Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC71281 Chroman 1 dihydrochloride Chroman 1 dihydrochloride是一种高效、选择性的岩石抑制剂。
GC43265 Chromomycin A2

色霉素A2
An antibacterial and anticancer aureolic acid
GC52360 Chymotrypsin Substrate I, Colorimetric (trifluoroacetate salt)

Suc-GGF-pNA, Suc-Gly-Gly-Phe-pNA, Suc-Gly-Gly-Phe-p-Nitroanilide
A colorimetric chymotrypsin substrate
GC45764 Ciclopirox-d11 (sodium salt)

HOE 296b-d11
A neuropeptide with diverse biological activities
GC39810 CID44216842

Cdc42-IN-1
CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor with EC50s of 1.0 μM and 1.2 μM for Cdc42WT and Cdc42Q61L mutant in GTP binding assay, respectively.
GC12352 cis-trismethoxy Resveratrol

顺式白藜芦醇三甲醚,cis-Trimethoxy Stilbene
Potent antineoplastic agent
GC52367 Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide

Biotin-GQGKS(Cit)L(Cit)DLYEEEMRELRRQ, Biotin-GQGKSXLXDLYEEEMRELRRQ (X=Citrulline), Citrullinated VIM (G146R) (R144 + R146)-biotin
A biotinylated and citrullinated mutant vimentin peptide
GC52370 Citrullinated Vimentin (R144) (139-159)-biotin Peptide

Biotin-GQGKS(Cit)LGDLYEEEMRELRRQ, Biotin-GQGKSXLGDLYEEEMRELRRQ (X=Citrulline), Citrullinated VIM (R144)-biotin
A biotinylated and citrullinated vimentin peptide
GC14060 CK 666 An Arp2/3 inhibitor
GC15076 CK 869

CK-0157869
An inhibitor of the Arp2/3 complex
GC15894 CK-636

CK-0944636
An inhibitor of Arp2/3 complex action
GC73395 Clathrin-IN-4 Clathrin-IN-4（化合物8b）是一种Wiskostatin类似物，是网格蛋白介导的内吞作用的强效抑制剂，IC50为2.1μM。
GC43286 CMPD101 A GRK2 and GRK3 inhibitor
GC49345 Coelenterazine hcp

腔肠素HCP
A synthetic bioluminescent luciferin
GC74600 Cofetuzumab pelidotin

PF-06647020; ABBV-647; h6M24-vc0101
Cofetuzumab pelidotin（PF-06647020）是一种靶向PTK7的ADC，其包含人源化抗PTK7单克隆抗体，通过基于缬氨酸-瓜氨酸（vc）的可切割接头与auristatin微管抑制剂有效载荷auristain-0101连接。
GC40664 Colcemid

秋水仙碱,Demecolcine
Colcemid是一种细胞骨架抑制剂，可以在哺乳动物细胞或卵母细胞中诱导G2/M期的有丝分裂停滞或囊泡破裂（GVBD）期的减数分裂停滞。
GC13261 Colchicine

秋水仙碱
Colchicine（秋水仙碱）是一种可口服的生物碱，通过抑制β-微管蛋白聚合成微管来破坏细胞骨架功能，Colchicine抑制微管的IC₅₀为3 nM。
GC47117 Colchicine-d6

秋水仙素 d6
An internal standard for the quantification of colchicine
GC43300 Combretastatin A1

康普瑞汀A-1
An inhibitor of microtubule assembly
GC17631 Combretastatin A4

康普瑞汀; CRC 87-09
A potent inhibitor of tubulin polymerization
GC43307 Concanamycin B

刀豆素B
A potent and selective inhibitor of V-ATPases
GC43315 Corynecin IV A chloramphenicol-like bacterial metabolite
GC40663 Corynecin V

棒状杆菌素V
A chloramphenicol-like bacterial metabolite
GC63333 Cotosudil Cotosudil 是一种 ROCK 激酶抑制剂，可用于青光眼或高眼压症的研究。
GC16489 CP-466722 An ATM kinase inhibitor
GC43321 CPTH6 (hydrobromide) A Gcn5 and pCAF HAT inhibitor
GC19112 Crolibulin

EPC2407
Crolibulin (EPC2407) 是一种微管蛋白聚合抑制剂，具有有效的细胞凋亡诱导和细胞生长抑制作用。 Crolibulin 具有抗肿瘤活性。克罗利布林还具有心血管毒性和神经毒性。
GC45414 CRT0066854 A PKCι and PKCζ inhibitor
GC40482 Curvulin

2-乙酰基-3,5-二羟基苯乙酸乙酯
An inhibitor of microtubule assembly
GC18028 CVT-313

CVT 313;NG 26;CVT313;NG26;NG-26
A Cdk2 inhibitor
GC11252 CW069 An inhibitor of KIFC/HSET
GC15106 CYC116 A potent Aurora kinase inhibitor
GC13268 Cyclapolin 9 Cyclapolin 9 是一种有效的、选择性的和 ATP 竞争性的 polo 样激酶 1 (PLK1) 抑制剂，IC50 为 500 nM。 Cyclapolin 9 对其他激酶无活性。
GC49709 cyclo(RGDyC) (trifluoroacetate salt)

c(RGDyC), cyclo(Arg-Gly-Asp-D-Tyr-Cys)
A cyclic pentapeptide
GC43346 Cyclopamine-KAAD

3-酮-N-氨基乙基-N'-氨基己酰二氢肉桂酰环杷明,Cyclopamine-KAAD
A potent inhibitor of hedgehog signaling
GC47149 Cyclopiazonic Acid-13C20

CPA-13C20
A neuropeptide with diverse biological activities
GC43351 Cylindrospermopsin

柱孢藻毒素
A cyanotoxin
GC45877 CYM 5478 An S1P₂ agonist
GC35789 Cys-mcMMAD Cys-mcMMAD 可用于偶联抗体。MMAD 是一种有效的微管 (tubulin) 抑制剂。
GC68929 Cys-McMMAF Cys-McMMAF 是 AlMcMMAF 释放的有效载荷，AlMcMMAF 是一种抗 5T4 的人源化 A1 抗体，通过马来酰咪唑丙基连接物偶联到微管破坏 MMAF 。Cys-McMMAF 对两种肿瘤小鼠模型(H1975 和 MDA-MB-361-DYT2 模型) 均有抑癌效果。
GC43354 Cysmethynil

Icmt Inhibitor
An inhibitor of protein prenylation
GC11383 CYT997 (Lexibulin)

CYT-997
An inhibitor of microtubule polymerization
GC49863 Cytarabine 5′-monophosphate

ara-CMP, 1-β-D-Arabinofuranosylcytosine 5'-monophosphate, Cytosine Arabinoside monophosphate, NSC 99445
An active metabolite of cytarabine
GC45800 Cytarabine-13C3

Ara-C-13C3, 1-β-D-Arabinofuranosylcytosine-13C3
A neuropeptide with diverse biological activities
GC32890 Cytochalasin B (Phomin)

细胞松弛素B; Phomin
Cytochalasin B(细胞松弛素B)是一种可渗透细胞的真菌毒素,从Phoma属的子囊菌真菌中分离得到。
GC13440 Cytochalasin D

细胞松弛素D; Zygosporin A; NSC 209835

An inhibitor of actin polymerization
GC10870 Cytochalasin J

细胞松驰素J
An inhibitor of actin polymerization
GC43360 Cytostatin

磷酸己烷雌酚
A selective PP2A inhibitor
GC43361 Cytostatin (sodium salt) A selective PP2A inhibitor
GC91419 CYY292 CYY292是一种PDGFRα、PDGFRβ、FGFR1、-2和-3的抑制剂，它们的IC50分别为5.35、4.6、28、28和78 nM。