GlpBio

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

研究方向

Cell Cycle/Checkpoint 相关产品(1379)

  • GC12871 structure
    GC12871CDK9 inhibitor
    CAS: 1415559-43-1
    纯度: >98.50%

    CDK9 inhibitor 是一种新型的选择性 CDK9 抑制剂，用于治疗 HIV 感染，对 CDK9/CycT1 的 IC50 为 39 nM，从参考化合物 87 中提取。

  • GC12886 structure
    GC12886NSC 625987
    CAS: 141992-47-4

    A Cdk4/cyclin D1 complex inhibitor

  • GC13096 structure
    GC13096MLS-573151
    CAS: 10179-57-4
    纯度: >99.50%

    A specific inhibitor of Cdc42

  • GC13100 structure
    GC13100[Ala92]-p16 (84-103)
    CAS: 189064-08-2

    inhibitor of cyclin-dependent kinase-4 (cdk4)/cyclin D1

  • GC13210 structure
    GC13210Flubendazole
    CAS: 31430-15-6
    纯度: >99.50%

    An anthelmintic

  • GC13332 structure
    GC13332Aurora A Inhibitor I
    CAS: 1158838-45-9
    纯度: >99.00%

    A potent and selective inhibitor of Aurora A kinase

  • GC13400 structure
    GC13400Ac-VDVAD-AFC
    CAS: 210344-94-8

    A fluorogenic substrate for caspase-2

  • GC13440 structure
    GC13440Cytochalasin D
    CAS: 22144-77-0
    纯度: >95.00% / >98.00%

    An inhibitor of actin polymerization

  • GC13448 structure
    GC13448NSC 109555 ditosylate
    CAS: 66748-43-4

    An inhibitor of Chk2

  • GC13491 structure
    GC13491Mirin
    CAS: 1198097-97-0
    纯度: >99.50%

    Mirin是一种Mre11-Rad50-Nbs1（MRN）复合物抑制剂（IC 50 =12μM），能够抑制Mre11相关的外切酶活性，Mirin可抑制MRN依赖的ATM的激活。通常用于与DNA修复机制相关的癌症的研究。

  • GC13511 structure
    GC13511THZ2
    CAS: 1604810-84-5
    纯度: >99.50%

    A Cdk7 inhibitor

  • GC13606 structure
    GC13606CFI-400945
    CAS: 1338800-06-8

    orally available, selective inhibitor of polo-like kinase 4 (PLK4)

  • GC13649 structure
    GC13649Arcyriaflavin A
    CAS: 118458-54-1

    A CDK4 and CAMKII inhibitor

  • GC13690 structure
    GC13690BS-181 HCl
    CAS: 1397219-81-6
    纯度: >99.00%

    A selective Cdk7 inhibitor

  • GC13727 structure
    GC13727TC Mps1 12
    CAS: 1206170-62-8
    纯度: >99.00%

    TC Mps1 12 是一种有效的选择性单极纺锤体 1 (Mps1) 抑制剂，IC50 为 6.4 nM。

  • GC13759 structure
    GC13759SAR407899
    CAS: 923359-38-0
    纯度: >99.00%

    A ROCK1 and ROCK2 inhibitor

  • GC13859 structure
    GC13859Z-DEVD-AFC
    CAS: 1135416-11-3

    A caspase-3 fluorogenic substrate

  • GC13928 structure
    GC13928HMN-214
    CAS: 173529-46-9
    纯度: >99.50% / >98.00%

    A prodrug form of HMN-176

  • GC13998 structure
    GC13998AT7519 Hydrochloride
    CAS: 902135-91-5
    纯度: >99.00%

    A Cdk inhibitor

  • GC14002 structure
    GC14002Bohemine
    CAS: 189232-42-6
    纯度: >98.00%

    A Cdk inhibitor

  • GC14060 structure
    GC14060CK 666
    CAS: 442633-00-3
    纯度: >99.50%

    CK 666是一种可穿透细胞的肌动蛋白相关蛋白Arp2/3复合物抑制剂（IC 50 =12μM）。

  • GC14075 structure
    GC14075Nocodazole
    CAS: 31430-18-9
    纯度: >99.50% / >98.00%

    Nocodazole是一种抗有丝分裂药物，是一种快速可逆的微管聚合抑制剂，在无细胞试验中抑制Abl，Abl（E255K）和Abl（T315I），IC 50 值分别为0.21μM，0.53μM和0.64μM。

  • GC14182 structure
    GC14182Kenpaullone
    CAS: 142273-20-9
    纯度: >98.00%

    A inhibitor of cyclin-dependent kinase and GSK3β

  • GC14186 structure
    GC141863MB-PP1
    CAS: 956025-83-5
    纯度: >98.00%

    An inhibitor of analog-sensitive Plk1 alleles