Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC48652 Olomoucine II

2-[[[2-[[(1R)-1-(羟基甲基)丙基]氨基]-9-(1-甲基乙基)-9H-嘌呤-6-基]氨基]甲基]苯酚
A CDK inhibitor
GC32551 Ombrabulin (AC-7700)

奥瑞布林,AVE8062; AC7700
Ombrabulin (AC-7700) (AVE8062) 是 CA-4 磷酸盐的衍生物，已知其通过选择性破坏内皮细胞的微管蛋白细胞骨架而表现出抗血管作用。
GC34022 Ombrabulin hydrochloride (AVE8062)

AVE8062 hydrochloride; AC7700 hydrochloride
A tubulin polymerization inhibitor and tumor vascular disrupting agent
GC62174 ON1231320 ON1231320 (7ao), an arylsulfonyl pyrido-pyrimidinone, is a highly specific inhibitor of polo like kinase 2 (PLK2). It also blocks tumor cell cycle progression in the G2/M phase in mitosis and causes apoptosis.
GC15607 ON123300

8-环戊基-7,8-二氢-2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-7-氧代-吡啶并[2,3-D]嘧啶-6-甲腈,ON123300
A multi-kinase inhibitor
GN10732 Oroxin B

木蝴蝶苷B
Oroxin B (OB) 是从中草药 Oroxylum indicum (L.) Vent 中分离得到的黄酮类化合物。Oroxin B (OB) 具有明显的抑制作用，通过上调 PTEN、下调 PTEN 诱导肝癌细胞早期凋亡而不是晚期凋亡COX-2、VEGF、PI3K 和 p-AKT.Oroxin B (OB) 在恶性淋巴瘤细胞中选择性诱导肿瘤抑制性 ER 应激。
GC64626 Oryzalin

氨磺乐灵
Oryzalin 是一种二硝基苯胺除草剂，能在体外与植物微管蛋白结合，抑制微管(MT)聚合。Oryzalin 可在有丝分裂周期的各个阶段解聚微管并阻止新微管的聚合。
GC33163 OSIP-486823 (OSIP 486823)

OSIP 486823; OSIP486823; CP248
OSIP-486823 (OSIP 486823) 是一种新型微管干扰剂，对蛋白激酶 G (PKG) 和微管具有独特的生物学效应。
GC50116 OXA 06 dihydrochloride Potent ROCK inhibitor
GC65897 OXi8007 OXi8007是一种 OXi8006（一种微管蛋白结合化合物）的水溶性磷酸盐前药。
GC45538 Oxychlororaphine

吩嗪-1-甲酰胺,phenazine-1-carboxamide
A microbial metabolite with diverse biological activities
GA23337 Oxythiamine . HCl

羟基硫胺盐酸盐
A thiamine antimetabolite
GC40256 p-APMSF (hydrochloride)

(4-脒苯基)甲磺酰氟盐酸盐
An irreversible inhibitor of serine proteases
GC91296 p-Carboxyphenyl Sulfate

Benzoic Acid-4-sulfate, 4-Carboxyphenyl Sulfate, para-Carboxyphenyl Sulfate, 4-Hydroxybenzoic Acid Sulfate, p-Hydroxybenzoic Acid Sulfate, para-Hydroxybenzoic Acid Sulfate

一种硫酸化的酚酸。
GC50599 P110 Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable
GC12511 Paclitaxel (Taxol)

紫杉醇
紫杉醇是从短叶红豆杉的树皮和针叶中提取出来的三环二萜化合物。
GC49404 Paclitaxel C

紫杉醇C
A taxoid and an inhibitor of microtubule depolymerization
GC45758 Paclitaxel octadecanedioate

1,18-Octadecanedioic Acid-Paclitaxel, ODDA-PTX, PTX-FA18
A prodrug form of paclitaxel
GC47853 Paclitaxel-d5

紫杉醇 d5
An internal standard for the quantification of paclitaxel
GC33421 PAK-IN-1 A group 2 PAK inhibitor
GC46196 Pal-KTTKS (acetate)

C16-KTTKS, Palmitoyl-KTTKS
A lipidated pentapeptide
GC15421 Palbociclib (PD0332991) Isethionate

帕博西尼羟乙基磺酸盐; PD 0332991 isethionate
Palbociclib (PD 0332991) isethionate 是一种具有口服活性的选择性 CDK4 和 CDK6 抑制剂，IC50 值分别为 11 和 16 nM。 Palbociclib (PD0332991) Isethionate 具有有效的抗增殖活性，可诱导癌细胞的细胞周期停滞，可用于 HR 阳性和 HER2 阴性乳腺癌和肝细胞癌的研究。
GC47858 Palmitelaidic Acid-d13

棕榈酸酯 d13
A neuropeptide with diverse biological activities
GC49024 Palmitic Acid MaxSpec® Standard

棕榈酸
A long-chain saturated fatty acid
GC49023 Palmitic Acid-d9 MaxSpec® Standard

棕榈酸-13,13,14,14,15,15,16,16,16-D9
A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications
GC49014 Palmitoyl Tetrapeptide-7 (acetate)

N-Palmitoylrigin, Pal-Gly-Gln-Pro-Arg-OH
A cosmeceutical peptide
GC15940 PalMitoyl Tripeptide-1

棕榈酰三肽-1
A form of GHK containing palmitic acid
GC49702 Papain Inhibitor (trifluoroacetate salt)

GGYR, Gly-Gly-Tyr-Arg
A peptide inhibitor of papain
GC12788 Paprotrain

(ALPHAZ)-ALPHA-(3-吡啶基亚甲基)-1H-吲哚-3-乙腈
A MKLP-2 inhibitor
GC45541 PAR3 (1-6) amide (human) (trifluoroacetate salt)

Proteinase-Activated Receptor 3, TFRGAP-NH2
A peptide agonist of PAR1 and PAR2
GC45944 para-amino-Blebbistatin

(-)-4'-amino-Blebbistatin, p-amino-Blebbistatin, (S)-4'-amino-Blebbistatin
A more stable and less phototoxic form of (–)-blebbistatin with enhanced water solubility
GC47923 Paraxanthine-d6

1,7-Dimethylxanthine-d6
An internal standard for the quantification of paraxanthine
GC32134 Parbendazole (SKF 29044)

帕苯咪唑,SKF 29044
An inhibitor of microtubule assembly
GC40085 Pazopanib-d6

培唑帕尼-d6,GW786034-d6
An internal standard for the quantification of pazopanib
GC33002 PBOX 6 PBOX6是一种pyrrolo-1,5-benzoxazepine(PBOX)化合物，可作为微管解聚剂和促凋亡剂起作用。
GC73755 PC5-VC-PAB-MMAE PC5-VC-PAB-MMAE由adc连接剂（PC5-VC-PAB）和强效微管蛋白抑制剂（MMAE）组成。
GC15173 PD 0332991 (Palbociclib)

帕布昔利布（palbociclib）,PD0332991;PD-0332991;PD 0332991
PD 0332991 (Palbociclib) (PD 0332991) 是一种具有口服活性的选择性 CDK4 和 CDK6 抑制剂，IC50 值分别为 11 和 16 nM。 PD 0332991 (Palbociclib) 具有有效的抗增殖活性，可诱导癌细胞的细胞周期停滞，可用于 HR 阳性和 HER2 阴性乳腺癌和肝细胞癌的研究。
GC17935 PD 0332991 (Palbociclib) HCl

帕布昔利布盐酸盐,PD0332991;PD-0332991;PD 0332991
PD 0332991 作为 CDK4 和 CDK6 激酶的口服活性强效和高选择性抑制剂，可以在低纳摩尔浓度下阻断 pRb 磷酸化并随后在敏感细胞系中诱导 G1 期停滞。
GC50045 PD 166285 dihydrochloride

6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮盐酸盐
A tyrosine kinase inhibitor
GC44584 PD 168368 An antagonist of NMB receptors
GC32853 PD0166285

6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮
PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations (IC50=24 nM for Wee1 and 72 nM for Myt1). PD0166285 is also a novel G2 checkpoint abrogator. PD0166285 induces apoptosis.
GC72924 PD173952 PD173952是一种酪氨酸激酶抑制剂，对Lyn、Abl和Csk的ic50分别为0.3、1.7和6.6 nM。
GC91688 PDIC-NN PDIC-NN is an intermediate in the synthesis of PDIC-NS , an activator of stimulator of interferon genes (STING) with anticancer activity.
GC91820 PDIC-NS PDIC-NS is an activator of stimulator of interferon genes (STING).
GC30801 PE859 PE859是tau和Aβ积累的有效抑制剂，IC50值分别为0.66和1.2μM。
GC40622 Penicillide

Vermixocin A
A fungal metabolite with diverse biological activities
GC33901 Pentanoic acid Pentanoicacid是一种短链脂肪酸，是细菌代谢产物，与过敏性皮肤病有关系。Pentanoicacid能够激活ROCK信号通路。
GC50439 Peptide5 Peptide5 是一种连接蛋白 43 模拟肽，可减少脊髓损伤后动物肿胀、星形胶质细胞增生和神经元细胞死亡体外:Peptide5 显着降低啮齿动物离体模型中的脊髓损伤 (SCI) 程度。
GC90582 Perfluorooctanesulfonic Acid

Heptadecafluorooctanesulfonic Acid, Perfluorooctane sulfonate, Perfluorooctylsulfonic Acid, PFOS

一种全氟烷基物质
GC69687 PERK-IN-2 PERK-IN-2 是一种高效的 PERK 抑制剂，其 IC50 值为 0.2 nM。