Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC64938 AZD-7648 An inhibitor of DNA-PK
GC11593 AZD0156 An ATM kinase inhibitor
GC14709 AZD1152

5-[[7-[3-[乙基[2-(磷酰氧基)乙基]氨基]丙氧基]-4-喹唑啉基]氨基]-N-(3-氟苯基)-1H-吡唑-3-乙酰胺,AZD-1152;AZD 1152
AZD1152 (AZD1152) 是 AZD1152-hQPA 的前药，是一种高选择性的 Aurora B 抑制剂，在无细胞试验中 IC50 为 0.37 nM。 AZD1152 (AZD1152) 在癌细胞中诱导生长停滞和凋亡。
GC19468 AZD1390 AZD1390 是一种强效、高选择性、口服生物可利用的脑渗透性 ATM 抑制剂，在细胞中的 IC50 为 0.78 nM。
GC73016 AZD4877 AZD4877是Ispinesib的另一种同分异构体，也是一种激酶纺锤体蛋白（Eg5）抑制剂，IC50为2 nM。
GC16941 AZD6738

AZD6738
An ATR kinase inhibitor
GC10546 AZD7762

3-[(氨基羰基)氨基]-5-(3-氟苯基)-N-(3S)-3-哌啶基-2-噻吩羧胺
A selective checkpoint kinase inhibitor
GC62711 BAMEA-O16B BAMEA-O16B 是一种脂质纳米颗粒。BAMEA-O16B 结合了二硫键，可以有效地将 Cas9 mRNA 和 sgRNA 传递到细胞中，同时响应细胞内还原环境释放 RNA 进行基因组编辑。BAMEA-O16B 可用于基因编辑的研究。
GC14955 Barasertib (AZD1152-HQPA)

5-[[7-[3-[乙基(2-羟基乙基)氨基]丙氧基]-4-喹唑啉]氨基]-N-(3-氟苯基)-1H-吡唑-3-乙酰胺,AZD1152-HQPA,AZD-1152HQPA, AZD1152 HPQA,INH 34
A selective Aurora kinase B inhibitor
GC60620 Batabulin

巴他布林; T138067
An inhibitor of tubulin polymerization
GC60621 Batabulin sodium

T138067 sodium
An inhibitor of tubulin polymerization
GC42897 BAY 61-3606 (hydrochloride) A Syk inhibitor
GC33420 BAY-1895344

BAY 1895344
An ATR inhibitor
GC34374 BAY-1895344 hydrochloride An ATR inhibitor
GC19058 BAY1217389 An orally bioavailable inhibitor of Mps1
GC49757 Bazedoxifene N-oxide An oxidative degradation product of bazedoxifene
GC46907 Bazedoxifene-d4

1-[[4-[2-(六氢-1H-氮杂卓-1-基)乙氧基-1,1,2,2-D4]苯基]甲基]-2-(4-羟基苯基)-3-甲基-1H-吲哚-5-醇,TSE-424-d4
An internal standard for the quantification of bazedoxifene
GC60628 BD750 BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.5 μM and 1.1 μM for mouse and human T-cell proliferation, respectively.
GC32868 BDP5290 BDP5290对MRCKβ、ROCK1、ROCK2的IC50值分别为17nM、230nM、123nM和100nM，是ROCK和MRCK的有效抑制剂。
GC49042 Benastatin A A bacterial metabolite with diverse biological activities
GC49781 Benomyl

苯菌灵
A carbamate pesticide
GC49836 Benoxaprofen

氧苯恶唑丙酸,LRCL 3794
An NSAID
GC61831 Benproperine phosphate

磷酸苯丙哌林
An antitussive agent and ARPC2 inhibitor
GC49387 Berberine-d6 (chloride)

Natural Yellow 18-d6 chloride
An internal standard for the quantification of berberine
GC91234 Betaxolol-d7 (hydrochloride)
一种用于测定贝他索洛的内部标准。
GC12450 BI 2536

BI-2536;BI2536
BI 2536是一种双重Polo样激酶（PLK）/溴结构域抑制剂，在无细胞激酶实验中，BI 2536 对PLK1、PLK2和PLK3的半数抑制浓度（IC₅₀）值分别为0.83nM、3.5nM和9.0nM。
GC91898 BI SF3 (hydrochloride) BI SF3 (hydrochloride)是一种合成中间体。
GC17828 BI-847325 A selective dual MEK/Aurora kinase inhibitor
GC11224 BI6727(Volasertib)

伏拉塞替; BI 6727
A polo-like kinase inhibitor
GC42933 Binucleine 2 An inhibitor of Drosophila Aurora B kinase
GC49724 BIO-1211 (trifluoroacetate salt) A peptide inhibitor of α4β1 integrin
GC42936 Biotin Tripeptide-1

生物素酰基甘氨酰组氨酰赖氨酸
An ECM peptide conjugated to biotin
GC40155 Biotin-DEVD-CHO (trifluoroacetate salt)

Biotin-Asp-Glu-Val-Asp-CHO
A biotinylated caspase-3 and -7 inhibitor
GC42942 bis-ANS (potassium salt)

4,4'-二苯胺基-1,1'-联萘-5,5'-二磺酸二钾盐,4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic Acid

一种高亲和力非共价外源荧光染料
GC40060 Blasticidin A

灰瘟素A,(+)-Blasticidin A
A bacterial metabolite
GC11648 BML-277

Chk2 Inhibitor II
A selective DNA damage control kinase inhibitor
GC18408 BML-278

DIETHYL1-BENZYL-4-PHENYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE锛圵S201542锛,WUXIAPPTEC"
An activator of SIRT1, SIRT2, and SIRT3
GC12865 BMS265246 A cell-permeable inhibitor of Cdk1 and Cdk2
GC68021 BMVC BMVC 是一种有效的 G-四联体 (G4) 稳定剂和选择性的端粒酶 (Telomerase) 抑制剂，IC50 约为 0.2 μM。BMVC 抑制 Taq DNA 聚合酶，IC50 约为 2.5 μ M。BMVC 提高了端粒 G4 结构的熔化温度，并加速了端粒长度的缩短。抗癌活性。
GC63977 BMVC2

o-BMVC
BMVC2 (o-BMVC) 是 BMVC 的双取代咔唑衍生物，是一种 G 四联体 (G4) 稳定剂。
GC34102 BNC105 An inhibitor of tubulin polymerization
GC39483 BO-264 A TACC3 inhibitor
GC40149 Boc-AEVD-CHO (trifluoroacetate salt)

Boc-Ala-Glu-Val-Asp-CHO
An inhibitor of caspase-8
GC46937 Boc-Glu-OBzl

N-叔丁氧羰基-L-谷氨酸1-苄酯
An amino acid-containing building block
GC42959 BODIPY 493/503

4,4-二氟-1,3,5,7,8-五甲基-4-硼-3A,4A-二氮杂-S-茚烯,Pyrromethene 546; BDP 493/503 lipid stain

BODIPY 493/503是一种亲脂性荧光染料，发出明亮的绿色荧光，被广泛用于标记脂质滴（激发/发射：493/503纳米）。
GC42960 BODIPY 505/515

4,4-二氟-1,3,5,7-四甲基-4-硼-3A,4A-二氮杂-S-茚烯

BODIPY 505/515是一种亲脂性荧光染料，发出的荧光被广泛用于标记脂质滴（激发/发射：505/515纳米）。
GC42961 BODIPY 558/568 C12

Red C12
BODIPY 558/568 C12 是一种用于标记脂滴的脂肪酸偶联荧光探针。
GC14002 Bohemine A Cdk inhibitor
GC46942 Bortezomib-d15

LDP-341-d15, MG-341-d15, PS-341-d15
A neuropeptide with diverse biological activities
GC32846 BOS-172722 BOS172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 11 nM, Ki of 0.11 nM.