Scopolin is a coumarin glucoside form of scopoletin that has been found in O. africana and has anti-inflammatory activity.1,2,3 It decreases the production of prostaglandin E2 and leukotriene C4 induced by A23187 in isolated mouse peritoneal macrophages when used at a concentration of 100 ?M.2 Scopolin (50 and 100 mg/kg) reduces synovial inflammation and fibrosis, as well as bone and cartilage erosion, in the inflamed joints in a rat model of rheumatoid arthritis induced by complete Freund’s adjuvant and M. butyricum.3
1.Tsukamoto, H., Hisada, S., and Nishibe, S.Coumarin and secoiridoid glucosides from bark of Olea africana and Olea capensisChem. Pharm. Bull.33(1)396-399(1984) 2.Silván, A.M., Abad, M.J., Bermejo, P., et al.Antiinflammatory activity of coumarins from Santolina oblongifoliaJ. Nat. Prod.59(12)1183-1185(1996) 3.Pan, R., Dai, Y., Gao, X., et al.Scopolin isolated from Erycibe obtusifolia Benth stems suppresses adjuvant-induced rat arthritis by inhibiting inflammation and angiogenesisInt. Immunopharmacol.9(7-8)859-869(2009)