Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC68147 dAURK-4 hydrochloride dAURK-4 hydrochloride 是 Alisertib 的一种衍生物，是一种有效的选择性 AURKA (Aurora A) 降解剂。dAURK-4 hydrochloride 具有抗癌作用。
GC49913 Davunetide (acetate)

AL-108, NAP, NAPVSIPQ
A neuroprotective ADNP-derived peptide
GC74061 DBM-C5-VC-PAB-MMAE DBM-C5-VC-PAB-MMAE（化合物3a）是ADC的药物连接物偶联物。
GC74000 DBPR728 DBPR728是6K465的酰基前药，携带较少的氢键供体。
GC43385 DC-Chol (hydrochloride)

O-[(N,N-二甲基氨基乙基)-氨基甲酰基]胆固醇盐酸盐,?Cholesteryl 3β-N-(dimethylaminoethyl)carbamate
对于DC -Chol（盐酸盐），Aβ；在 Aβ40 (30 µM) 与低浓度 DC-Chol（盐酸盐）(50 ng/mL) 共孵育的图像中观察到纤维。
GC39486 DCLK1-IN-1 DCLK1-IN-1是DCLK1和DCLK2的高选择性抑制剂，在KINOMEscan结合试验中对DCLK1和DCLK2的IC₅₀分别为9.5nM和31nM。在ATP激酶实验中的IC₅₀分别为57nM和103nM。
GN10426 Deacetyltaxol

10-去乙酰紫杉醇; 10-Deacetylpaclitaxel
An anticancer taxane
GC92030 Debio 0123 (hydrochloride)

WEE1-IN-5; WEE1 Inhibitor 5
Debio 0123 (hydrochloride)是检查点激酶WEE1的抑制剂，IC50 = 0.8 nM。
GC18666 Debromohymenialdisine

DBH, SKF 108753
An inhibitor of Chk1 and Chk2
GC11835 Deferasirox

地拉罗司; ICL 670
Deferasirox是一种具口服活性的铁螯合剂，用于治疗铁过载疾病。
GC41304 Deoxybrevianamide E A fungal metabolite
GC38564 Deoxypodophyllotoxin

脱氧鬼臼毒素
A flavolignan with diverse biological activities
GC47211 Dichlorvos

敌敌畏
An organophosphate insecticide
GC49293 Dichlorvos-d6

敌敌畏
An internal standard for the quantification of dichlorvos
GC74280 Dihydrobaicalein Dihydrobaicalein是一种PLK1抑制剂，IC50为6.3μM。
GC43461 Dihydrocytochalasin B

二氢细胞松弛素 B
An inhibitor of actin assembly and cytokinesis
GC43467 Dimethyldioctadecylammonium (bromide)

双十八烷基二甲基溴化铵
A cationic amphipathic lipid
GC32969 Dimethylenastron

2,3,4,6,7,8-六氢-4-(3-羟基苯基)-7,7-二甲基-2-硫代-5(1H)-喹唑啉酮
An inhibitor of EG5
GC43469 Diminutol

NG72
An NQO1 inhibitor
GC17648 Dinaciclib(SCH727965)

(2S)-1-[3-乙基-7-[[(1-氧代-3-吡啶基)甲基]氨基]吡唑并[1,5-A]嘧啶-5-基]-2-哌啶乙醇,SCH 727965
A CDK inhibitor
GC43472 Dios-Arg (trifluoroacetate salt) A steroid-based cationic lipid
GC47237 Dipyridamole-d16 A neuropeptide with diverse biological activities
GC19773 Direct Red 80

天狼猩红; Sirius Red

直接红80
GC72959 DJ4 DJ4是ROCK1/2（IC50值：5和50 nM）和MRCKα/β（IC50值为10和100 nM）的ATP竞争性抑制剂。
GC60143 DM3

Maytansinoid DM3
DM3 (Maytansinoid DM3) 是一种带有二硫键或硫醇基的美登素类似物，是一种 tubulin 的抑制剂，还是一种抗体-药物偶联物 (ADCs) 的细胞毒性部分。
GC38355 DM3-SMe DM3-SMe 是一种美登素衍生物，是一种微管蛋白 (tubulin) 抑制剂，是一种抗体-药物偶联物 (ADCs) 的细胞毒性部分，可通过二硫键或稳定的硫醚键与抗体连接。DM3-SMe 在体外显示出高度的细胞毒性活性，IC50 为 0.0011 nM。
GC32810 DM4

N2'-去乙酰基-N2'-(4-巯基-4-甲基-1-氧代戊基)-美登素
A derivative of maytansine
GC38468 DM4-SMe DM4-SMe 是抗体-美登素偶联物 (AMC) 的代谢产物，是一种微管蛋白 (tubulin) 抑制剂，还是一种抗体-药物偶联物 (ADCs) 的细胞毒性部分，可通过二硫键或稳定的硫醚键与抗体连接。DM4-SMe 抑制 KB 细胞的增殖，IC50 值为 0.026 nM。
GC38460 DM4-SPDP DM4-SPDP 是由连接桥 SPDP 和毒性分子 DM4 连接而成的，可用来制备抗体偶联药物。DM4 是抑制细胞分裂的抗微管蛋剂。SPDP 是一种短链交联剂，可通过 NHS-酯和吡啶基二硫醇反应性基团与半胱氨酸巯基形成可裂解的 (可还原的) 二硫键，实现胺与巯基的结合。
GC43542 Dnp-GPLGMRGL-NH2 (trifluoroacetate salt)

Dnp-Gly-Pro-Leu-Gly-Met-Arg-Gly-Leu-NH2, Matrix Metalloproteinase-13 Substrate, MMP-13 Substrate
A peptide substrate for MMP-13
GC43544 Dnp-P-Cha-Abu-Cys(Me)-HA-K(Nma)-NH2

Dnp-Pro-Cha-Abu-Cys(Me)-His-Ala-Lys(Nma)-NH2, Matrix Metalloproteinase-1 Fluorogenic Substrate III, MMP-1 Fluorogenic Substrate III
A fluorogenic substrate for MMP-1 and MMP-9
GC43545 Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2

Dnp-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(Nma)-NH2, Matrix Metalloproteinase-1/Matrix Metalloproteinase-9 Fluorogenic Substrate, MMP-1/MMP-9 Fluorogenic Substrate
A fluorogenic substrate for MMP-1 and MMP-9
GC43546 Dnp-PLALWAR (trifluoroacetate salt)

Matrix Metalloproteinase-1 Fluorogenic Substrate I, MMP-1 Fluorogenic Substrate I
A fluorogenic substrate for MMP-1 and MMP-8
GC43547 Dnp-PLAYWAR (trifluoroacetate salt)

Dnp-Pro-Leu-Ala-Tyr-Trp-Ala-Arg-OH, Matrix Metalloproteinase-8/Matrix Metalloproteinase-26 Fluorogenic Substrate, MMP-8/MMP-26 Fluorogenic Substrate
A fluorogenic substrate for MMP-8 and MMP-26
GC43548 Dnp-PLG-Cys(Me)-HA-DArg-NH2 (trifluoroacetate salt)

Dnp-Pro-Leu-Gly-Cys(Me)-His-Ala-DArg-NH2, Matrix Metalloproteinase-1 Substrate II, MMP-1 Substrate II
A peptide substrate for MMP-1
GC43549 Dnp-PLGLWA-DArg-NH2 (trifluoroacetate salt) A fluorogenic substrate for MMP-1, MMP-2, MMP-7, and MMP-9
GC43550 Dnp-PLGMWSR (trifluoroacetate salt)

Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-OH, Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Fluorogenic Substrate I, MMP-2/MMP-9 Fluorogenic Substrate I
A fluorogenic substrate for MMP-2 and MMP-9
GC43552 Dnp-RPLALWRS (trifluoroacetate salt)

Dnp-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-OH, Matrix Metalloproteinase-7 Fluorogenic Substrate, MMP-7 Fluorogenic Substrate
A fluorogenic substrate for MMP-7
GC16684 Docetaxel

多西他赛; RP-56976
Docetaxel是紫杉烷类抗有丝分裂化疗药物,IC50为0.2 µM。
GC48968 Docetaxel (hydrate)

多烯紫杉醇三水合物(非药典标准品)
A microtubule-stabilizing agent
GC12550 Docetaxel Trihydrate

三水多烯紫杉醇,Taxotere Trihydrate
Docetaxel Trihydrate (RP-56976 Trihydrate) 是一种抗肿瘤剂，可抑制微管解聚，IC50 值为 0.2 μM。 Docetaxel Trihydrate 是紫杉醇的半合成类似物，可减弱 bcl-2 和 bcl-xL 基因表达的影响。 Docetaxel Trihydrate 在 G2/M 停止细胞周期并导致细胞凋亡。
GC47250 Docetaxel-d9

多烯紫杉醇D9,RP-56976-d9
An internal standard for the quantification of docetaxel
GC52095 Dodecyltrimethylammonium (bromide)

十二烷基三甲基溴化铵
A cationic surfactant
GC16273 Dolastatin 10

DLS 10; NSC 376128
Dolastatin 10 (DLS 10) 是一种有效的抗有丝分裂肽，可抑制微管蛋白聚合。
GC10557 Dolastatin 10 trifluoroacetate Antitumor agent
GA21397 Dolastatin 15

DLS 15
A peptide with anticancer activity
GC90366 Dolastatin 15 (trifluoroacetate salt)

NSC 617668

一种具有抗癌活性的肽。
GC43567 DPC-AJ1951 (trifluoroacetate salt) A peptide PPR agonist
GC91782 DPP-9 Inhibitor 42

Dipeptidyl Peptidase 9 Inhibitor 42
DPP-9 inhibitor 42 is an inhibitor of dipeptidyl peptidase 9 (DDP-9; IC50 = 0.0034 µM).
GC64927 Drp1-IN-1 Drp1-IN-1 (comp A-7) 是Drp1 蛋白的抑制剂，其IC50 值为0.91 μM。