GlpBio

Cell Cycle/Checkpoint

Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

研究方向

Cell Cycle/Checkpoint 相关产品(1379)

  • GC11905 structure
    GC11905Cevipabulin
    CAS: 849550-05-6
    纯度: >99.50%

    An activator of microtubule polymerization

  • GC11944 structure
    GC11944PF 4800567 hydrochloride
    CAS: 1391052-28-0

    A selective CK1ε inhibitor

  • GC11947 structure
    GC11947Ansamitocin P-3
    CAS: 66547-09-9
    纯度: >98.00%

    A microtubule depolymerizing agent

  • GC11971 structure
    GC11971LY2857785
    CAS: 1619903-54-6
    纯度: >98.50%

    A Cdk9 inhibitor

  • GC12001 structure
    GC12001BS-181
    CAS: 1092443-52-1

    A selective Cdk7 inhibitor

  • GC12064 structure
    GC12064SB1317
    CAS: 937270-47-8
    纯度: >99.50%

    A multi-kinase inhibitor

  • GC12092 structure
    GC12092TMPyP4 tosylate
    CAS: 36951-72-1
    纯度: >98.00% / >95.00%

    TMPyP4 tosylate是一种四链体特异性配体，可以抑制G-四链体与胰岛素样生长因子I（IGF-1）之间的相互作用。

  • GC12286 structure
    GC12286Vinblastine sulfate
    CAS: 143-67-9
    纯度: >99.50% / >98.00%

    Vinblastine sulfate是一种细胞毒性生物碱。

  • GC12314 structure
    GC123143-(4-Pyridyl)indole
    CAS: 7272-84-6
    纯度: >98.00%

    A ROCK1 and ROCK2 inhibitor

  • GC12319 structure
    GC12319Ferulenol
    CAS: 6805-34-1
    纯度: >95.00%

    A prenylated 4-hydroxycoumarin

  • GC12338 structure
    GC12338Wortmannin
    CAS: 19545-26-7
    纯度: >99.50% / >98.00% / >99.00%

    渥曼青霉素是一种高效的 PI3 激酶特异性直接抑制剂，最初源自真菌 (1,2)。

  • GC12348 structure
    GC12348Ro 3306
    CAS: 872573-93-8
    纯度: >98.00%

    Ro 3306是一种ATP竞争性抑制剂，主要靶向CDK1/cyclin B1（K i 值为35nmol/L）和CDK1/cyclin A复合物（K i 值为110nmol/L）。

  • GC12352 structure
    GC12352cis-trismethoxy Resveratrol
    CAS: 94608-23-8
    纯度: >98.00%

    Potent antineoplastic agent

  • GC12402 structure
    GC12402LX7101 HCL
    CAS: 1192189-69-7
    纯度: >99.50%

    A LIMK and ROCK inhibitor

  • GC12425 structure
    GC12425CDK inhibitor II
    CAS: 1269815-17-9
    纯度: >98.50%

    CDK inhibitor II 是一种有效且特异性的 CDK9 抑制剂，IC50 <8 nM，取自参考文献 1，实施例 4。

  • GC12450 structure
    GC12450BI 2536
    CAS: 755038-02-9
    纯度: >99.50% / >98.00%

    BI 2536是一种双重Polo样激酶（PLK）/溴结构域抑制剂，在无细胞激酶实验中，BI 2536 对PLK1、PLK2和PLK3的半数抑制浓度（IC 50 ）值分别为0.83nM、3.5nM和9.0nM。

  • GC12604 structure
    GC12604Fumonisin B1
    CAS: 116355-83-0
    纯度: >98.00% / >95.00%

    A mycotoxin

  • GC12690 structure
    GC12690MLN8237 (Alisertib)
    CAS: 1028486-01-2
    纯度: >99.00%

    Alisertib (MLN8237) 作为一种在研、可口服的选择性极光 A 激酶抑制剂，通常用于治疗实体瘤和血液系统恶性肿瘤。

  • GC12752 structure
    GC12752RI-2
    CAS: 1417162-36-7
    纯度: >99.50%

    A RAD51 inhibitor

  • GC12788 structure
    GC12788Paprotrain
    CAS: 57046-73-8
    纯度: >99.50%

    A MKLP-2 inhibitor

  • GC12795 structure
    GC12795CCG-1423
    CAS: 285986-88-1
    纯度: >99.50%

    An inhibitor of Rho-mediated cell signalling

  • GC12817 structure
    GC12817K-115 hydrochloride dihydrate
    CAS: 887375-67-9
    纯度: >99.50%

    K-115 hydrochloride dihydrate (K-115) 是 ROCK 的特异性抑制剂，对 ROCK2 和 ROCK1 的 IC50 分别为 19 和 51 nM。

  • GC12826 structure
    GC12826AZD-5597
    CAS: 924641-59-8

    Potent CDK inhibitor

  • GC12865 structure
    GC12865BMS265246
    CAS: 582315-72-8
    纯度: >99.00%

    A cell-permeable inhibitor of Cdk1 and Cdk2