GlpBio

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

研究方向

Cell Cycle/Checkpoint 相关产品(1379)

  • GC15173 structure
    GC15173PD 0332991 (Palbociclib)
    CAS: 571190-30-2
    纯度: >99.50%

    PD 0332991 (Palbociclib) (PD 0332991) 是一种具有口服活性的选择性 CDK4 和 CDK6 抑制剂，IC50 值分别为 11 和 16 nM。 PD 0332991 (Palbociclib) 具有有效的抗增殖活性，可诱导癌细胞的细胞周期停滞，可用于 HR 阳性和 HER2 阴性乳腺癌和肝细胞癌的研究。

  • GC15215 structure
    GC15215Iso-Olomoucine
    CAS: 101622-50-8
    纯度: >98.00%

    An inactive stereoisomer of olomoucine

  • GC15285 structure
    GC15285MPC 6827 hydrochloride
    CAS: 917369-31-4
    纯度: >98.00%

    An inhibitor of tubulin polymerization with anticancer activity

  • GC15421 structure
    GC15421Palbociclib (PD0332991) Isethionate
    CAS: 827022-33-3
    纯度: >99.50% / >98.00%

    Palbociclib (PD 0332991) isethionate 是一种具有口服活性的选择性 CDK4 和 CDK6 抑制剂，IC50 值分别为 11 和 16 nM。 Palbociclib (PD0332991) Isethionate 具有有效的抗增殖活性，可诱导癌细胞的细胞周期停滞，可用于 HR 阳性和 HER2 阴性乳腺癌和肝细胞癌的研究。

  • GC15478 structure
    GC154786H05
    CAS: 1469338-01-9

    An allosteric inhibitor of oncogenic K-Ras(G12C)

  • GC15514 structure
    GC15514Phomopsin A
    CAS: 64925-80-0

    A β-tubulin inhibitor

  • GC15588 structure
    GC15588PHA-848125
    CAS: 802539-81-7
    纯度: >99.50%

    An inhibitor of Cdks

  • GC15592 structure
    GC15592Moniliformin (sodium salt)
    CAS: 71376-34-6
    纯度: >99.50%

    A mycotoxin

  • GC15597 structure
    GC15597AT7519 trifluoroacetate
    CAS: 1431697-85-6
    纯度: >98.00%

    AT7519 (AT7519M) TFA 作为一种有效的 CDK 抑制剂，对 CDK1、CDK2、CDK4 到 CDK6 和 CDK9 的 IC50 分别为 210、47、100、13、170 和 <10 nM。

  • GC15598 structure
    GC15598Ac2-26
    CAS: 151988-33-9
    纯度: >99.00% / >98.50%

    An annexin A1-mimetic peptide

  • GC15607 structure
    GC15607ON123300
    CAS: 1357470-29-1
    纯度: >99.00%

    A multi-kinase inhibitor

  • GC15659 structure
    GC15659GSK-923295
    CAS: 1088965-37-0
    纯度: >98.00%

    An inhibitor of CENP-E

  • GC15671 structure
    GC15671Latrunculin A
    CAS: 76343-93-6
    纯度: >95.00%

    一种可逆抑制肌动蛋白聚合的药物

  • GC15739 structure
    GC15739CHIR-124
    CAS: 405168-58-3
    纯度: >98.00%

    A selective Chk1 inhibitor

  • GC15745 structure
    GC15745Mps1-IN-2
    CAS: 1228817-38-6
    纯度: >98.00%

    An inhibitor of Mps1

  • GC15773 structure
    GC15773Myoseverin
    CAS: 267402-71-1
    纯度: >99.00%

    A microtubule-binding trisubstituted purine

  • GC15777 structure
    GC15777Verdinexor (KPT-335)
    CAS: 1392136-43-4

    An inhibitor of XPO1

  • GC15798 structure
    GC15798MMAD
    CAS: 203849-91-6
    纯度: >99.50%

    MMAD 是一种有效的微管蛋白抑制剂，是抗体药物偶联物 (ADC) 中的一种毒素有效载荷。

  • GC15841 structure
    GC15841Alsterpaullone
    CAS: 237430-03-4
    纯度: >98.00%

    A dual CDK and GSK3 inhibitor

  • GC15870 structure
    GC15870AT7519
    CAS: 844442-38-2
    纯度: >99.50%

    A Cdk inhibitor

  • GC15894 structure
    GC15894CK-636
    CAS: 442632-72-6
    纯度: >98.00%

    An inhibitor of Arp2/3 complex action

  • GC15940 structure
    GC15940PalMitoyl Tripeptide-1
    CAS: 147732-56-7

    A form of GHK containing palmitic acid

  • GC16030 structure
    GC16030MK-1775
    CAS: 955365-80-7
    纯度: >99.50%

    MK-1775 是一种有效的选择性 Wee1 激酶小分子抑制剂，IC50 值为 5.2 nM。

  • GC16063 structure
    GC16063Flavopiridol
    CAS: 146426-40-6
    纯度: >98.00%

    An inhibitor of cyclin-dependent kinases