04 是一种有效的选择性 BRD4 抑制剂，IC50 为 166 nM。OXFBD04 是一种有效的 BET 溴结构域配体，对 CREBBP 溴结构域具有额外的适度亲和力。OXFBD04 具有抗癌活性。 | ||||
| GC39435 | Scopolin | 531-44-2 | >98.00% | |
A coumarin glucoside with anti-inflammatory activity | ||||
| GC39485 | CK2/ERK8-IN-1 | 1085822-09-8 | >99.00% | |
A dual inhibitor of CK2 and ERK8 | ||||
| GC39491 | GSK-3484862 | 2170136-65-7 | >98.00% | |
GSK-3484862 是 DNA 甲基转移酶 Dnmt1 的非共价抑制剂，通过诱导 DNA 低甲基化起抗癌作用。 | ||||
| GC39551 | BRD3308 | 1550053-02-5 | >98.00% | |
An HDAC3 inhibitor | ||||
| GC39663 | BI-9321 trihydrochloride | 2387510-87-2 | >98.50% | |
BI-9321 trihydrochloride 是一种有效的，选择性的，具有细胞活性的 NSD3-PWWP1 拮抗剂，Kd 值为 166 nM。BI-9321 对 NSD2-PWWP1 和 NSD3-PWWP2 无效。BI-9321 trihydrochloride 在 U2OS 细胞中特异性破坏 NSD3-PWWP1 与组蛋白相互作用，IC50 为 1.2 μM。 | ||||
| GC39665 | CMP-5 | 880813-42-3 | >98.50% | |
CMP-5 是一种有效的选择性 PRMT5 抑制剂，对 PRMT1，PRMT4 和 PRMT7 酶无活性。CMP-5 在组蛋白的准备过程中，通过抑制 PRMT5 甲基转移酶活性选择性地阻断 S2Me-H4R3。CMP-5 阻断 EBV 驱动的 B 淋巴细胞转化，但对正常 B 细胞没有影响。 | ||||
| GC39679 | CG347B | 1598426-03-9 | >98.50% | |
CG347B 是一种选择性的 HDAC6 抑制剂。 | ||||
| GC39699 | Aurintricarboxylic acid | 4431-00-9 | - | |
A protein synthesis inhibitor with diverse biological activities | ||||
| GC39840 | AMI-1 free acid | 134-47-4 | >97.00% | |
AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively. | ||||
| GC40094 | all-trans Retinoic Acid-d5 | - | >99.00% | |
An internal standard for the quantification of all-trans retinoic acid | ||||
| GC40098 | BB-Cl-Yne | 2219324-71-5 | >98.00% | |
A clickable PAD inhibitor | ||||
| GC40111 | Histone H3 (21-44) (human, mouse, rat, bovine) (trifluoroacetate salt) | - | >95.00% | |
A peptide fragment of histone H3 | ||||
| GC40113 | Histone H3K9Ac (1-24) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
A peptide fragment of histone H3 | ||||
| GC40114 | Histone H3K4Me3 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
Histone H3K4Me3 (1-10) is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 2-11 of the human histone H3 sequence. | ||||
| GC40115 | Histone H3K79Ac (73-83) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
A peptide fragment of histone H3 | ||||
| GC40117 | Histone H2B (21-35) (human, mouse, rat, bovine) (trifluoroacetate salt) | - | >95.00% | |
A peptide fragment of histone H2B | ||||
| GC40226 | Curcumin-d6 | 1335198-02-1 | >99.00% | |
An internal standard for the quantification of curcumin | ||||
| GC40251 | TCEP-biotin | 2227020-26-8 | >95.00% | |
An affinity probe for protein lysine crotonylation | ||||
| GC40255 | Citrulline-specific Probe-biotin | 2468149-70-2 | >75.00% | |
An affinity probe for citrullinated proteins | ||||
| GC40468 | 1,5-Isoquinolinediol | 5154-02-9 | >99.00% | |
An inhibitor of poly(ADP-ribose) polymerases | ||||
| GC40496 | N6-Methyladenine | 443-72-1 | >98.00% | |
A modified purine of microbial genomes | ||||