GlpBio

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

研究方向

Cell Cycle/Checkpoint 相关产品(1379)

  • GC14230 structure
    GC14230K03861
    CAS: 853299-07-7
    纯度: >98.00%

    K03861 (K03861) 是一种 II 型 CDK2 抑制剂，Kd 为 8.2 nM。 K03861 (K03861) 通过与活化细胞周期蛋白的结合竞争抑制 CDK2 活性。

  • GC14288 structure
    GC14288KX2-391
    CAS: 897016-82-9
    纯度: >99.00%

    A Src kinase inhibitor

  • GC14294 structure
    GC14294Cdk1/2 Inhibitor III
    CAS: 443798-47-8
    纯度: >98.50%

    A cell-permeable inhibitor of Cdk1 and Cdk2

  • GC14358 structure
    GC14358Rigosertib (ON-01910,Estybon)
    CAS: 1225497-78-8

    A potent inhibitor of Plk1

  • GC14413 structure
    GC14413KJ Pyr 9
    CAS: 581073-80-5
    纯度: >99.00%

    An inhibitor of c-Myc and v-Myc interaction with Max

  • GC14497 structure
    GC14497(S)-CCG-1423
    CAS: 2319939-24-5

    A stereoisomer of CCG-1423, a Rho inhibitor

  • GC14589 structure
    GC14589KF 38789
    CAS: 257292-29-8
    纯度: >98.00%

    KF 38789是一种新型的低分子量P选择素抑制剂，IC 50 为1.97μM。

  • GC14592 structure
    GC14592KW 2449
    CAS: 1000669-72-6
    纯度: >99.50%

    A multi-kinase inhibitor

  • GC14600 structure
    GC14600SB743921
    CAS: 940929-33-9
    纯度: >98.00%

    An Eg5 inhibitor

  • GC14644 structure
    GC14644SBE 13 HCl
    CAS: 1052532-15-6
    纯度: >98.50%

    A potent Plk1 inhibitor

  • GC14650 structure
    GC14650CGP60474
    CAS: 164658-13-3
    纯度: >98.50%

    A CDK inhibitor

  • GC14707 structure
    GC14707Purvalanol A
    CAS: 212844-53-6
    纯度: >99.00%

    A selective inhibitor of cyclin-dependent kinases

  • GC14772 structure
    GC14772CCT244747
    CAS: 1404095-34-6
    纯度: >99.00%

    A potent Chk1 inhibitor

  • GC14806 structure
    GC14806Vinorelbine ditartrate
    CAS: 125317-39-7
    纯度: >98.00%

    Vinorelbine ditartrate是一种抗有丝分裂药物，是紫杉醇（Paclitaxel）的一种半合成衍生物，通过抑制肿瘤细胞的微管聚合来发挥抗肿瘤作用，主要用于治疗非小细胞肺癌和转移性乳腺癌等恶性肿瘤。

  • GC14807 structure
    GC14807Fingolimod (FTY720) HCl
    CAS: 162359-56-0
    纯度: >99.50% / >99.00%

    芬戈莫德(FTY720)是一种免疫抑制剂,通常用于治疗多发性硬化症,也有抗癌作用,可以作为HDACi(组蛋白脱乙酰酶抑制剂)。

  • GC14857 structure
    GC14857LFM-A13
    CAS: 244240-24-2
    纯度: >99.50%

    A BTK inhibitor

  • GC14918 structure
    GC1491810074-G5
    CAS: 413611-93-5

    An inhibitor of c-Myc/Max dimerization

  • GC14929 structure
    GC14929Monastrol
    CAS: 254753-54-3;329689-23-8
    纯度: >99.50%

    Monastrol是一种强效且具细胞通透性的有丝分裂驱动蛋白Eg5抑制剂，其 IC 50 为14μM。

  • GC14986 structure
    GC14986CCG-100602
    CAS: 1207113-88-9
    纯度: >99.50%

    A Rho/MKL1 transcriptional pathway inhibitor

  • GC15047 structure
    GC15047PHA-793887
    CAS: 718630-59-2
    纯度: >98.00%

    A CDK inhibitor

  • GC15076 structure
    GC15076CK 869
    CAS: 388592-44-7
    纯度: >99.50%

    An inhibitor of the Arp2/3 complex

  • GC15084 structure
    GC150842-Methoxyestradiol (2-MeOE2)
    CAS: 362-07-2
    纯度: >99.50% / >98.00%

    2-Methoxyestradiol (2-MeOE2/2-Me)是一种HIF-1α抑制剂。

  • GC15170 structure
    GC15170SB 772077B dihydrochloride
    CAS: 607373-46-6
    纯度: >98.50%

    A ROCK1 and ROCK2 inhibitor

  • GC15171 structure
    GC15171Ac-LEVD-AFC
    CAS: 1092077-23-0

    A fluorogenic substrate for caspase-4