Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC33006 CCT020312 CCT020312是一种选择性蛋白激酶R样内质网激酶（PERK）通路激动剂。
GC11310 CCT129202

2-[4-[6-氯-2-(4-二甲基氨基苯基)-3H-咪唑并[4,5-B]吡啶-7-基]哌嗪-1-基]-N-(噻唑-2-基)乙酰胺,CCT-129202, CCT 129202
An Aurora kinase inhibitor
GC14566 CCT137690

甲磺酸阿贝西尼
An inhibitor of Aurora kinases and FLT3
GC18053 CCT241533

(3R,4S)-4-[[2-(5-氟-2-羟基苯基)-6,7-二甲氧基-4-喹唑啉基]氨基]-ALPHA,ALPHA-二甲基-3-吡咯烷甲醇,CCT 241533;CCT-241533
A selective Chk2 inhibitor
GC17105 CCT241533 hydrochloride

CCT241533盐酸盐,CCT-241533 hydrochloride;CCT 241533 hydrochloride
A selective Chk2 inhibitor
GC19092 CCT241736 A dual inhibitor of Aurora kinases and FLT3
GC14772 CCT244747

3-[(1R)-2-(二甲基氨基)-1-甲基乙氧基]-5-[[4-甲氧基-5-(1-甲基-1H-吡唑-4-基)-2-吡啶基]氨基]-2-吡嗪甲腈
A potent Chk1 inhibitor
GC33213 CCT251455 CCT251455是有效和选择性的有丝分裂激酶单极纺锤体1(MPS1)抑制剂，IC50值为3nM。
GC18051 CCT251545 analogue, Compound 51
Potent, Selective, orally bioavailable CDK 8/19 Inhibitor
GC48982 CD532 An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction
GC62189 CD532 hydrochloride An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction
GC12425 CDK inhibitor II

CDK inhibitorII
CDK inhibitor II 是一种有效且特异性的 CDK9 抑制剂，IC50 <8 nM，取自参考文献 1，实施例 4。
GC43217 CDK/CRK Inhibitor

Cdk7 Inhibitor IV, Cyclin-dependent kinase 7 Inhibitor IV, Cyclin-dependent kinase/CDK-related kinase Inhibitor, RGB-286147
A CDK/CRK-specific kinase inhibitor
GC14294 Cdk1/2 Inhibitor III

Cyclin-dependent kinase 1/2 Inhibitor III
A cell-permeable inhibitor of Cdk1 and Cdk2
GC43219 Cdk2 Inhibitor II

Cyclin-dependent kinase 2 Inhibitor II, SC-221409
Selective and potent inhibitor of Cdk2
GC11785 CDK4 inhibitor

瑞博西尼
An antiproliferative cyclin D1/Cdk4 inhibitor
GC11564 Cdk4/6 Inhibitor IV

CINK4
A cell-permeable inhibitor of Cdk4/6
GC12871 CDK9 inhibitor

N-[5-[[6-[3-(1,3-二氧代异吲哚-2-基)苯基]嘧啶-4-基]氨基]-2-甲基苯基]甲烷磺酰胺
CDK9 inhibitor 是一种新型的选择性 CDK9 抑制剂，用于治疗 HIV 感染，对 CDK9/CycT1 的 IC50 为 39 nM，从参考化合物 87 中提取。
GC17359 CDK9 inhibitor 2

N2'-(反式-4-氨基环己基)-5'-氯-N6-[(3-氟苯基)甲基]-[2,4'-联吡啶]-2',6-二胺
CDK9 inhibitor 2 是一种特殊的细胞周期蛋白依赖性激酶 9 (CDK9) 抑制剂，提取自专利 WO/2012131594A1，化合物 CDKI(8)，在 H929 多发性骨髓瘤 (MM) 细胞系中的 IC50 分别为 5 nM 和 7 nM（72 小时） ) 和 A2058 皮肤细胞系（72 小时）。
GC35651 Cenisertib

AS-703569; R-763
Cenisertib (AS-703569) 是一种多激酶抑制剂，可抑制 Aurora-kinase-A/B，ABL1，AKT，STAT5, FLT3 的活性。 Cenisertib 通过抑制肿瘤肥大细胞 (MC) 中几种不同分子靶标的活性抑制其生长。 Cenisertib 抑制异种移植模型中胰腺癌，乳腺癌，结肠癌，卵巢癌和肺癌以及白血病的肿瘤生长。
GC32688 Centrinone (LCR-263)

LCR-263
A Plk4 inhibitor
GC32751 Centrinone-B (LCR-323)

LCR-323
Centrinone-B (LCR-323) (LCR-323) 是一种有效且高度选择性的 PLK4 抑制剂，Ki 为 0.59 nM。
GN10780 Cephalomannine

三尖杉宁碱
A taxane diterpenoid
GC52489 Ceramide (hydroxy) (bovine spinal cord) A sphingolipid
GC52485 Ceramide (non-hydroxy) (bovine spinal cord) A sphingolipid
GC52486 Ceramide Phosphoethanolamine (bovine)

N-Acyl Ceramide Phosphoethanolamine (d18:1/acyl mixture), CPE, N-acyl-D-erythro-Sphingosylphosphorylethanolamine
A sphingolipid
GC43229 Ceramide Phosphoethanolamines (bovine) Ceramide phosphoethanolamine (CPE) is an analog of sphingomyelin that contains ethanolamine rather than choline as the head group.
GC47073 Ceramides (hydroxy) A mixture of hydroxy fatty acid-containing ceramides
GC43230 Ceramides (non-hydroxy) Ceramides are generated from sphingomyelin through activation of sphingomyelinases or through the de novo synthesis pathway, which requires the coordinated action of serine palmitoyl transferase and ceramide synthase.
GC35654 Ceratamine A Ceratamine A 是从海绵 Pseudoceratina sp. 中分离出的一种抗有丝分裂杂环生物碱，能作为一种微管稳定剂。Ceratamine A 对人类癌细胞系具有细胞毒性。
GC60688 Cereblon modulator 1

CC-90009
A modulator of cereblon
GC47074 Cerebroside C

脑苷脂C
A fungal metabolite
GC11905 Cevipabulin

5-氯-6-[2,6-二氟-4-[3-(甲基氨基)丙氧基]苯基]-N-((1S)-2,2,2-三氟-1-甲基乙基)-[1,2,4]三唑并[1,5-A]嘧啶-7-胺,TTI-237
An activator of microtubule polymerization
GC35659 Cevipabulin fumarate

TTI-237 fumarate
An activator of microtubule polymerization
GC13606 CFI-400945
orally available, selective inhibitor of polo-like kinase 4 (PLK4)
GC35660 CFI-400945 free base
CFI-400945 free base 是一种高效，选择性的，可口服的 PLK4 抑制剂，Ki 和 IC50 值分别为 0.26 nM 和 2.8 nM。
GC14526 CGK733

ATM/ATR Kinase Inhibitor
An anticancer compound
GC50175 CGP 74514 dihydrochloride Potent cdk1 inhibitor
GC48992 CGP 77675 (hydrate) An inhibitor of Src family kinases
GC14650 CGP60474

3-[[4-[2-[(3-氯苯基)氨基]-4-嘧啶基]-2-吡啶基]氨基]-1-丙醇,CGP-60474;CGP 60474
A CDK inhibitor
GC62145 Chiauranib

CS2164
Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.
GC15739 CHIR-124

4-[((3S)-1-氮杂双环[2,2,2]辛-3-基)氨基]-3-(1H-苯并咪唑-2-基)-6-氯喹啉-2(1H)-酮
A selective Chk1 inhibitor
GC43239 Chk2 Inhibitor

SC-203885
A Chk2 inhibitor
GC47078 Chlorambucil-d8

CB-1348-d8; WR-139013-d8
苯丁酸氮芥 (CB-1348-d8) 是氘标记的苯丁酸氮芥。苯丁酸氮芥 (CB-1348) 是一种具有口服活性的抗肿瘤剂，是一种属于氮芥类的双功能烷化剂。苯丁酸氮芥可用于淋巴细胞白血病、卵巢癌和乳腺癌以及霍奇金病的研究。
GC47079 Chloramine-T (hydrate)

氯氨T
A common reagent
GC43250 Cho-Arg (trifluoroacetate salt) A steroid-based cationic lipid
GC50145 CHR 6494 trifluoroacetate A selective Haspin protein kinase inhibitor
GC17254 CHR-6494

3-(1H-吲唑-5-基)-N-丙基咪唑并[1,2-B]哒嗪-6-胺,CHR 6494;CHR6494
A selective Haspin protein kinase inhibitor
GC16097 Chroman 1

(3S)-N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-3,4-二氢-6-甲氧基-2H-1-苯并吡喃-3-甲酰胺,ROCK-II inhibitor
A ROCK2 inhibitor
GC49334 Chroman 1 (hydrochloride hydrate)

(S)-Chroman 1
A ROCK2 inhibitor