Etoxazole is an organofluorine acaricide.1,2 It induces toxicity in two-spotted spider mite (T. urticae) larvae (LC50 = 0.036 mg/L for the London reference strain) through inhibition of chitin synthase 1. It reduces acetylcholinesterase (AChE) activity in the freshwater fish O. niloticus in a concentration-dependent manner.3 Etoxazole (2.2-22 mg/kg per day) inhibits the activity of catalase, glutathione peroxidase (GPX), and AChE in the liver and kidneys of rats in a dose-dependent manner.2 Formulations containing etoxazole have been used for the control of mites in agriculture.
1.Demaeght, P., Osborne, E.J., Odman-Maresh, J., et al.High resolution genetic mapping uncovers chitin synthase-1 as the target-site of the structurally diverse mite growth inhibitors clofentezine, hexythiazox and etoxazole in Tetranychus urticaeInsect Biochem. Mol. Biol.5152-61(2014) 2.Yilmaz, M., Rencuzogullari, E., and Canli, M.Investigations on the effects of etoxazole in the liver and kidney of Wistar ratsEnviron. Sci. Pollut. Res. Int.24(24)19635-19639(2017) 3.Sevgiler, Y., OruÇ, E.O., and Üner, N.Evaluation of etoxazole toxicity in the liver of Oreochromis niloticusPestic. Biochem. Physiol.78(1)1-8(2004)