Aristolochic acid C is an alkaloid originally isolated from Aristolochia argentina and a derivative of aristolochic acid that has anticancer activities.1,2,3 It inhibits the growth of LLC-PK1, P388, HT-29, and HL-60 cancer cells (IC50s = 85, 8.8, 17.1, and 40 ?M, respectively).1,2
1.Cai, Y., and Cai, T.-G.Two new aristolochic acid derivatives from the roots of Aristolochia fangchi and their cytotoxicitiesChem. Pharm. Bull. (Tokyo)58(8)1093-1095(2010) 2.Wu, T.-S., Chan, Y.-Y., and Leu, Y.-L.The constituents of the root and stem of Aristolochia cucurbitifolia Hayata and their biological activityChem. Pharm. Bull. (Tokyo)48(7)1006-1009(2000) 3.Kumar, V., Poonam, Prasad, A.K., et al.Naturally occurring aristolactams, aristolochic acids and dioxoaporphines and their biological activitiesNat. Prod. Rep.20(6)565-583(2003)