Cell Cycle/Checkpoint
Cell Cycle/Checkpoint(细胞周期/检查点)
Cell Cycle
Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more
- ATM/ATR(29)
- Aurora Kinase(58)
- Cdc42(4)
- Cdc7(3)
- Chk(14)
- c-Myc(27)
- CRM1(8)
- Cyclin-Dependent Kinases(77)
- E1 enzyme(1)
- G-quadruplex(12)
- Haspin(6)
- HMTase(1)
- Kinesin(27)
- Ksp(4)
- Microtubule/Tubulin(257)
- Mps1(15)
- Mitotic(7)
- RAD51(13)
- ROCK(74)
- Rho(13)
- PERK(11)
- PLK(43)
- PTEN(6)
- Wee1(9)
- PAK(25)
- Arp2/3 Complex(8)
- Dynamin(14)
- ECM & Adhesion Molecules(54)
- Cytoskeleton & Motor Proteins(65)
- Endomembrane System & Vesicular Trafficking(36)
- G1(51)
- Genotoxic Stress(23)
- G2/M(40)
- G2/S(17)
- Inositol Phosphates(67)
- Proteolysis(183)
- Cellular Chaperones(14)
- Cyclin G-associated Kinase (GAK)(1)
- MARK(3)
- NEKs(1)
Cell Cycle/Checkpoint 相关产品(1379)
- GC11401Roscovitine (Seliciclib,CYC202)CAS: 186692-46-6纯度: >98.50% / >98.00%
Roscovitine (Seliciclib,CYC202)是一种有效的Cdk2/cyclin E抑制剂，IC 50 值为0.1μM。Roscovitine还抑制Cdk7/cyclin H、Cdk5/p35以及（cdc）/cyclin B，IC 50 值分别为0.49、0.16和0.65μM。
- GC11823LY2835219 free baseCAS: 1231929-97-7纯度: >99.50% / >97.00% / >99.00%
LY2835219 free base是 CDK4 和 CDK6 的强效选择性抑制剂，在非细胞实验中的 IC 50 分别为 2nM 和 10nM。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC10537 | Triclabendazole | 68786-66-3 | >98.50% | |
A benzimidazole anthelmintic | ||||
| GC10546 | AZD7762 | 860352-01-8 | >99.50% | |
A selective checkpoint kinase inhibitor | ||||
| GC10557 | Dolastatin 10 trifluoroacetate | 2342568-65-2 | - | |
Antitumor agent | ||||
| GC10581 | ISRIB | 548470-11-7 | - | |
ISRIB是一种蛋白激酶R样内质网激酶（PERK）信号通路抑制剂，ISRIB能有效逆转真核翻译起始因子2亚基（eIF2α）磷酸化的效应，IC 50 值为5nM。 | ||||
| GC10681 | Eg5-I | 1338701-15-7 | - | |
A potent inhibitor of Eg5 | ||||
| GC10716 | Netarsudil (AR-13324) | 1253952-02-1 | - | |
ROCK抑制剂 | ||||
| GC10773 | TAK960 | 1137868-52-0 | >95.00% | |
A selective inhibitor of polo-like kinase 1 | ||||
| GC10793 | TCS 2312 | 838823-31-7 | - | |
checkpoint kinase 1 (chk1) inhibitor | ||||
| GC10870 | Cytochalasin J | 53760-20-6 | - | |
An inhibitor of actin polymerization | ||||
| GC10954 | Leptomycin B | 87081-35-4 | >99.50% | |
Leptomycin B (LMB)是染色体区域维持1 (CRM1)的抑制剂,CRM1是核蛋白输出蛋白之一。 | ||||
| GC11022 | SB 218078 | 135897-06-2 | >98.00% | |
A potent Chk1 inhibitor | ||||
| GC11181 | Thiazovivin | 1226056-71-8 | >99.00% / >98.00% | |
Thiazovivin是一种选择性Rho相关激酶（ROCK）抑制剂。 | ||||
| GC11252 | CW069 | 1594094-64-0 | >99.50% | |
An inhibitor of KIFC/HSET | ||||
| GC11292 | Mps1-IN-1 | 1125593-20-5 | >99.50% | |
A selective Mps1 kinase inhibitor | ||||
| GC11396 | SNS-032 (BMS-387032) | 345627-80-7 | >99.00% | |
A Cdk2, Cdk7, and Cdk9 inhibitor | ||||
| GC11401 | Roscovitine (Seliciclib,CYC202) | 186692-46-6 | >98.50% / >98.00% | |
Roscovitine (Seliciclib,CYC202)是一种有效的Cdk2/cyclin E抑制剂，IC 50 值为0.1μM。Roscovitine还抑制Cdk7/cyclin H、Cdk5/p35以及（cdc）/cyclin B，IC 50 值分别为0.49、0.16和0.65μM。 | ||||
| GC11410 | Aminopurvalanol A | 220792-57-4 | - | |
A selective CDK inhibitor | ||||
| GC11564 | Cdk4/6 Inhibitor IV | 359886-84-3 | - | |
A cell-permeable inhibitor of Cdk4/6 | ||||
| GC11593 | AZD0156 | 1821428-35-6 | >98.00% | |
An ATM kinase inhibitor | ||||
| GC11634 | NSC 693868 | 40254-90-8 | - | |
A selective inhibitor of Cdk1 and Cdk5 | ||||
| GC11754 | AS 1892802 | 928320-12-1 | - | |
A ROCK1 and ROCK2 inhibitor | ||||
| GC11785 | CDK4 inhibitor | 1256963-02-6 | - | |
An antiproliferative cyclin D1/Cdk4 inhibitor | ||||
| GC11823 | LY2835219 free base | 1231929-97-7 | >99.50% / >97.00% / >99.00% | |
LY2835219 free base是 CDK4 和 CDK6 的强效选择性抑制剂，在非细胞实验中的 IC 50 分别为 2nM 和 10nM。 | ||||
| GC11835 | Deferasirox | 201530-41-8 | >99.50% | |
Deferasirox是一种具口服活性的铁螯合剂，用于治疗铁过载疾病。 | ||||